Sarcomeres and the Biophysics of Heart Failure

  • Jillian N. Simon
  • Jil C. Tardiff
  • Beata M. Wolska
Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)


Changes in the function of the sarcomere play a significant role in the development of cardiac dysfunction underlying heart failure. These changes in sarcomeric properties are the result of either alterations in isoform expression, post-translational modification of the sarcomeric proteins, or gene mutations linked to hypertrophic or dilated cardiomyopathy. These alterations act to modulate the contractile state of the heart via direct effects on the biophysical properties of the cardiac sarcomere. Coupling a deeper understanding of the primary biophysical causes of changes in contractile function to a more complete understanding of the resultant pathogenic ventricular remodeling that occurs over time will allow for both significant advances in disease management and new points of therapeutic intervention.


Thin Filament Myosin Head Calcium Sensitivity Duty Ratio Regulatory Light Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Jillian N. Simon
    • 1
  • Jil C. Tardiff
    • 2
  • Beata M. Wolska
    • 3
  1. 1.Department of Physiology and BiophysicsUniversity of Illinois at ChicagoChicagoUSA
  2. 2.University of ArizonaTucsonUSA
  3. 3.Department of Medicine, Section of Cardiology and Department of Physiology and Biophysics, Center for Cardiovascular ResearchUniversity of IllinoisChicagoUSA

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