Monocytic sarcoma is an extramedullary tumor mass composed of monocytic or myelomonocytic blasts with or without maturation. Many clinical features of patients with monocytic sarcoma mirror those of patients with granulocytic sarcoma (the reader is referred to the previous chapter). Most patients affected with monocytic sarcoma are adults, and the median age is in the sixth decade of life.
Monocytic sarcomas have a pronounced tendency to involve skin. Other frequently affected sites are lymph node, gastrointestinal tract, and soft tissue. Most cases of monocytic sarcoma occur in patients with acute myeloid leukemia (AML) falling in the French–American–British (FAB) categories M4 or M5, but there are reports of monocytic sarcoma associated with several categories of AML in the current World Health Organization (WHO) classification.
KeywordsAcute Myeloid Leukemia Plasmacytoid Dendritic Cell Granulocytic Sarcoma Immunophenotypic Analysis Blastic Plasmacytoid Dendritic Cell Neoplasm
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