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Multiple Sclerosis Immunology pp 27–47Cite as

Regulatory T Cells in MS

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Abstract

Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system (CNS), caused by an autoimmune response to self-antigens in a genetically susceptible individual. It is characterized by progressive neurodegeneration and by CNS lesions containing a high number of infiltrating autoreactive B and T cells. In healthy individuals, regulatory T (Treg) cells can control potentially pathogenic autoreactive T cells, while Treg cells in MS patients show insufficient regulatory abilities. The fact that autoreactive T cells can be found in the peripheral blood of healthy individuals without causing any autoimmune diseases underlies the importance of an efficient control of immune responses. Treg cells are key regulators of immune homeostasis and self-tolerance.

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Authors and Affiliations

  1. Departments of Neurology and Immunobiology, Yale School of Medicine, 06520, New Haven, CT, USA

    Barbara B. Gawlik & David A. Hafler

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  1. Barbara B. Gawlik
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  2. David A. Hafler
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Correspondence to Barbara B. Gawlik .

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  1. National Institute of Neuroscience, National Center of Neurology and Psychia, Tokyo, Japan

    Takashi Yamamura

  2. Clinical Neurology, University of Nottingham, Nottingham, United Kingdom

    Bruno Gran

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Gawlik, B., Hafler, D. (2013). Regulatory T Cells in MS. In: Yamamura, T., Gran, B. (eds) Multiple Sclerosis Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7953-6_2

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