Polymer- and Lipid-Based Systems for Parenteral Drug Delivery
The field of drug delivery technology research has continued to grow in recent decades, expanding from technologies traditionally focused on controlled release to now include nanotechnologies and functionalized molecular architectures for target-specific delivery. While these emerging novel technologies are beginning to mature, many of the clinical applications of controlled-release drug delivery technologies continue to focus on well-characterized biodegradable polymer particles, in situ forming gel depots, and lipid-based particulate formulations. This review principally focuses on the physicochemical and functional characteristics of in situ forming semisolid depot formulations and lipid-based drug delivery technologies and also discusses the broader considerations in bringing drug delivery-enabled products to market.
KeywordsCholesterol Surfactant Glycol Syringe Sarcoma
- Dunn RL (2002) The atrigel drug delivery system. In: Rathbone MJ, Hadgraft J, Roberts MS (eds) Modified Release Drug Delivery Technology. Marcel Dekker, New York, pp 647–656Google Scholar
- Dunn DL, English JP, Cowsar DR, Vanderbelt DP (1990) Biodegradable in situ forming implants and methods of producing the same. US Patent 4,938,763Google Scholar
- ElBayoumi TA, Torchilin VP (2009) Current trends in liposome research. In: Weissig V (ed) Liposomes, methods and protocols. Springer, New York, pp 1–27Google Scholar
- Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH Jr, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA (2005) A comprehensive classification system for lipids. J Lipid Res 46(5):839–861PubMedCrossRefGoogle Scholar
- Janoff AS (1999) Liposomes as pharmaceuticals. In: Jannoff AS (ed) Liposomes: rational design. Marcel Dekker, New York, pp xix–xxxiGoogle Scholar