Skin Manifestations in Microscopic Polyangiitis

  • Nicolò Pipitone
  • Carlo SalvaraniEmail author
  • Gene G. Hunder


Microscopic polyangiitis is a pauci-immune necrotizing small- and medium-vessel vasculitis mainly involving the lung and kidneys but also the peripheral nerves and skin. A variety of skin lesions are observed in about half of patients. The most common cutaneous manifestations are palpable purpura, livedo racemosa, and skin nodules. Histology of skin lesions typically shows leukocytoclasia with fibrinoid degeneration, neutrophil infiltration, and sometimes erythrocyte extravasation around the affected capillaries and small vessels in the dermis. Direct immunofluorescence shows absence of immunoglobulin deposits. A detailed clinical history and physical examination complemented by histological studies can aid in discriminating microscopic polyangiitis from other vasculitides affecting the skin.


Pyoderma Gangrenosum Polyarteritis Nodosa Cutaneous Manifestation Lepromatous Leprosy Palpable Purpura 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Nicolò Pipitone
    • 1
  • Carlo Salvarani
    • 1
    Email author
  • Gene G. Hunder
    • 2
  1. 1.Department of Rheumatology, Division of MedicineArcispedale Santa Maria NuovaReggio EmiliaItaly
  2. 2.Emeritus Staff CenterMayo ClinicRochesterUSA

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