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Macrophages and Microglia in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

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Multiple Sclerosis Immunology

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Abstract

Multiple Sclerosis (MS) is a complex inflammatory and demyelinating disease of the central nervous system (CNS) that is a leading cause of disability in young Caucasian adults. The pathogenesis of MS involves adaptive immune components such as T and B cells and innate immune cells including monocytes, macrophages, and microglia. Indeed, the predominant groups of inflammatory cells in active plaques are macrophages and microglia, and these persist through secondary progressive MS. In this chapter, we focus on the roles of macrophages and microglia in MS and its animal model experimental autoimmune encephalomyelitis (EAE).

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Authors and Affiliations

  1. Hotchkiss Brain Institute, University of Calgary, Hospital Drive, 3330, T2N 4N1, Calgary, AB, Canada

    Manoj Kumar Mishra & V. Wee Yong PhD

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  1. Manoj Kumar Mishra
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  2. V. Wee Yong PhD
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Correspondence to V. Wee Yong PhD .

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  1. National Institute of Neuroscience, National Center of Neurology and Psychia, Tokyo, Japan

    Takashi Yamamura

  2. Clinical Neurology, University of Nottingham, Nottingham, United Kingdom

    Bruno Gran

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Mishra, M., Yong, V. (2013). Macrophages and Microglia in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. In: Yamamura, T., Gran, B. (eds) Multiple Sclerosis Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7953-6_9

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