Graft-Versus-Host Disease (GvHD): Cutaneous Manifestations

  • Peter HäusermannEmail author
  • Alan Tyndall


Graft-versus-host disease (GvHD) is the major immunological, mainly donor T-cell-derived, complication after allogeneic hematopoietic stem cell transplantation. GvHD occurs in about 50 % of patients and is directly related to the degree of mismatch between HLA proteins of host and donor. Fast-proliferating organs such as skin, liver, and gastrointestinal tract are predominantly involved. Cutaneous manifestations are broad and mucous membranes and adnexal structures can be affected as well. Today, acute GvHD is divided into classic, persistent, recurrent, or late-onset disease, and chronic GvHD is categorized as classical or overlap syndrome.


Atopic Dermatitis Systemic Sclerosis Acute GvHD Allogeneic Hematopoietic Stem Cell Transplantation Chronic GvHD 
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© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.Department of DermatologyUniversity Hospital BaselBaselSwitzerland
  2. 2.Department of Rheumatology, Felix Platter SpitalUniversity Hospital BaselBaselSwitzerland

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