Livedo reticularis (LR) is a common physical finding consisting of a mottled, reticulated vascular pattern resulting from alterations in blood flow through the cutaneous microvasculature system. It can be benign, occurring in healthy individuals without systemic associations, or it may be secondary, occurring in association with underlying disease. Livedo reticularis can manifest by any process that reduces arteriole blood flow or venous outflow, leading to accumulation of deoxygenated venous blood. Physiologic, primary, and idiopathic LR occur without systemic associations. Systemic associations with LR include autoimmune connective tissue disease, vasospasm, vessel obstruction, medications, infections, neoplasms, and congenital, hematologic, and neurologic causes.
Skin Biopsy Physical Exam Polycythemia Vera Mycosis Fungoides Venous Outflow
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Diagnostic Flow Chart 1 based on data from Gibbs MB, English JC, Zirwas MJ. Livedo reticularis: an update. J Am Acad Dermatol. 2005;Jun;52(6):1009–1019.
Speight EL, Lawrence CM. Reticulate purpura, cryoglobulinaemia and livedo reticularis. Br J Dermatol. 1993;129(3):319–23.PubMedCrossRefGoogle Scholar
Filo V, Brezova D, Hlavcak P, Filova A. Livedo reticularis as a presenting symptom of polycythaemia vera. Clin Exp Dermatol. 1999;24(5):428.PubMedCrossRefGoogle Scholar
Frances C, Niang S, Laffitte E, Pelletier F, Costedoat N, Piette JC. Dermatologic manifestations of the antiphospholipid syndrome: two hundred consecutive cases. Arthritis Rheum. 2005;52(6):1785–93.PubMedCrossRefGoogle Scholar
Kriseman YL, Nash JW, Hsu S. Criteria for the diagnosis of antiphospholipid syndrome in patients presenting with dermatologic symptoms. J Am Acad Dermatol. 2007;57(1):112–5.PubMedCrossRefGoogle Scholar
Frances C. Dermatological manifestations of Hughes’ antiphospholipid antibody syndrome. Lupus. 2010;19(9):1071–7.PubMedCrossRefGoogle Scholar
Kraemer M, Linden D, Berlit P. The spectrum of differential diagnosis in neurological patients with livedo reticularis and livedo racemosa. A literature review. J Neurol. 2005;252(10):1155–66.PubMedCrossRefGoogle Scholar
Bosco L, Peroni A, Schena D, Colato C, Girolomoni G. Cutaneous manifestations of Churg-Strauss syndrome: report of two cases and review of the literature. Clin Rheumatol. 2011;30(4):573–80.PubMedCrossRefGoogle Scholar
Dion J, Bachmeyer C, Moguelet P, Lescure FX, Pagnoux C. Livedo reticularis and erythematous macules of the forearms indicating cutaneous microscopic polyangiitis. Am J Med. 2010;123(11):e5–6.PubMedCrossRefGoogle Scholar
Chaudhary K, Wall BM, Rasberry RD. Livedo reticularis: an underutilized diagnostic clue in cholesterol embolization syndrome. Am J Med Sci. 2001;321(5):348–51.PubMedCrossRefGoogle Scholar
Izumi AK, Samlaska CP, Hew DW, Bruno PP. Septic embolization arising from infected pseudoaneurysms following percutaneous transluminal coronary angioplasty: a report of 2 cases and review of the literature. Cutis Cutan Med Pract. 2000;66(6):447–52.Google Scholar
Blackmon JA, Jeffy BG, Malone JC, Knable Jr AL. Oxalosis involving the skin: case report and literature review. Arch Dermatol. 2011;147:1302–5.PubMedCrossRefGoogle Scholar