Use of Biopsy

  • Flavia Fedeles
  • Jane M. Grant-KelsEmail author


The skin is an important organ involved in rheumatic diseases. A skin biopsy can be a very helpful technique in the diagnosis of various rheumatic diseases if performed adequately in the right clinical setting. This chapter provides practical information about the use of skin biopsy in rheumatic diseases, outlining biopsy techniques, site selection, potential results, and complications.


Systemic Lupus Erythematosus Skin Biopsy Allergic Contact Dermatitis Punch Biopsy Pyoderma Gangrenosum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Ton E, Kruize AA. How to perform and analyse biopsies in relation to connective tissue diseases. Best Pract Res Clin Rheumatol. 2009;23(2):233–55.PubMedCrossRefGoogle Scholar
  2. 2.
    SBaH KM. How to maximize information from a skin biopsy. In: Smaller BR, Hiatt KM, editors. Dermatopathology: the basics. New York: Springer; 2009. p. 37–61.Google Scholar
  3. 3.
    SRaPT CMI. Lupus erythematosus. In: Sontheimer RD, Provost TT, editors. Cutaneous manifestations of rheumatic diseases. Philadelphia: Lippincott Williams & Wilkins; 2004.Google Scholar
  4. 4.
    Kruize AA, Bijlsma JW. Procedures related to connective tissue disease. Best Pract Res Clin Rheumatol. Jun 2005;19(3):417–36.PubMedCrossRefGoogle Scholar
  5. 5.
    Nischal U, Nischal K, Khopkar U. Techniques of skin biopsy and practical considerations. J Cutan Aesthet Surg. 2008;1(2):107–11.PubMedCrossRefGoogle Scholar
  6. 6.
    Alguire PC, Mathes BM. Skin biopsy techniques for the internist. J Gen Intern Med. 1998;13(1):46–54.PubMedCrossRefGoogle Scholar
  7. 7.
    Neitzel CD. Biopsy techniques for skin disease and skin cancer. Oral Maxillofac Surg Clin North Am. 2005;17(2):143–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Ha CT, Nousari HC. Surgical pearl: double-trephine punch biopsy technique for sampling subcutaneous tissue. J Am Acad Dermatol. 2003;48(4):609–10.PubMedCrossRefGoogle Scholar
  9. 9.
    Carlson JA. The histological assessment of cutaneous vasculitis. Histopathology. 2010;56(1):3–23.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.Department of DermatologyRhode Island Hospital/Warren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Dermatology DepartmentUniversity of CT Health CenterFarmingtonUSA

Personalised recommendations