Some Aspects of the Developing Brain and Nervous System

  • Lawrence D. Longo
Chapter
Part of the Perspectives in Physiology book series (PHYSIOL, volume 1)

Abstract

As knowledge of human development increases, the sobering reality is becoming evident that the foundations for much of our life as adults, including our state of mind and life, are established in our mother’s womb prior to birth. Growth and development of the brain, the most complex organ not only in the body, but probably in the universe, is unique in many respects. As with other cells, those of the nervous system have identical genomic DNA sequences (the template of our heredity and instruction sets for gene expression); however, they develop into strikingly different and unique phenotypes. Neurons, the cells responsible for signaling, conducting, and communication, convert a variety of stimuli into control of short- and long-term memory, consciousness, and behavior. By late-gestation in the developing fetus, following a “brain growth spurt” neuron number is established with only modest postnatal neurogenesis other than in the dentate gyrus of the hippocampus and the periventricular and subventricular zones (PVZ and SVZ). Supporting astrocytes and glial cells follow a similar course, with a delay of several weeks. Maturation of oligodendrocytes with formation of myelin follows a much later time course. In view of the complexity of orchestrated neurogenesis with axon and dendrite formation during this period of rapid growth, specialized cell type differentiation with their neurotransmitters, migration, the connectivity of literally billions of synapses, and selective cell death, the brain is exquisitely sensitive to factors that may alter and interfere with its normal pattern of growth and development (Fig. 12.1).

Keywords

Migration Ischemia Manifold Retina Germinal 

References

  1. Aarnoudse-Moens CS, Weisglas-Kuperus N, van Goudoever JB, Oosterlaan J (2009) Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics 124:717–728PubMedCrossRefGoogle Scholar
  2. Aguirre A, Rubio ME, Gallo V (2010) Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature 467:323–327PubMedCrossRefGoogle Scholar
  3. Altman J (1962) Are new neurons formed in the brains of adult mammals? Science 135:1127–1128PubMedCrossRefGoogle Scholar
  4. Altman J, Das GD (1965) Post-natal origin of microneurons in the rat brain. Nature 207:953–956PubMedCrossRefGoogle Scholar
  5. Altman J, Das GD, Sudarshan K (1970) The influence of nutrition on neural and behavioral development. I. Critical review of some data on the growth of the body and the brain following dietary deprivation during gestation and lactation. Dev Psychobiol 3:281–301PubMedCrossRefGoogle Scholar
  6. Aresin L (1962) Beitrag zur embryonalen Elektroenzephalographie. Confinia neurol 22:121–127CrossRefGoogle Scholar
  7. Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ (2010) Early life programming and neurodevelopmental disorders. Biol Psychiatry 68:314–319PubMedCrossRefGoogle Scholar
  8. Bartelmez GW (1973) Charles Judson Herrick 1868–1960. Biogr Mem Natl Acad Sci 43:77–108PubMedGoogle Scholar
  9. Bayer SA (1989) Cellular aspects of brain development. Neurotoxicology 10:307–320PubMedGoogle Scholar
  10. Bevan JA, Bevan RD (1981) Developmental influences on vascular structure and function. Ciba Found Symp 83:94–107PubMedGoogle Scholar
  11. Bevan RD, Bevan JA (1994) The human brain circulation: functional changes in disease. Humana, Totowa, NJCrossRefGoogle Scholar
  12. Bevan JA, Su C (1973) Sympathetic mechanisms in blood vessels: nerve and muscle relationships. Annu Rev Pharmacol 13:269–285PubMedCrossRefGoogle Scholar
  13. Bevan JA, Bevan RD, Duckles SP (1980) Adrenergic regulation of vascular smooth muscle, Handbook of physiology. The cardiovascular system. Vascular smooth muscle. American Physiological Society, Bethesda, MD, pp 515–566Google Scholar
  14. Blood AB, Zhao Y, Long W, Zhang L, Longo LD (2002) L-type Ca2+ channels in fetal and adult ovine cerebral arteries. Am J Physiol Regul Integr Comp Physiol 282:R131–R138PubMedGoogle Scholar
  15. Borrelli E, Nestler EJ, Allis CD, Sassone-Corsi P (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60:961–974PubMedCrossRefGoogle Scholar
  16. Bota M, Dong HW, Swanson LW (2003) From gene networks to brain networks. Nat Neurosci 6:795–799PubMedCrossRefGoogle Scholar
  17. Busija DW, Heistad DD (1984) Factors involved in the physiological regulation of the cerebral circulation. Rev Physiol Biochem Pharmacol 101:161–211PubMedCrossRefGoogle Scholar
  18. Coghill GE (1929) Anatomy and the problem of behavior. Cambridge University Press, CambridgeGoogle Scholar
  19. Coghill GE (1933) The neuro-embryonic study of behavior: principles, perspective and aim. Science 78:131–138PubMedCrossRefGoogle Scholar
  20. Cohen S, Greenberg ME (2008) Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. Annu Rev Cell Dev Biol 24:183–209PubMedCrossRefGoogle Scholar
  21. Davies K (2001) Nature vs. nurture revisited. http://www.pbs.org/wgbh/nova/body/nature-versus-nurture-revisited.html. Accessed 15 Nov 2012
  22. Davison AN, Dobbing J (1966) Myelination as a vulnerable period in brain development. Br Med Bull 22:40–44PubMedGoogle Scholar
  23. Del Toro J, Louis P, Goddard FJ, Finegold J (1991) Cerebrovascular regulation and neonatal brain injury. Pediatr Neurol 7:3–12PubMedCrossRefGoogle Scholar
  24. Dobbing J (1968) Vulnerable periods in developing brain. In: Davison AN, Dobbing J (eds) Applied neurochemistry. F.A. Davis Company, Philadelphia, PA, pp 287–316Google Scholar
  25. Dobbing J (1974) The later development of the brain and its vulnerability. In: Davis JA, Dobbing J (eds) Scientific foundations of paediatrics. William Heinemann Medical Books Ltd., London, pp 565–577Google Scholar
  26. Dobbing J (1981) Maternal nutrition in pregnancy-eating for two? Early Hum Dev 5:113–115PubMedCrossRefGoogle Scholar
  27. Dobbing J, Sands J (1973) Quantitative growth and development of human brain. Arch Dis Child 48:757–767PubMedCrossRefGoogle Scholar
  28. Dobbing J, Sands J (1979) Comparative aspects of the brain growth spurt. Early Hum Dev 3:79–83PubMedCrossRefGoogle Scholar
  29. Dobbing J, Smart JL (1974) Vulnerability of developing brain and behaviour. Br Med Bull 30:164–168PubMedGoogle Scholar
  30. Doria V, Beckmann CF, Arichi T, Merchant N, Groppo M, Turkheimer FE, Counsell SJ, Murgasova M, Aljabar P, Nunes RG, Larkman DJ, Rees G, Edwards AD (2010) Emergence of resting state networks in the preterm human brain. Proc Natl Acad Sci U S A 107:20015–20020PubMedCrossRefGoogle Scholar
  31. Doyle LW, Roberts G, Anderson PJ, Victorian Infant Collaborative Study Group (2010) Outcomes at age 2 years of infants <28 weeks’ gestational age born in Victoria in 2005. J Pediatr 156:49–53.e1PubMedCrossRefGoogle Scholar
  32. Duckles SP, Banner W (1984) Changes in vascular smooth muscle reactivity during development. Annu Rev Pharmacol Toxicol 24:65–83PubMedCrossRefGoogle Scholar
  33. Edlund T, Jessell TM (1999) Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system. Cell 96:211–224PubMedCrossRefGoogle Scholar
  34. Estes WK (ed) (1954) Modern learning theory. A critical analysis of five examples. Appleton-Century-Crofts, Inc., New York, NYGoogle Scholar
  35. Ferriero DM (2004) Neonatal brain injury. N Engl J Med 351:1985–1995PubMedCrossRefGoogle Scholar
  36. Gage FH (2000) Mammalian neural stem cells. Science 287:1433–1438PubMedCrossRefGoogle Scholar
  37. Gage FH (2002) Neurogenesis in the adult brain. J Neurosci 22:612–613PubMedGoogle Scholar
  38. Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJ, Suhonen JO, Peterson DA, Suhr ST, Ray J (1995) Survival and differentiation of adult neuronal progenitory cells transplanted to the adult brain. Proc Natl Acad Sci U S A 92:11879–11883PubMedCrossRefGoogle Scholar
  39. Garcion E, Faissner A, ffrench-Constant C (2001) Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration. Development 128:2485–2496PubMedGoogle Scholar
  40. Goldstein M (1994) Decade of the brain. An agenda for the nineties. West J Med 161:239–241PubMedGoogle Scholar
  41. Goyal R, Longo LD (2012) Gene expression in sheep carotid arteries; changes with maturational development. Pediatr Res 72:137–146PubMedCrossRefGoogle Scholar
  42. Goyal R, Mittal A, Chu N, Shi L, Zhang L, Longo LD (2009) Maturation and the role of PKC-mediated contractility of ovine cerebral arteries. Am J Physiol Heart Circ Physiol 297:H2242–H2252PubMedCrossRefGoogle Scholar
  43. Goyal R, Goyal D, Leitzke A, Gheorghe CP, Longo LD (2010a) Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy. Reprod Sci 17:227–238PubMedCrossRefGoogle Scholar
  44. Goyal R, Mittal A, Chu N, Arthur RA, Zhang L, Longo LD (2010b) Maturation and long-term hypoxia-induced acclimatization responses in PKC-mediated signaling pathways in ovine cerebral arterial contractility. Am J Physiol Regul Integr Comp Physiol 229:R1377–R1386CrossRefGoogle Scholar
  45. Goyal R, Henderson DA, Chu N, Longo LD (2012) Ovine middle cerebral artery changes with development: characterization and quantification of ultrastructure and other features. Am J Physiol Regul Integr Comp Physiol 302:R433–R445PubMedCrossRefGoogle Scholar
  46. Greenough WT, West RW, DeVoogd TJ (1978) Subsynaptic plate perforations: changes with age and experience in the rat. Science 202:1096–1098PubMedCrossRefGoogle Scholar
  47. Groenendaal F, Termote JU, van der Heide-Jalving M, van Haastert IC, de Vries LS (2010) Complications affecting preterm neonates from 1991 to 2006: what have we gained? Acta Paediatr 99:354–358PubMedCrossRefGoogle Scholar
  48. Guillemot F, Molnár Z, Tarabykin V, Stoykova A (2006) Molecular mechanisms of cortical differentiation. Eur J Neurosci 23:857–868PubMedCrossRefGoogle Scholar
  49. Hattori D, Chen Y, Matthews BJ, Salwinski L, Sabatti C, Grueber WB, Zipursky SL (2009) Robust discrimination between self and non-self neuritis requires thousands of Dscam1 isoforms. Nature 461:644–648PubMedCrossRefGoogle Scholar
  50. Hebb DO (1949) The organization of behavior, a neuropsychological theory. Wiley, New York, NYGoogle Scholar
  51. Herrick CJ (1924) Neurological foundations of animal behavior. Henry Holt & Co., New York, NYGoogle Scholar
  52. Herrick CJ (1926) Brains of rats and men: a survey of the origin and biological significance of the cerebral cortex. University of Chicago Press, Chicago, ILCrossRefGoogle Scholar
  53. Herrick CJ (1929) The thinking machine. University of Chicago Press, Chicago, ILCrossRefGoogle Scholar
  54. Herrick CJ (1956) The evolution of human nature. University of Texas Press, Austin, TXGoogle Scholar
  55. Holliday MA (1971) Metabolic rate and organ size during growth from infancy to maturity and during late gestation and early infancy. Pediatrics 47:169–179PubMedGoogle Scholar
  56. Hubel DH (1982) Exploration of the primary visual cortex, 1955–78. Nature 299:515–524PubMedCrossRefGoogle Scholar
  57. Hubel DH, Wiesel TN (1965) Binocular interaction in striate cortex of kittens reared with artificial squint. J Neurophysiol 28:1041–1059PubMedGoogle Scholar
  58. Ingber DE (1997) Tensegrity: the architectural basis of cellular mechanotransduction. Annu Rev Physiol 59:575–599PubMedCrossRefGoogle Scholar
  59. Ingber DE (2003a) Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci 116:1157–1173PubMedCrossRefGoogle Scholar
  60. Ingber DE (2003b) Tensegrity II. How structural networks influence cellular information processing networks. J Cell Sci 116:1397–1408PubMedCrossRefGoogle Scholar
  61. Jacobson M (1970) Developmental neurobiology. Holt, Rinehart and Winston, Inc., New York, NYGoogle Scholar
  62. Jacobson M (1978) Developmental neurobiology, 2nd edn. Holt, Rinehart and Winston, Inc., New York, NYCrossRefGoogle Scholar
  63. Jandó G, Mikó-Baráth E, Markó K, Hollódy K, Török B, Kovacs I (2012) Early-onset binocularity in preterm infants reveals experience-dependent visual development in humans. Proc Natl Acad Sci U S A 109:11049–11052PubMedCrossRefGoogle Scholar
  64. Jeffress LA (ed) (1951) Cerebral mechanisms in behavior. The Hixon symposium. Wiley, New York, NYGoogle Scholar
  65. Jessell TM, Sanes JR (2000) The decade of the developing brain. Curr Opin Neurobiol 10:599–611PubMedCrossRefGoogle Scholar
  66. Jiang Y, Langley B, Lubin FD, Renthal W, Wood MA, Yasui DH, Kumar A, Nestler EJ, Akbarian S, Beckel-Mitchener AC (2008) Epigenetics in the nervous system. J Neurosci 28:11753–11759PubMedCrossRefGoogle Scholar
  67. Johnson S, Hollis C, Kochhar P, Hennessy E, Wolke D, Marlow N (2010) Autism spectrum disorders in extremely preterm children. J Pediatr 156:525–531.e2PubMedCrossRefGoogle Scholar
  68. Kinter C (2002) Neurogenesis in embryos and in adult neural stem cells. J Neurosci 22:639–643Google Scholar
  69. Kosmarskaya EN (1963) The influence of peripheral stimuli on development of the nerve cells. In: Klosovskii BN (ed) The development of the brain and its disturbance by harmful factors. Oxford, Pergamon Press, pp 229–237, Translated from the Russian and edited by B. HaighGoogle Scholar
  70. Kriegstein A, Alvarez-Buylla A (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32:149–184PubMedCrossRefGoogle Scholar
  71. Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH (2009) Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci 12:1097–1105PubMedCrossRefGoogle Scholar
  72. Leffler CW, Nasjletti A, Yu C, Johnson RA, Fedinec AL, Walker N (1999) Carbon monoxide and cerebral microvascular tone in newborn pigs. Am J Physiol 276:H1641–H1646PubMedGoogle Scholar
  73. Leffler CW, Nasjletti A, Johnson RA, Fedinec AL (2001) Contribution of prostacyclin and nitric oxide to carbon monoxide-induced cerebrovascular dilation in piglets. Am J Physiol Heart Circ Physiol 280:H1490–H1495PubMedGoogle Scholar
  74. Leffler CW, Balabanova L, Fedinec AL, Parfenova H (2005) Nitric oxide increases carbon monoxide production by piglet cerebral microvessels. Am J Physiol Heart Circ Physiol 289:H1442–H1447PubMedCrossRefGoogle Scholar
  75. Levitt P (2003) Structural and functional maturation of the developing primate brain. J Pediatr 143:S35–S45PubMedCrossRefGoogle Scholar
  76. Lewis M (ed) (1986) Learning disabilities and prenatal risk. University of Illinois Press, Urbana, ILGoogle Scholar
  77. Lin M, Hessinger DA, Pearce WJ, Longo LD (2003) Developmental differences in Ca2+-activated K+channel activity in ovine basilar artery. Am J Physiol Heart Circ Physiol 285:H701–H709PubMedGoogle Scholar
  78. Lin M, Longo LD, Pearce WJ, Hessinger DA (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activites during development. Am J Physiol Heart Circ Physiol 289:H414–H425PubMedCrossRefGoogle Scholar
  79. Lin M, Hessinger DA, Pearce WJ, Longo LD (2006) Modulation of BK channel calcium affinity by differential phosphorylation in developing ovine basilar artery myocytes. Am J Physiol Heart Circ Physiol 291:H732–H740PubMedCrossRefGoogle Scholar
  80. Long W, Zhao Y, Zhang L, Longo LD (1999) Role of Ca2+ channels in NE-induced increase in [Ca2+]i and tension in fetal and adult cerebral arteries. Am J Physiol 277:R286–R294PubMedGoogle Scholar
  81. Long W, Zhang L, Longo LD (2000a) Cerebral artery sarcoplasmic reticulum Ca2+ stores and contractility: changes with development. Am J Physiol 279:R860–R873Google Scholar
  82. Long W, Zhang L, Longo LD (2000b) Cerebral Artery KATP and KCa channel activity and contractility: changes with development. Am J Physiol 279:R2004–R2014Google Scholar
  83. Longo LD, Goyal R (2013) Invited review. Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity. Curr Vasc Pharmacol (In Press)Google Scholar
  84. Longo LD, Ueno N, Zhao Y, Pearce WJ, Zhang L (1996a) Developmental changes in α1-adrenergic receptors, IP3 responses, and NE-induced contraction in cerebral arteries. Am J Physiol 271:H2313–H2319PubMedGoogle Scholar
  85. Longo LD, Ueno N, Zhao Y, Zhang L, Pearce WJ (1996b) NE-induced contraction, α1-adrenergic receptors, and INS(1,4,5)P3 responses in cerebral arteries. Am J Physiol 270:H915–H923PubMedGoogle Scholar
  86. Longo LD, Zhao Y, Long W, Miguel C, Windemuth RS, Cantwell AM, Nanyonga AT, Saito T, Zhang L (2000) Dual role of PKC in modulating pharmacomechanical coupling in fetal and adult cerebral arteries. Am J Physiol 279:R1419–R1429Google Scholar
  87. Matthews BJ, Kim ME, Flanagan JJ, Hattori D, Clemens JC, Zipursky SL, Grueber WB (2007) Dendrite self-avoidance is controlled by Dscam. Cell 129:593–604PubMedCrossRefGoogle Scholar
  88. McConnell SK (1991) The generation of neuronal diversity in the central nervous system. Annu Rev Neurosci 14:269–300PubMedCrossRefGoogle Scholar
  89. McCulloch WS, Pitts W (1943) A logical calculus of the ideas immanent in nervous activity. Bull Math Biophys 5:115–133CrossRefGoogle Scholar
  90. McIntosh GH, Baghurst KI, Potter BJ, Hetzel BS (1979) Foetal brain development in the sheep. Neuropathol Appl Neurobiol 5:103–114PubMedCrossRefGoogle Scholar
  91. Ming GL, Song H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687–702PubMedCrossRefGoogle Scholar
  92. Minkowski A (1967) Regional development of the brain in early life. F.A. Davis Company, Philadelphia, PAGoogle Scholar
  93. Morgane PJ, Austin-LaFrance R, Bronzino J, Tonkiss J, Diaz-Cintra S, Cintra L, Kemper T, Galler JR (1993) Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev 17:91–128PubMedCrossRefGoogle Scholar
  94. Mountcastle VB (1997) The columnar organization of the neocortex. Brain 120:701–722PubMedCrossRefGoogle Scholar
  95. Msall ME (2010) Central nervous system connectivity after extreme prematurity: understanding autistic spectrum disorder. J Pediatr 156:519–521PubMedCrossRefGoogle Scholar
  96. Munck P, Haataja L, Maunu J, Parkkola R, Rikalainen H, Lapinleimu H, Lehtonen L, PIPARI Study Group (2010) Cognitive outcome at 2 years of age in Finnish infants with very low birth weight born between 2001 and 2006. Acta Paediatr 99:359–366PubMedCrossRefGoogle Scholar
  97. Nauli SM, Ally A, Zhang L, Gerthoffer WT, Pearce WJ (2000) Maturation attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine basilar arteries. Gen Pharmacol 35:107–118PubMedCrossRefGoogle Scholar
  98. Nelson CA, De Haan M, Thomas KM (2006) Neuroscience of cognitive development: the role of experience and the developing brain. Wiley, Hoboken, NJGoogle Scholar
  99. Overton J (1997) Paul Alfred Weiss, March 21, 1898–September 8, 1989. Biogr Mem Natl Acad Sci 72:373–386PubMedGoogle Scholar
  100. Palmer TD, Takahashi J, Gage FH (1997) The adult hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389–404PubMedCrossRefGoogle Scholar
  101. Pearce WJ, Hull AD, Long DM, Longo LD (1991) Developmental changes in ovine cerebral artery composition and reactivity. Am J Physiol 261:R458–R465PubMedGoogle Scholar
  102. Pearce WJ, Duckles SP, Buchholz J (1999) Effects of maturation on adrenergic neurotransmission in ovine cerebral arteries. Am J Physiol 277:R931–R937PubMedGoogle Scholar
  103. Pearce WJ, Williams JM, Chang MM, Gerthoffer WT (2003) ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries. Arch Physiol Biochem 111:36–44PubMedCrossRefGoogle Scholar
  104. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO (1994) A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 51:874–887PubMedCrossRefGoogle Scholar
  105. Piaget J (1936) La naissance de l’intelligence chez l’enfant. Delachaux & Niestlé s.a, Neuchatel, Paris (Also translated as The origin of intelligence in the child. London, Routledge & Paul, 1953)Google Scholar
  106. Piaget J (1937) La construction du réel chez l’enfant. Delachaux & Niestlé, Neuchâtel (Also translated as The construction of reality in the child. New York, Basic Books, 1954)Google Scholar
  107. Preyer WT (1901) The mind of the child. Part I. The senses and the will. Observations concerning the mental development of the human being in the first years of life. D. Appleton and Company, New York, NY, Translated from the Original German by H.W. BrownGoogle Scholar
  108. Preyer WT (1937) Embryonic motility and sensitivity. Society for Research in Child Development, National Research Council, Washington, DC, Translated from the Original German of “Specielle Physiologie des Embryo” by G.E. Coghill & W.K. Legner. Also published in Monogr Soc Res Child Dev 2:i–115, 1937Google Scholar
  109. Price DJ, Kennedy H, Dehay C, Zhou L, Mercier M, Jossin Y, Goffinet AM, Tissir F, Blakey D, Molnár Z (2006) The development of cortical connections. Eur J Neurosci 23:910–920PubMedCrossRefGoogle Scholar
  110. Pryds O (1991) Control of cerebral circulation in the high-risk neonate. Ann Neurol 30:321–329PubMedCrossRefGoogle Scholar
  111. Qian X, Shen Q, Goderie SK, He W, Capela A, Davis AA, Temple S (2000) Timing of CNS cell generation: a programmed sequenced of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28:69–80PubMedCrossRefGoogle Scholar
  112. Raisman G (1969) Neuronal plasticity in the septal nuclei of the adult rat. Brain Res 14:25–48PubMedCrossRefGoogle Scholar
  113. Rakic P (1975) Cell migration and neuronal ectopias in the brain. Birth Defects Orig Artic Ser 11:95–129PubMedGoogle Scholar
  114. Rakic P (1976) Prenatal genesis of connections subserving ocular dominance in the rhesus monkey. Nature 261:467–471PubMedCrossRefGoogle Scholar
  115. Rakic P (1988) Specification of cerebral cortical areas. Science 241:170–176PubMedCrossRefGoogle Scholar
  116. Rakic P (2000) Molecular and cellular mechanisms of neuronal migration: relevance to cortical epilepsies. Adv Neurol 84:1–14PubMedGoogle Scholar
  117. Rakic P (2003) Developmental and evolutionary adaptations of cortical radial glia. Cereb Cortex 13:541–549PubMedCrossRefGoogle Scholar
  118. Rakic P (2005) Less is more: progenitor death and cortical size. Nat Neurosci 8:981–982PubMedCrossRefGoogle Scholar
  119. Rakic P, Riley KP (1983) Regulation of axon number in primate optic nerve by prenatal binocular competition. Nature 305:135–137PubMedCrossRefGoogle Scholar
  120. Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707–1710PubMedCrossRefGoogle Scholar
  121. Richards LJ, Kilpatrick TJ, Bartlett PF (1992) De novo generation of neuronal cells from the adult mouse brain. Proc Natl Acad Sci U S A 89:8591–8595PubMedCrossRefGoogle Scholar
  122. Ringrose L, Paro R (2004) Epigenetic regulation of cellular memory by the polycomb and trithorax group proteins. Annu Rev Genet 38:413–443PubMedCrossRefGoogle Scholar
  123. Rønn LC, Hartz BP, Bock E (1998) The neural cell adhesion molecular (NCAM) in development and plasticity of the nervous system. Exp Gerontol 33:853–864PubMedCrossRefGoogle Scholar
  124. Roofe PG (1971) George Ellett Coghill. In: Gillispie CC (ed) Dictionary of scientific biography, vol 3. New York, NY, Charles Scribner’s Sons, pp 331–332Google Scholar
  125. Sanai N, Nguyen T, Ihrie RA, Mirzadeh Z, Tsai HH, Wong M, Gupta N, Berger MS, Huang E, Garcia-Verdugo JM, Rowitch DH, Alvarez-Buylla A (2011) Corridors of migrating neurons in the human brain and their decline during infancy. Nature 478:382–386PubMedCrossRefGoogle Scholar
  126. Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101:671–684PubMedCrossRefGoogle Scholar
  127. Sheth RD (1998) Trends in incidence and severity of intraventricular hemorrhage. J Child Neurol 13:261–264PubMedCrossRefGoogle Scholar
  128. Smith L, Greenfield A (2003) DNA microarrays and development. Hum Mol Genet 12:R1–R8PubMedCrossRefGoogle Scholar
  129. Snider WD, Lichtman JW (1996) Are neurotrophins synaptotrophins? Mol Cell Neurosci 7:433–442PubMedCrossRefGoogle Scholar
  130. Soler-Llavina GJ, Fuccillo MV, Ko J, Sudhof TC, Malenka RC (2011) The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo. Proc Natl Acad Sci U S A 108:16502–16509PubMedCrossRefGoogle Scholar
  131. Sowell ER, Thompson PM, Leonard CM, Welcome SE, Kan E, Toga AW (2004) Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci 24:8223–8231PubMedCrossRefGoogle Scholar
  132. Sperry RW (1963) Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci U S A 50:703–710PubMedCrossRefGoogle Scholar
  133. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Lapttok AR, Walsh MC, Hale EC, Newman NS, Schibler K, Carlo WA, Kennedy KA, Poindexter BB, Finer NN, Ehrenkranz RA, Duara S, Sanchez PJ, O’Shea TM, Goldberg RN, Van Meurs KP, Faix RG, Phelps DL, Frantz ID III, Watterberg KL, Saha S, Das A, Higgins RD, Eunice Kennedy Shriver National institute of Child Health and Human Development Neonatal Research Network (2010) Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 126:443–456PubMedCrossRefGoogle Scholar
  134. Südhof TC (2008) Neuroligins and neurexins link synaptic function to cognitive disease. Nature 455:903–911PubMedCrossRefGoogle Scholar
  135. Suh H, Consiglio A, Ray J, Sawai T, D’Amour KA, Gage FH (2007) In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell 1:515–528PubMedCrossRefGoogle Scholar
  136. Sur M, Rubenstein JL (2005) Patterning and plasticity of the cerebral cortex. Science 310:805–810PubMedCrossRefGoogle Scholar
  137. Szentágothai J (1978) The Ferrier lecture, 1977. The neuron network of the cerebral cortex: a functional interpretation. Proc R Soc Lond B Biol Sci 201:219–248PubMedCrossRefGoogle Scholar
  138. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T (2001) DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 1:749–758PubMedCrossRefGoogle Scholar
  139. Toda N (1991) Age-related changes in responses to nerve stimulation and catecholamines in isolated monkey cerebral arteries. Am J Physiol 260:H1443–H1448PubMedGoogle Scholar
  140. Torii M, Hashimoto-Torii K, Levitt P, Rakic P (2009) Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signaling. Nature 461:524–528PubMedCrossRefGoogle Scholar
  141. Vannucci RC, Vannucci SJ (2004) Perinatal brain metabolism. In: Polin RA, Fox WW, Abman SH (eds) Fetal and neonatal physiology, vol 2, 3rd edn. Saunders, Philadelphia, PA, pp 1713–1725Google Scholar
  142. Volpe JJ, Kinney HC, Jensen FE, Rosenberg PA (2011) Reprint of “The developing oligodendrocyte: key cellular target in brain injury in the premature infant”. Int J Dev Neurosci 29:565–582PubMedCrossRefGoogle Scholar
  143. Walkerdine V (1987) The mastery of reason: cognitive development and the production of rationality. Routledge, LondonGoogle Scholar
  144. Weiss PA (1951) Discussion of K.S. Lashley. The problem of serial order in behavior. In: Jeffress LA (ed) Cerebral mechanisms in behavior. The Hixon symposium. University of Texas Press, Austin, TX, pp 140–142Google Scholar
  145. Wiesel TN (1982) Postnatal development of the visual cortex and the influence of environment. Nature 299:583–591PubMedCrossRefGoogle Scholar
  146. Wiesel TN, Hubel DH (1963a) Effects of visual deprivation on morphology and physiology of cells in the cat’s lateral geniculate body. J Neurophysiol 26:978–993PubMedGoogle Scholar
  147. Wiesel TN, Hubel DH (1963b) Single-cell responses in striate cortex of kittens deprived of vision in one eye. J Neurophysiol 26:1003–1017PubMedGoogle Scholar
  148. Williams RS (1989) Cerebral malformations arising in the first half of gestation. In: Evrard P, Minkowski A (eds) Developmental neurobiology. Raven, New York, NY, pp 11–20Google Scholar
  149. Williams RW, Herrup K (1988) The control of neuron number. Annu Rev Neurosci 11:423–453PubMedCrossRefGoogle Scholar
  150. Windle WF (1967) Maturation of the brain related to variables in the environment. In: Minkowski A (ed) Regional development of the brain in early life. F.A. Davis Company, Philadelphia, PA, pp 395–409Google Scholar
  151. Windle WF, Fitzgerald JE (1937) Development of the spinal reflex mechanism in human embryos. J Comp Neurol 67:493–509CrossRefGoogle Scholar
  152. Windle WF, Dragstedt CA, Murray DE, Greene RR (1938) A note on the respiration-like movements of the human foetus. Surg Gynecol Obstet 66:987–988Google Scholar
  153. Wojtowicz WM, Wu W, Andre I, Qian B, Baker D, Zipursky SL (2007) A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell 130:1134–1145PubMedCrossRefGoogle Scholar
  154. Yuan TF (2008) GABA effects on neurogenesis: an arsenal of regulation. Sci Signal 1:jc1PubMedCrossRefGoogle Scholar
  155. Zhao C, Deng W, Gage FH (2008) Mechanisms and functional implications of adult neurogenesis. Cell 132:645–660PubMedCrossRefGoogle Scholar
  156. Zipursky SL (2010) Driving self-recognition. Scientist 24:41–45Google Scholar

Copyright information

© American Physiological Society 2013

Authors and Affiliations

  • Lawrence D. Longo
    • 1
  1. 1.Center for Perinatal BiologyLoma Linda University School of MedicineLoma LindaUSA

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