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A Novel Concept of Treatment in MS: Targeting Both Oligodendrocyte Death and Inflammatory Processes by Inhibiting Poly(Adp-Ribose) Polymerase

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Multiple Sclerosis Immunology

Abstract

The pathology of multiple sclerosis (MS) was originally defined by inflammation, focal primary demyelination in the white matter, and astrocytic gliosis. This plaque-centered view of MS pathology has been revised during the last years (Lassmann et al. Brain Pathol 17:210–218, 2007). It became clear that pathology is not restricted to focal white matter lesions, but that demyelination may also affect the gray matter, most prominently the cerebral and cerebellar cortex (Peterson et al. Ann Neurol 50:389–400, 2001; Kutzelnigg et al. Brain 128:2705–2712, 2005)

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Acknowledgments

This work was supported by TAMOP 4.2.1B-10/2KONV and 4.2.2B-10/1 as well as by 34039/KA-OTKA/11–06, OTKA K77892.

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Authors and Affiliations

  1. Department of Neurology and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

    Zsolt Illes

  2. Department of Neurology, University of Pecs Medical School, Pecs, Hungary

    Zsolt Illes

  3. Center for Brain Research, Medical University of Vienna, Vienna, Austria

    Hans Lassmann

  4. Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, Hungary

    Ferenc Gallyas Jr

  5. Nuclear-Mitochondrial Interactions Research Group, Hungarian Academy of Sciences, Budapest, Hungary

    Ferenc Gallyas Jr

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  1. Zsolt Illes
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  2. Hans Lassmann
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  3. Ferenc Gallyas Jr
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Correspondence to Zsolt Illes .

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Editors and Affiliations

  1. National Institute of Neuroscience, National Center of Neurology and Psychia, Tokyo, Japan

    Takashi Yamamura

  2. Clinical Neurology, University of Nottingham, Nottingham, United Kingdom

    Bruno Gran

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Illes, Z., Lassmann, H., Gallyas, F. (2013). A Novel Concept of Treatment in MS: Targeting Both Oligodendrocyte Death and Inflammatory Processes by Inhibiting Poly(Adp-Ribose) Polymerase. In: Yamamura, T., Gran, B. (eds) Multiple Sclerosis Immunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7953-6_15

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