Skip to main content

Basics of the Mammalian Immune System

  • Chapter
  • First Online:
  • 1905 Accesses

Part of the book series: Systems Biology ((SYSTBIOL,volume 3))

Abstract

The immune system of living organisms is a highly complex and sophisticated response machinery that protects the host from a diverse range of invading pathogens. It also helps to neutralize any toxic or allergenic substances that enter the host. Today, the creation of a new scientific and therapeutic field, tumor or cancer immunology, to combat malignant cancers through the use of immune cell response demonstrates the crucial importance of the immune system in the survival, adaption, and existence of living organisms.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Finn OJ (2008) Cancer immunology. N Engl J Med 358:2704–2715

    Article  PubMed  CAS  Google Scholar 

  2. Elgert KD (2009) Immunology: understanding the immune system, 2nd edn. Wiley-Blackwell, New York

    Google Scholar 

  3. Dranoff G (2004) Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 4:11–22

    Article  PubMed  CAS  Google Scholar 

  4. Rose NR, Mackay IR (eds) (2006) The autoimmune diseases, 4th edn. Elsevier-Academic Press, New York

    Google Scholar 

  5. Krishnan J, Selvarajoo K, Tsuchiya M, Lee G, Choi S (2007) Toll-like receptor signal transduction. Exp Mol Med 39:421–438

    Article  PubMed  CAS  Google Scholar 

  6. Kapsenberg ML (2003) Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 3:984–993

    Article  PubMed  CAS  Google Scholar 

  7. Romagne F (2007) Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors. Drug Discov Today 12:80–87

    Article  PubMed  CAS  Google Scholar 

  8. Liew FY, Xu D, Brint EK, O’Neill LA (2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 5:446–458

    Article  PubMed  CAS  Google Scholar 

  9. Salaun B, Romero P, Lebecque S (2007) Toll-like receptors’ two-edged sword: when immunity meets apoptosis. Eur J Immunol 37:3311–3318

    Article  PubMed  CAS  Google Scholar 

  10. O’Neill LA, Bryant CE, Doyle SL (2009) Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev 61:177–197

    Article  PubMed  Google Scholar 

  11. Nilsson R, Bajic VB, Suzuki H, di Bernardo D, Björkegren J, Katayama S, Reid JF, Sweet MJ, Gariboldi M, Carninci P, Hayashizaki Y, Hume DA, Tegner J, Ravasi T (2006) Transcriptional network dynamics in macrophage activation. Genomics 88:133–142

    Article  PubMed  CAS  Google Scholar 

  12. Selvarajoo K (2006) Discovering differential activation machinery of the Toll-like receptor 4 signaling pathways in MyD88 knockouts. FEBS Lett 580:1457–1464

    Article  PubMed  CAS  Google Scholar 

  13. Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298:1241–1245

    Article  PubMed  CAS  Google Scholar 

  14. Chen J, Nag S, Vidi PA, Irudayaraj J (2011) Single molecule in vivo analysis of Toll-like receptor 9 and CpG DNA interaction. PLoS One 6:e17991

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Selvarajoo, K. (2013). Basics of the Mammalian Immune System. In: Immuno Systems Biology. Systems Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7690-0_3

Download citation

Publish with us

Policies and ethics