Follicular Lymphoma

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


Follicular lymphoma (FL) is a neoplasm of germinal center B-cells that usually displays a follicular growth pattern. FL is one of the most common lymphomas in the Western hemisphere. Patients are usually elderly and present with generalized lymphadenopathy, frequent extranodal disease, and bone marrow involvement. The clinical course is usually indolent.

Lymph nodes usually show complete effacement of the architecture by neoplastic follicles that frequently extend through the capsule and perinodal soft tissues. In cases that partially involve lymph node, reactive follicles, open sinuses, and plasmacytosis may be observed.


Follicular Lymphoma Germinal Center Bone Marrow Involvement Mantle Zone Open Sinus 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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