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Histone Chaperones, Epigenetics, and Cancer

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Book cover Systems Analysis of Chromatin-Related Protein Complexes in Cancer

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Abstract

Histone chaperones such as CAF1, ASF1, HIRA, DEK, DAXX, and several others play central roles in the transport, modification, replication, and replacement of nucleosomes. These diverse roles affect many processes including epigenetic memory, genome stability, transcription, Polycomb function, and others. Here, we review these functions and their relevance to heterochromatin, epigenetic inheritance, and cancer.

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Author information

Authors and Affiliations

  1. Laboratory of Medicine and Pathobiology, Genetics and Development Division, University of Toronto, Toronto, ON, Canada

    Mina Rafiei Ph.D.

  2. Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, Toronto, ON, Canada

    Rod Bremner Ph.D.

  3. Toronto Western Research Institute, Mc6-424, 399 Bathurst St., Toronto, ON, Canada, M5T2S8

    Rod Bremner Ph.D.

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  1. Mina Rafiei Ph.D.
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  2. Rod Bremner Ph.D.
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Correspondence to Rod Bremner Ph.D. .

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  1. Banting & Best Dept. Medical Research, University of Toronto Donnelly Ctr Cell. & Biomolecular Res., Toronto, Ontario, Canada

    Andrew Emili

  2. University of Toronto Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada

    Jack Greenblatt

  3. Molecular Structure and Function Program, The Hospital for Sick Children, Toronto, Ontario, Canada

    Shoshana Wodak

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Rafiei, M., Bremner, R. (2014). Histone Chaperones, Epigenetics, and Cancer. In: Emili, A., Greenblatt, J., Wodak, S. (eds) Systems Analysis of Chromatin-Related Protein Complexes in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7931-4_15

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