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Advances in HIV-1 Assembly and Release pp 55–73Cite as

Packaging of the HIV-1 RNA Genome

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Abstract

Encapsidating the viral genome into virions is an essential step in generating infectious viral particles. Most HIV-1 particles contain two copies of full-length viral RNA indicating genome encapsidation is an efficient and regulated process. Interactions between the HIV-1 structural protein Gag and cis-acting elements in the viral RNA mediate the packaging of viral RNA. The HIV-1 genome selects its copackaged RNA partner, or dimerizes, prior to encapsidation. Several aspects of virus biology and host–virus interactions important for the packaging of HIV-1 viral genomes are discussed in this review.

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Authors and Affiliations

  1. HIV Drug Resistance Program, Viral Recombination Section, National Cancer Institute, Frederick, MD, 21702, USA

    Jianbo Chen Ph.D., Olga A. Nikolaitchik Ph.D. & Kari A. Dilley Ph.D.

  2. HIV Drug Resistance Program, National Cancer Institute, 1050 Boyles Street, Building 535, Room 336, Frederick, MD, 21702, USA

    Wei-Shau Hu Ph.D.

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  1. Jianbo Chen Ph.D.
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  2. Olga A. Nikolaitchik Ph.D.
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  3. Kari A. Dilley Ph.D.
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  4. Wei-Shau Hu Ph.D.
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Correspondence to Wei-Shau Hu Ph.D. .

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  1. HIV Drug Resistance Program, National Cancer Institute-Frederick, Bg. 535/Rm. 108, Frederick, 21702-1201, Maryland, USA

    Eric O. Freed

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Chen, J., Nikolaitchik, O.A., Dilley, K.A., Hu, WS. (2013). Packaging of the HIV-1 RNA Genome. In: Freed, E. (eds) Advances in HIV-1 Assembly and Release. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7729-7_3

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