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The Role of LMPTP in the Metabolic Syndrome

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Book cover Protein Tyrosine Phosphatase Control of Metabolism

Abstract

The low molecular weight class of protein tyrosine phosphatases (PTPs) has been implicated as key modulators of pathways controlling human susceptibility to a host of disorders. As a result, these enzymes are emerging as novel targets for the treatment of a variety of ailments, ranging from cardiovascular disorders to neoplastic syndromes to infectious diseases. For decades evidence has been accumulating that the human low molecular weight PTP (LMPTP) is a key regulator of the metabolic conditions that accompany obesity and can put humans at risk for type 2 diabetes, coronary artery disease, and other, sometimes lethal, complications. While the LMPTP is ubiquitously expressed and involved in numerous signaling pathways controlling cell growth and differentiation, this review will focus on the critical role of LMPTP in regulating insulin resistance and its implications for metabolic homeostasis.

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Abbreviations

ACP1:

Acid phosphatase locus 1

ADA:

Adenosine deaminase

ASO:

Antisense oligonucleotide

BMI:

Body mass index

BPTP:

Bovine heart protein tyrosine phosphatase

CAD:

Coronary artery disease

DIO:

Diet-induced obese

f:

Fast isoform

hAAP:

Human adipocyte acid phosphatase

HCPTP:

Human cytosolic low-molecular-weight protein tyrosine phosphatase

IR:

Insulin receptor

LDL:

Low-density lipoprotein

LMPTP:

Low molecular weight protein tyrosine phosphatase

PTP:

Protein tyrosine phosphatase

s:

Slow isoform

SNP:

Single nucleotide polymorphism

SV3:

Splicing variant 3

T1D:

Type 1 diabetes

T2D:

Type 2 diabetes

ZAP-70:

ζ-chain-associated protein tyrosine phosphatase of 70 kDa

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Authors and Affiliations

  1. Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, USA

    Stephanie M. Stanford Ph.D. & Nunzio Bottini M.D., Ph.D.

  2. Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, La Jolla, CA, 92037, USA

    Massimo Bottini Ph.D.

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  1. Stephanie M. Stanford Ph.D.
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  2. Massimo Bottini Ph.D.
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  3. Nunzio Bottini M.D., Ph.D.
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Correspondence to Nunzio Bottini M.D., Ph.D. .

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  1. Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Kendra K. Bence

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Stanford, S.M., Bottini, M., Bottini, N. (2013). The Role of LMPTP in the Metabolic Syndrome. In: Bence, K. (eds) Protein Tyrosine Phosphatase Control of Metabolism. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7855-3_11

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