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Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure

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Book cover Biophysics of the Failing Heart

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a highly interconnected network of tubules (free SR) and cisterns (junctional SR). Although the SR occupies only 2–4 % of the total cell volume [1], it provides the major portion of Ca that initiates contraction. The ability of the SR to accumulate large amounts of Ca is ensured by the SR-specific low affinity and high capacity Ca binding protein calsequestrin (CASQ) [2].

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Acknowledgements

The authors also would like to thank Drs. Elisa Bovo, Seth L. Robia, Joshua Maxwell, and Ms. Yukiko Kunitomo for critical reading of the manuscript.

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Authors and Affiliations

  1. Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA

    Aleksey V. Zima

  2. Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, USA

    Dmitry Terentyev

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  1. Aleksey V. Zima
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  2. Dmitry Terentyev
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Correspondence to Aleksey V. Zima .

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Editors and Affiliations

  1. Dept. of Physiology & Biophysics, University of Illinois at Chicago, Chicago, USA

    R. John Solaro

  2. University of Arizona, Tucson, Arizona, USA

    Jil C. Tardiff

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Zima, A.V., Terentyev, D. (2013). Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure. In: Solaro, R., Tardiff, J. (eds) Biophysics of the Failing Heart. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7678-8_2

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