Graft-Versus-Host Disease (GvHD): Cutaneous Manifestations
Graft-versus-host disease (GvHD) is the major immunological, mainly donor T-cell-derived, complication after allogeneic hematopoietic stem cell transplantation. GvHD occurs in about 50 % of patients and is directly related to the degree of mismatch between HLA proteins of host and donor. Fast-proliferating organs such as skin, liver, and gastrointestinal tract are predominantly involved. Cutaneous manifestations are broad and mucous membranes and adnexal structures can be affected as well. Today, acute GvHD is divided into classic, persistent, recurrent, or late-onset disease, and chronic GvHD is categorized as classical or overlap syndrome.
KeywordsAtopic Dermatitis Systemic Sclerosis Acute GvHD Allogeneic Hematopoietic Stem Cell Transplantation Chronic GvHD
- 4.Wagner JL, Murphy GF. Pathology and pathogenesis of cutaneous graft-versus-host disease. In: Ferrara JLM, Cooke KR, Deeg HJ, editors. Graft-vs-host disease. 3rd ed. New York: Marcel Dekker; 2005. p. 229–57.Google Scholar
- 6.Filipovitch AH et al. 14. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report, Biol Blood Marrow Transplant. 2005;11:945.Google Scholar
- 9.Shulman HM, et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in chronic Graft-versus-Host Disease: II. Pathology working Group Report. Biol Blood Marrow Transplant. 2006;12:31.PubMedCrossRefGoogle Scholar