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Finding Chaos in Biology

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Immuno Systems Biology

Part of the book series: Systems Biology ((SYSTBIOL,volume 3))

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Abstract

The preceding chapters have indicated that biology should be appreciated from both microscopic (uncertainty) and macroscopic (certainty) perspectives. For instance, although the control of stochasticity led to a distinct cell fate in the competence of Bacillus subtilis and incomplete penetrance of Caenorhabditis elegans, the nuclear reprogramming by eggs and oocytes is deterministic, as it occurs in an ordered and precise timing. Furthermore, the early events of reprogramming mouse embryonic fibroblasts to pluripotency factor colonies also showed deterministic, rather than stochastic, steps. In contrast to probability theories, these works suggest that well-defined deterministic processes must exist within the noisy cellular environment. Hence, the circumstances in which cells utilize noise (single cell) on the deterministic (population) process remains unclear. As such, it is worthwhile to investigate further underlying mechanisms, apart from causal networks shown in Chap. 8, which could utilize biological noise to change decisions.

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Authors and Affiliations

  1. Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata, Japan

    Kumar Selvarajoo

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  1. Kumar Selvarajoo
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Selvarajoo, K. (2013). Finding Chaos in Biology. In: Immuno Systems Biology. Systems Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7690-0_12

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