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Analysis of Heart Rate Variability

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Complex Systems and Computational Biology Approaches to Acute Inflammation

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Abstract

Analysis of heart rate variability—the magnitude and subtle patterns of variation in length of the cardiac cycle from one heartbeat to the next—continues to yield new insights into the role of regulatory mechanisms in acute inflammation and other pathophysiology of critical illness. However, diverse methods of calculating heart rate variability and a large body of literature spanning many application domains can make selection of a particular technique and interpretation of results difficult for newcomers to the field. This chapter serves as a brief introduction for those beginning to undertake heart rate variability analyses, with emphasis on applications to the study of inflammation and critical care. It covers the biological basis and rationale for measuring heart rate variability in these domains and introduces several popular analytic methods and freely available tools for implementing these techniques. Finally, ongoing research efforts are briefly reviewed that may lead to novel diagnostic and therapeutic opportunities for improving the management of acute inflammation and other aspects of critically ill patient care.

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Authors and Affiliations

  1. Departments of Informatics Administration and Surgery, Vanderbilt University Medical Center, 3401 West End Ave., Suite 500, Nashville, TN, 37203, USA

    Patrick R. Norris Ph.D.

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  1. Patrick R. Norris Ph.D.
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Correspondence to Patrick R. Norris Ph.D. .

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  1. University of Pittsburgh Inflammation and Regenerative Modeling, Pittsburgh, Pennsylvania, USA

    Yoram Vodovotz

  2. University of Chicago Medical Center MC 5094, Chicago, Illinois, USA

    Gary An

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Norris, P.R. (2013). Analysis of Heart Rate Variability. In: Vodovotz, Y., An, G. (eds) Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8008-2_4

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