Abstract
As noted in the introduction, the Oxford chemist and Nobel Laureate Sir Cyril Hinshelwood defined science as “… an imaginative adventure of the mind seeking truth in a world of mystery” (Hinshelwood 1954, p. 301). In the lines quoted above he cautioned that the quest is not without its challenges. Science constitutes an endless quest of nature for knowledge and wisdom. Unique among fields of mental enterprise, it requires curiosity, creativity, and dedicated work, and is characterized by communalism, universalism, disinterestedness, originality, and skepticism. Science possesses an informal quality-assurance system of peer-review, publication, and independent replication. As noted earlier, this essay might be viewed as a case study in the manner in which a special field of biomedical science has emerged and continues to evolve, and the way in which individuals, their ideas, and social forces critically interact in that development. As with much of contemporary biomedical science, fetal and neonatal physiology is based in general on the “Galilean-Harveian” hypothetico-deductive method, with the careful analysis of observed phenomena, generation of a testable hypothesis, designing and recording of experiments to test these hypotheses, and the further wholesale collection of observations and data to explore a more refined hypothesis. These are generated in sufficient detail to extend beyond mere empirical observation, and allow the innovation of quantitative reasoning to establish a proposed general principle and to enable reproducibility.
If we are to vindicate the claim to be seeking the nature of things, then it must be extensive. The broad picture must be sought, outworn detail discarded, and all help possible derived from simplifications and generalizations … This is no doubt more easily said than done, but whoever believed that our task is an easy one? Nor is our responsibility lessened by the need … of guarding against the superficial and the inaccurate, of deriving full benefit from the intensive approach and from special disciplines, and of combining the survey of the small-scale map with the detailed scrutiny of the large-scale insets.
(Sir Cyril Hinshelwood 1954, p. 307)
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
I Corinthians 13:12, King James Version.
References
Atkinson JW (1985) Models and myths of science: views of the elephant. Am Zool 25:727–736
Bacon F (1620a) Novum organum scientiarum. Apud Joannem Billium, Typographum Regium, Londini
Bacon F (1620b) Francisci de Verulamio Instauratio magna multi pertransibunt & augebitur scientia. Londini, Apud Joannem Billium, Typographum Regium
Bacon F (1623) Francisci Baronis de Verulamio, Vice-Comitis Sancti Albani, De dignitate & augmentis scientiarum libri IX. In officina Ioannis Hauiland, Londini
Bayes T (1763) An essay towards solving a problem in the doctrine of chances. Philos Trans 53:370–418
Bayes T (1958) An essay towards solving a problem in the doctrine of chances. Biometrika 45:296–315
Bernard C (1865) Introduction à l’etude de la médecine experémentale. Baillière, Paris
Brecht B (1938–1939) Leben des Galilei: schauspiel. Suhrkamp Verlag, Berlin
Cadman EC (1994) The academic physician-investigator: a crisis not to be ignored. Ann Intern Med 120:401–410
Calder R (1951) Profile of science. George Allen & Unwin, London
Carson R (1962) Silent spring. Fawcett, Greenwich, CT
Chamberlin TC (1965) The method of multiple working hypotheses: with this method the dangers of parental affection for a favorite theory can be circumvented. Science 148:754–759
Comroe JH Jr (1977) Retrospectroscope. Speculation on speculation. Am Rev Respir Dis 115:343–349
Comroe JH Jr, Dripps RD (1974) Ben Franklin and open heart surgery. Circ Res 35:661–669
Comroe JH Jr, Dripps RD (1976) Scientific basis for the support of biomedical science. Science 192:105–111
Davis RH (2006) Strong inference: rationale or inspiration? Perspect Biol Med 49:238–249
Dawes GS (1985) Perinatal physiology, the past, present and future. In: Jones CT, Nathanielsz PW (eds) The physiological development of the fetus and newborn. Academic, London, pp 827–830
Eliot TS (1963) The Rock. In: Collected poems 1909–1962. Harcourt Brace & World, Inc., New York, NY
Feinstein AR (1977) Clinical biostatistics. XXXIX. The haze of Bayes, the aerial palaces of decision analysis, and the computerized Ouija board. Clin Pharmacol Ther 21:482–496
Franklin KJ (1953) Joseph Barcroft 1872–1947. Oxford University Press, Oxford
Goldstein JL, Brown MS (1997) The clinical investigator: bewitched, bothered, and bewildered – but still beloved. J Clin Invest 99:2803–2812
Hiebert SM (2007) The strong-inference protocol: not just for grant proposals. Adv Physiol Educ 31:93–96
Hinshelwood SC (1954) Thoughts on the evolution of a scientific problem. Sch Sci Rev 35:300–308
Hinshelwood SC (1960) Address of the President …, at the Formal Opening Ceremony of the Tercentenary Celebrations at the Royal Albert Hall, 19 July 1960. Proc R Soc Lond A 257:421–430
Howson C, Urbach P (2005) Scientific reasoning: the Bayesian approach. Open Court Publishing, Chicago, IL
Jensen FV (1996) An introduction to Bayesian networks. Springer, New York, NY
Kinraide TB, Denison RF (2003) Strong inference: the way of science. Am Biol Teacher 65:419–424
Krebs HA (1967) The making of a scientist. Nature 215:1441–1445
Kretchmer N (1968) On the homology between human development and pediatrics. Pediatr Res 2:283–286
Kretchmer N (1977) Prospectives in pediatric research. Pediatr Res 11:992–993
Kretchmer N, Hasselmeyer EG (1974) Horizons in perinatal research. Implications for clinical care. Wiley, New York, NY
Kuhn TS (1962) The structure of scientific revolutions. University of Chicago Press, Chicago, IL
Kuhn TS (2012) The structure of scientific revolutions, 4th edn. University of Chicago Press, Chicago, IL
Lipton P (2005) Testing hypotheses: prediction and prejudice. Science 307:219–221
Longo LD, Jaffe RB (2008) A challenge for the twenty-first century: whither physician scientists in obstetrics and gynecology and the reproductive sciences? Am J Obstet Gynecol 198:489–495
Longo LD, McClure ME, Jaffe RB (1999) Reproductive physician–scientists for the twenty-first century. Am J Obstet Gynecol 181:934–939
Macklem PT (2008) Emergent phenomena and the secrets of life. J Appl Physiol 104:1844–1846
Mandelbrot BB (1977) Fractals: form, chance, and dimension. W.H. Freeman, San Francisco, CA
Mandelbrot BB (1982) The fractal geometry of nature. W.H. Freeman, San Francisco, CA
Medawar PB (1969) Induction and intuition in scientific thought. Jayne lectures for 1968. American Philosophical Society, Philadelphia, PA
Merton RK (1965) On the shoulders of giants. A Shandean postscript. With a foreword by C.D. Bowen. The Free Press, New York, NY
Nabel GJ (2009) The coordinates of truth. Science 326:53–54
Neilson EG, Ausiello D, Demer LL (1995) Physician–scientists as missing persons. J Investig Med 43:534–542
Perutz MF (1976) Fundamental research in molecular biology: relevance to medicine. Nature 262:449–453
Platt JR (1964) Strong inference. Certain systematic methods of scientific thinking may produce much more rapid progress than others. Science 146:347–353
Poincaré H (2000) Reflections. Mathematical creation. Resonance 5:85–94
Polanyi M (1946) Science, faith and society. Oxford University Press, London
Polanyi M (1958) Personal knowledge: towards a post-critical philosophy. University of Chicago Press, Chicago, IL
Polanyi M (1966) The tacit dimension. Doubleday, Garden City, NY
Popper KR (1959) The logic of scientific discovery. Basic Books, Inc., New York, NY
Popper KR (1999) All life is problem solving. Routledge, London
Reynolds SRM (1978) Many slender threads: an essay on progress in perinatal research. In: Longo LD, Reneau DD (eds) Fetal and newborn cardiovascular physiology, vol 1. Garland STPM Press, New York, NY, pp 33–45
Rorschach H (1921) Psychodiagnostik; Methodik und Ergebnisse eines wahrnehmungsdiagnostischen Experiments; Deutenlassen von Zufallsformen. Bircher, Bern
Rosenberg L (1999) Physician–scientists – endangered and essential. Science 283:331–332
Schechter AN (1998) The crisis in clinical research: endangering the half-century National Institutes of Health Consensus. JAMA 280:1440–1442
Szent-Györgyi A (1971) Looking back. Perspect Biol Med 15:1–5
Szent-Györgyi A (1974) Research grants. Perspect Biol Med 18:41–43
Theocharis T, Psimopoulos M (1987) Where science has gone wrong. Nature 329:595–598
Thomas L (1977) On the science and technology of medicine. Daedalus 106:35–46, Reprinted 117:299–316, 1988
Thornton S (2011) Karl Popper. In: The Stanford encyclopedia of philosophy (Winter 2011 Edition). Zalta EN (ed). (http://plato.stanford.edu/archives/win2011/entries/popper/)
Walton I (1983) The compleat angler, 1653–1676. J. Bevan (ed). Clarendon, Oxford
Weimer WB (1979) Notes on the methodology of scientific research. Lawrence Erlbaum Associates, Publishers, Hillsdale, NJ
Wenner AM (1989) Concept-centered versus organism-centered biology. Am Zool 29:1177–1197
Weyl H (1944) David Hilbert 1862–1943. Obit Not Fell R Soc 4:547–553
Whewell W (1837) History of the inductive sciences: from the earliest to the present times. John W. Parker, London
Wyngaarden JB (1979) The clinical investigator as an endangered species. N Engl J Med 301:1254–1259
Wyngaarden JB (1983) Directions and challenges in health sciences research. Environ Health Perspect 52:271–275
Wyngaarden JB (1984) Nurturing the scientific enterprise. J Med Educ 59:155–161
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 American Physiological Society
About this chapter
Cite this chapter
Longo, L.D. (2013). Epilogue. In: The Rise of Fetal and Neonatal Physiology. Perspectives in Physiology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7921-5_22
Download citation
DOI: https://doi.org/10.1007/978-1-4614-7921-5_22
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-7920-8
Online ISBN: 978-1-4614-7921-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)