Advertisement

Skin Manifestations of Neonatal Lupus Erythematosus

  • Ivan Foeldvari
  • Kristian ReichEmail author
Chapter

Abstract

Neonatal lupus erythematosus is characterized by annular or plaque-type erythemato-squamous skin lesions usually of the face and scalp that develop in 2–10 % of children of anti-SSA/Ro- or anti-SSB/La-positive mothers at birth or, more often, within the first weeks of life. Some children have periorbital erythemas. The skin lesions usually resolve spontaneously within weeks to months; the persistence of telangiectasia or postinflammatory hyperpigmentations is rare. In one third of the children with skin symptoms, other organ systems are involved with the risk of an atrioventricular block, elevated liver enzymes, hyperbilirubinemia, and decreased numbers of peripheral lymphocytes or thrombocytes. The most threatening manifestation is a grade III AV block which may require pacemaker placement. In known anti-Ro antibody-positive mothers, the respective diagnosis and, if needed, appropriate therapy can be performed in utero, and a preventive therapy of other manifestations of neonatal lupus with corticosteroids may be considered.

Keywords

Cutaneous Lupus Erythematosus Seborrheic Eczema Subacute Cutaneous Lupus Erythematosus Congenital Syphilis Neonatal Lupus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Renner R, Sticherling M. The different faces of cutaneous lupus erythematosus. G Ital Dermatol Venereol. 2009;144(2):135–47.PubMedGoogle Scholar
  2. 2.
    Lee LA. The clinical spectrum of neonatal lupus. Arch Dermatol Res. 2009;301(1):107–10.PubMedCrossRefGoogle Scholar
  3. 3.
    Klauninger R, Skog A, et al. Serologic follow-up of children born to mothers with Ro/SSA autoantibodies. Lupus. 2009;18(9):792–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Buyon JP. Updates on lupus and pregnancy. Bull NYU Hosp Jt Dis. 2009;67(3):271–5.PubMedGoogle Scholar
  5. 5.
    Penate Y, Guillermo N, et al. Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review. J Cutan Pathol. 2009;36(6):660–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Lee LA, Gaither KK, et al. Pattern of cutaneous immunoglobulin G deposition in subacute cutaneous lupus erythematosus is reproduced by infusing purified anti-Ro (SSA) autoantibodies into human skin-grafted mice. J Clin Invest. 1989;83(5):1556–62.PubMedCrossRefGoogle Scholar
  7. 7.
    Satter EK, High WA. Non-bullous neutrophilic dermatosis within neonatal lupus erythematosus. J Cutan Pathol. 2007;34(12):958–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.Hamburger Zentrum für Kinder- und JugendrheumatologieHamburgGermany
  2. 2.Dermatologikum HamburgHamburgGermany

Personalised recommendations