Abstract
Cryoablation, initially described for breast tumors in the 1980s, has generated significant interest as a promising method of nonoperative therapy for breast cancer. The procedure is ideally suited to be performed in the office setting under local anesthesia using real-time ultrasound guidance. In addition to the promise of nonoperative therapy for early-stage breast cancer, cryoablation has been shown in some situations to generate an antitumor immune response. Ongoing studies are evaluating the effectiveness of cryoablation for breast cancer as well as answering questions regarding patient selection and immune response. While most published and ongoing studies have involved surgical resection after ablation, this technology is extremely promising as a replacement to surgical therapy for selected patients with early-stage breast cancer.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Whitworth PW, Rewcastle JC. Cryoablation and cryolocalization in the management of breast disease. J Surg Oncol. 2005;90:1–9.
Sabel MS, Su G, Griffith KA, Chang AE. Rate of freeze alters the immunologic response after cryoablation of breast cancer. J Surg Oncol. 2005;17:1187–93.
Huston TL, Simmons RM. Ablative therapies for the treatment of malignant diseases of the breast. Am J Surg. 2005;189:694–701.
Sabel MS, Kaufman CS, Whitworth P, Chang H, Stocks LH, Simmons R, Schultz M. Cryoablation of early-stage breast cancer: work-in-progress report of a multi-institutional trial. Ann Surg Oncol. 2004;11(5):542–9.
Littrup PJ, Jallad B, Chandiwala-Mody P, D’Agostini M, Adam BA, Bouwman D. Cryotherapy for breast cancer: a feasibility study without excision. J Vasc Interv Radiol. 2009;20:1329–41.
Tatli S, Acar M, Tuncali K, Morrison PR, Silverman S. Percutaneous cryoablation techniques and clinical applications. Diagn Interv Radiol. 2010;16:90–5.
Giuliano AE, Hunt KK, Ballman KV, Beitsch PD, Whitworth PW, Blumencranz PW, Leitch AM, Saha S, McCall LM, Morrow M. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis—a randomized clinical trial. JAMA. 2011;305(6):569–75.
Kaufman CS, Rewcastle JC. Cryosurgery for breast cancer. Technol Cancer Res Treat. 2004;3(2):165–75.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Attai, D. (2014). Cryoablation for Breast Cancer. In: Francescatti, D., Silverstein, M. (eds) Breast Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8063-1_11
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8063-1_11
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-8062-4
Online ISBN: 978-1-4614-8063-1
eBook Packages: MedicineMedicine (R0)