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Mitogen-Activated Protein Kinase Phosphatases in Metabolism

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Protein Tyrosine Phosphatase Control of Metabolism

Abstract

Although we continue to learn much about how the mitogen-activated protein kinases (MAPKs) are involved in physiological and pathophysiological signaling in metabolism, a comparable level of understanding about the mechanisms of MAPK inactivation in the control of metabolic homeostasis is lacking. The family of enzymes known to specifically antagonize the MAPKs by direct dephosphorylation, the MAPK phosphatases (MKPs), are emerging as important players in the control of metabolic homeostasis. The MKPs regulate the MAPKs through a complex network of pathways within a spatio-temporal and tissue-specific manner. Here, we will review studies that have led to the realization that the MKPs play essential signaling roles in the control of metabolic homeostasis by counterbalancing the actions of the MAPKs. A growing body of evidence now demonstrates a critical role for the MKPs in the regulation of MAPK activity in metabolic signaling.

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Abbreviations

DUSP:

Dual-specificity protein phosphatase

ERK1/2:

Extracellular signal-regulated kinases 1 and 2

FOXO:

Forkhead box O protein

G6Pase:

Glucose 6-phosphatase

JNK:

c-Jun NH2 kinases

KIM:

Kinase interaction motif

MAPK:

Mitogen-activated protein kinases

MKP:

MAPK phosphatase

PEPCK:

Phosphoenol pyruvate carboxykinase

PPAR:

Peroxisome proliferator-activated receptor

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Acknowledgments

A.M.B. was supported by NIH grants DK075776 and DK34989. We thank Florian Gatzke for the preparation of illustrations for this review.

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  1. Department of Pharmacology, Yale University School of Medicine, New Haven, CT, 06510, USA

    Ahmed Lawan Ph.D. & Anton M. Bennett Ph.D.

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  1. Ahmed Lawan Ph.D.
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Correspondence to Ahmed Lawan Ph.D. .

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  1. Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Kendra K. Bence

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Lawan, A., Bennett, A.M. (2013). Mitogen-Activated Protein Kinase Phosphatases in Metabolism. In: Bence, K. (eds) Protein Tyrosine Phosphatase Control of Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7855-3_12

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