Abstract
Although many people believe that the American biologist James Watson and English physicist Francis Crick were the first to discover DNA in the 1950s, DNA was actually discovered by the Swiss chemist Friedrich Miescher in the late 1860s during his attempts to isolate the protein components of leukocytes. But when he isolated a substance that was unlike proteins resistant to proteolysis and also had different chemical properties of proteins, including a much higher phosphorous content, he realized that he had discovered a new substance [1]. He called this new substance “nuclein.”
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References
Dahm, R. (2008). Discovering DNA: Friedrich Miescher and the early years of nucleic acid research. Human Genetics, 122(6), 565–581.
Pray, L. (2008). Discovery of DNA structure and function: Watson and Crick. Nature Education, 1(1) http://www.nature.com/scitable/topicpage/discovery-of-dna-structure-and-function-watson-397.
Chargaff, E. (1950). Chemical specificity of nucleic acids and mechanism of their enzymatic degradation. Cellular and Molecular Life Sciences, 6(6), 201–209.
Nowrousian, M. (2010). Next-generation sequencing techniques for eukaryotic microorganisms: Sequencing-based solutions to biological problems. Eukaryotic Cell, 9(9), 1300–1310.
Mardis, E. R. (2008). Next-generation DNA sequencing methods. Annual Review of Genomics and Human Genetics, 9, 387–402.
Shendure, J., et al. (2004). Advanced sequencing technologies: Methods and goals. Nature Reviews Genetics, 5(5), 335–344.
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Masoudi-Nejad, A., Narimani, Z., Hosseinkhan, N. (2013). Next-Generation Sequencing Methodologies. In: Next Generation Sequencing and Sequence Assembly. SpringerBriefs in Systems Biology, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7726-6_1
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DOI: https://doi.org/10.1007/978-1-4614-7726-6_1
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