Memory Loss After Stroke

  • Signy SheldonEmail author
  • Gordon Winocur


Memory loss is one of the most common types of cognitive impairment affecting patients after stroke. Memory and related deficits are most severe in the first few weeks following stroke, but can persist for years after the episode [1–3]. The result is a reduction in quality of life, including decreased abilities in performing daily activities and in returning to the workplace [4, 5]. In one quarter of stroke survivors, impairments worsen and develop into dementia, a neurodegenerative condition marked by a range of cognitive deficits [6, 7]. Recent data show that the risk of developing dementia after ischemic stroke is higher than age- and education-matched healthy controls, suggesting common risk factors or some underlying common pathophysiologic mechanisms.


Episodic Memory Vascular Dementia Medial Temporal Lobe Stroke Survivor Retrograde Amnesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Rasquin SM, Verhey FR, Lousberg R, Winkens I, Lodder J. Vascular cognitive disorders: memory, mental speed and cognitive flexibility after stroke. J Neurol Sci. 2002;203–204:115–9. PubMed PMID: 12417368. Epub 2002/11/06. eng.CrossRefPubMedGoogle Scholar
  2. 2.
    Rasquin SM, Lodder J, Ponds RW, Winkens I, Jolles J, Verhey FR. Cognitive functioning after stroke: a one-year follow-up study. Dement Geriatr Cogn Disord. 2004;18(2):138–44. PubMed PMID: 15211068. Epub 2004/06/24. eng.CrossRefPubMedGoogle Scholar
  3. 3.
    Stewart FM, Sunderland A, Sluman SM. The nature and prevalence of memory disorder late after stroke. Br J Clin Psychol. 1996;35(Pt 3):369–79. PubMed PMID: 8889078. Epub 1996/09/01. eng.CrossRefPubMedGoogle Scholar
  4. 4.
    Haacke C, Althaus A, Spottke A, Siebert U, Back T, Dodel R. Long-term outcome after stroke: evaluating health-related quality of life using utility measurements. Stroke. 2006;37(1):193–8. PubMed PMID: 16339458. Epub 2005/12/13. eng.CrossRefPubMedGoogle Scholar
  5. 5.
    Kotila M, Waltimo O, Niemi ML, Laaksonen R, Lempinen M. The profile of recovery from stroke and factors influencing outcome. Stroke. 1984;15(6):1039–44. PubMed PMID: 6506115. Epub 1984/11/01. eng.CrossRefPubMedGoogle Scholar
  6. 6.
    Tatemichi TK, Foulkes MA, Mohr JP, Hewitt JR, Hier DB, Price TR, et al. Dementia in stroke survivors in the stroke data bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings. Stroke. 1990;21(6):858–66. PubMed PMID: 2349588. Epub 1990/06/01. eng.CrossRefPubMedGoogle Scholar
  7. 7.
    Knopman DS. Cerebrovascular disease and dementia. Br J Radiol. 2007;80:S121–7. PubMed PMID: 18445742. Epub 2008/05/01. eng.CrossRefPubMedGoogle Scholar
  8. 8.
    Kopelman MD. Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients. Neuropsychologia. 1989;27(4):437–60. PubMed PMID: 2733818. Epub 1989/01/01. eng.CrossRefPubMedGoogle Scholar
  9. 9.
    Jefferies E, Lambon Ralph MA. Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain. 2006;129(Pt 8):2132–47. PubMed PMID: 16815878. Epub 2006/07/04. eng.CrossRefPubMedGoogle Scholar
  10. 10.
    Chertkow H, Bub D, Deaudon C, Whitehead V. On the status of object concepts in aphasia. Brain Lang. 1997;58(2):203–32. PubMed PMID: 9182748. Epub 1997/06/15. eng.CrossRefPubMedGoogle Scholar
  11. 11.
    Corbett F, Jefferies E, Ehsan S, Lambon Ralph MA. Different impairments of semantic cognition in semantic dementia and semantic aphasia: evidence from the non-verbal domain. Brain. 2009;132(Pt 9):2593–608. PubMed PMID: 19506072. Epub 2009/06/10. eng.CrossRefPubMedGoogle Scholar
  12. 12.
    Squire LR. Memory systems of the brain: a brief history and current perspective. Neurobiol Learn Mem. 2004;82(3):171–7. PubMed PMID: 15464402. Epub 2004/10/07. eng.CrossRefPubMedGoogle Scholar
  13. 13.
    Bondi MW, Kaszniak AW. Implicit and explicit memory in Alzheimer’s disease and Parkinson’s disease. J Clin Exp Neuropsychol. 1991;13(2):339–58. PubMed PMID: 1864919. Epub 1991/03/01. eng.CrossRefPubMedGoogle Scholar
  14. 14.
    Roncacci S, Troisi E, Carlesimo GA, Nocentini U, Caltagirone C. Implicit memory in parkinsonian patients: evidence for deficient skill learning. Eur Neurol. 1996;36(3):154–9. PubMed PMID: 8738946. Epub 1996/01/01. eng.CrossRefPubMedGoogle Scholar
  15. 15.
    Laforce Jr R, Doyon J. Distinct contribution of the striatum and cerebellum to motor learning. Brain Cogn. 2001;45(2):189–211. PubMed PMID: 11237366. Epub 2001/03/10. eng.CrossRefPubMedGoogle Scholar
  16. 16.
    Nikonenko AG, Radenovic L, Andjus PR, Skibo GG. Structural features of ischemic damage in the hippocampus. Anat Rec. 2009;292(12):1914–21. PubMed PMID: 19943345. Epub 2009/11/28. eng.CrossRefGoogle Scholar
  17. 17.
    Moscovitch M, Nadel L, Winocur G, Gilboa A, Rosenbaum RS. The cognitive neuroscience of remote episodic, semantic and spatial memory. Curr Opin Neurobiol. 2006;16(2):179–90. PubMed PMID: 16564688. Epub 2006/03/28. eng.CrossRefPubMedGoogle Scholar
  18. 18.
    Eichenbaum H. A cortical-hippocampal system for declarative memory. Nat Rev Neurosci. 2000;1(1):41–50. PubMed PMID: 11252767. Epub 2001/03/17. eng.CrossRefPubMedGoogle Scholar
  19. 19.
    Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957;20(1):11–21. PubMed PMID: 13406589. Epub 1957/02/01. eng.CrossRefPubMedGoogle Scholar
  20. 20.
    Squire LR. The legacy of patient H.M. For neuroscience. Neuron. 2009;61(1):6–9. PubMed PMID: 19146808. Epub 2009/01/17. eng.CrossRefPubMedGoogle Scholar
  21. 21.
    Vargha-Khadem F, Gadian DG, Watkins KE, Connelly A, Van Paesschen W, Mishkin M. Differential effects of early hippocampal pathology on episodic and semantic memory. Science. 1997;277(5324):376–80. PubMed PMID: 9219696. Epub 1997/07/18. eng.CrossRefPubMedGoogle Scholar
  22. 22.
    Viskontas IV, Carr VA, Engel SA, Knowlton BJ. The neural correlates of recollection: hippocampal activation declines as episodic memory fades. Hippocampus. 2009;19(3):265–72. PubMed PMID: 18830998. Epub 2008/10/03. eng.CrossRefPubMedGoogle Scholar
  23. 23.
    Yonelinas AP, Kroll NE, Quamme JR, Lazzara MM, Sauve MJ, Widaman KF, et al. Effects of extensive temporal lobe damage or mild hypoxia on recollection and familiarity. Nat Neurosci. 2002;5(11):1236–41. PubMed PMID: 12379865. Epub 2002/10/16. eng.CrossRefPubMedGoogle Scholar
  24. 24.
    Spiers HJ, Maguire EA, Burgess N. Hippocampal amnesia. Neurocase. 2001;7(5):357–82. PubMed PMID: 11744778. Epub 2001/12/18. eng.CrossRefPubMedGoogle Scholar
  25. 25.
    Rosenbaum RS, Kohler S, Schacter DL, Moscovitch M, Westmacott R, Black SE, et al. The case of K.C.: contributions of a memory-impaired person to memory theory. Neuropsychologia. 2005;43(7):989–1021. PubMed PMID: 15769487. Epub 2005/03/17. eng.CrossRefPubMedGoogle Scholar
  26. 26.
    Nadel L, Moscovitch M. Memory consolidation, retrograde amnesia and the hippocampal complex. Curr Opin Neurobiol. 1997;7(2):217–27. PubMed PMID: 9142752. Epub 1997/04/01. eng.CrossRefPubMedGoogle Scholar
  27. 27.
    Ott BR, Saver JL. Unilateral amnesic stroke. Six new cases and a review of the literature. Stroke. 1993;24(7):1033–42. PubMed PMID: 8322379. Epub 1993/07/01. eng.CrossRefPubMedGoogle Scholar
  28. 28.
    Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. 1986;6(10):2950–67. PubMed PMID: 3760943. Epub 1986/10/01. eng.PubMedGoogle Scholar
  29. 29.
    Szabo K, Forster A, Jager T, Kern R, Griebe M, Hennerici MG, et al. Hippocampal lesion patterns in acute posterior cerebral artery stroke: clinical and MRI findings. Stroke. 2009;40(6):2042–5. PubMed PMID: 19359650. Epub 2009/04/11. eng.CrossRefPubMedGoogle Scholar
  30. 30.
    Mayes AR, Holdstock JS, Isaac CL, Montaldi D, Grigor J, Gummer A, et al. Associative recognition in a patient with selective hippocampal lesions and relatively normal item recognition. Hippocampus. 2004;14(6):763–84. PubMed PMID: 15318334. Epub 2004/08/20. eng.CrossRefPubMedGoogle Scholar
  31. 31.
    Kitchener EG, Hodges JR, McCarthy R. Acquisition of post-morbid vocabulary and semantic facts in the absence of episodic memory. Brain. 1998;121(Pt 7):1313–27. PubMed PMID: 9679783. Epub 1998/07/29. eng.CrossRefPubMedGoogle Scholar
  32. 32.
    Batchelor S, Thompson EO, Miller LA. Retrograde memory after unilateral stroke. Cortex. 2008;44(2):170–8. PubMed PMID: 18387546. Epub 2008/04/05. eng.CrossRefPubMedGoogle Scholar
  33. 33.
    Aggleton JP, Brown MW. Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav Brain Sci. 1999;22(3):425–44; discussion 444–89. PubMed PMID: 11301518. Epub 2001/04/17. eng.Google Scholar
  34. 34.
    Squire LR, Wixted JT, Clark RE. Recognition memory and the medial temporal lobe: a new perspective. Nat Rev Neurosci. 2007;8(11):872–83. PubMed PMID: 17948032. Epub 2007/10/20. eng.CrossRefPubMedGoogle Scholar
  35. 35.
    Schouten EA, Schiemanck SK, Brand N, Post MW. Long-term deficits in episodic memory after ischemic stroke: evaluation and prediction of verbal and visual memory performance based on lesion characteristics. J Stroke Cerebrovasc Dis. 2009;18(2):128–38. PubMed PMID: 19251189. Epub 2009/03/03. eng.CrossRefPubMedGoogle Scholar
  36. 36.
    Aradillas E, Libon DJ, Schwartzman RJ. Acute loss of spatial navigational skills in a case of a right posterior hippocampus stroke. J Neurol Sci. 2011;308(1–2):144–6. PubMed PMID: 21762930. Epub 2011/07/19. eng.CrossRefPubMedGoogle Scholar
  37. 37.
    Aggleton JP, Saunders RC. The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia. Memory. 1997;5(1–2):49–71. PubMed PMID: 9156091. Epub 1997/01/01. eng.CrossRefPubMedGoogle Scholar
  38. 38.
    Graff-Radford NR, Tranel D, Van Hoesen GW, Brandt JP. Diencephalic amnesia. Brain. 1990;113(Pt 1):1–25. PubMed PMID: 2302527. Epub 1990/02/01. eng.CrossRefPubMedGoogle Scholar
  39. 39.
    Carlesimo GA, Lombardi MG, Caltagirone C. Vascular thalamic amnesia: a reappraisal. Neuropsychologia. 2011;49(5):777–89. PubMed PMID: 21255590. Epub 2011/01/25. eng.CrossRefPubMedGoogle Scholar
  40. 40.
    Schmahmann JD. Vascular syndromes of the thalamus. Stroke. 2003;34(9):2264–78. PubMed PMID: 12933968. Epub 2003/08/23. eng.CrossRefPubMedGoogle Scholar
  41. 41.
    Clarke S, Assal G, Bogousslavsky J, Regli F, Townsend DW, Leenders KL, et al. Pure amnesia after unilateral left polar thalamic infarct: topographic and sequential neuropsychological and metabolic (PET) correlations. J Neurol Neurosurg Psychiatry. 1994;57(1):27–34. PubMed PMID: 8301301. Epub 1994/01/01. eng.CrossRefPubMedGoogle Scholar
  42. 42.
    Schott JM, Crutch SJ, Fox NC, Warrington EK. Development of selective verbal memory impairment secondary to a left thalamic infarct: a longitudinal case study. J Neurol Neurosurg Psychiatry. 2003;74(2):255–7. PubMed PMID: 12531963. Epub 2003/01/18. eng.CrossRefPubMedGoogle Scholar
  43. 43.
    Kishiyama MM, Yonelinas AP, Kroll NE, Lazzara MM, Nolan EC, Jones EG, et al. Bilateral thalamic lesions affect recollection- and familiarity-based recognition memory judgments. Cortex. 2005;41(6):778–88. PubMed PMID: 16353367. Epub 2005/12/16. eng.CrossRefPubMedGoogle Scholar
  44. 44.
    Van der Werf YD, Scheltens P, Lindeboom J, Witter MP, Uylings HB, Jolles J. Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions. Neuropsychologia. 2003;41(10):1330–44. PubMed PMID: 12757906. Epub 2003/05/22. eng.CrossRefPubMedGoogle Scholar
  45. 45.
    Van der Werf YD, Jolles J, Witter MP, Uylings HB. Contributions of thalamic nuclei to declarative memory functioning. Cortex. 2003;39(4–5):1047–62. PubMed PMID: 14584566. Epub 2003/10/31. eng.PubMedGoogle Scholar
  46. 46.
    Carlesimo GA, Serra L, Fadda L, Cherubini A, Bozzali M, Caltagirone C. Bilateral damage to the mammillo-thalamic tract impairs recollection but not familiarity in the recognition process: a single case investigation. Neuropsychologia. 2007;45(11):2467–79. PubMed PMID: 17512561. Epub 2007/05/22. eng.CrossRefPubMedGoogle Scholar
  47. 47.
    Aggleton JP, O’Mara SM, Vann SD, Wright NF, Tsanov M, Erichsen JT. Hippocampal-anterior thalamic pathways for memory: uncovering a network of direct and indirect actions. Eur J Neurosci. 2010;31(12):2292–307. PubMed PMID: 20550571. Epub 2010/06/17. eng.CrossRefPubMedGoogle Scholar
  48. 48.
    Klein JC, Rushworth MF, Behrens TE, Mackay CE, de Crespigny AJ, D’Arceuil H, et al. Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography. Neuroimage. 2010;51(2):555–64. PubMed PMID: 20206702. Epub 2010/03/09. eng.CrossRefPubMedGoogle Scholar
  49. 49.
    Guberman A, Stuss D. The syndrome of bilateral paramedian thalamic infarction. Neurology. 1983;33(5):540–6. PubMed PMID: 6682494. Epub 1983/05/01. eng.CrossRefPubMedGoogle Scholar
  50. 50.
    Ghika-Schmid F, Bogousslavsky J. The acute behavioral syndrome of anterior thalamic infarction: a prospective study of 12 cases. Ann Neurol. 2000;48(2):220–7. PubMed PMID: 10939573. Epub 2000/08/12. eng.CrossRefPubMedGoogle Scholar
  51. 51.
    Cipolotti L, Husain M, Crinion J, Bird CM, Khan SS, Losseff N, et al. The role of the thalamus in amnesia: a tractography, high-resolution MRI and neuropsychological study. Neuropsychologia. 2008;46(11):2745–58. PubMed PMID: 18597798. Epub 2008/07/04. eng.CrossRefPubMedGoogle Scholar
  52. 52.
    Graff-Radford NR, Damasio H, Yamada T, Eslinger PJ, Damasio AR. Nonhaemorrhagic thalamic infarction. Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. Brain. 1985;108(Pt 2):485–516. PubMed PMID: 4005533. Epub 1985/06/01. eng.CrossRefPubMedGoogle Scholar
  53. 53.
    Parkin AJ, Rees JE, Hunkin NM, Rose PE. Impairment of memory following discrete thalamic infarction. Neuropsychologia. 1994;32(1):39–51. PubMed PMID: 8818153. Epub 1994/01/01. eng.CrossRefPubMedGoogle Scholar
  54. 54.
    Bogousslavsky J, Regli F, Assal G. The syndrome of unilateral tuberothalamic artery territory infarction. Stroke. 1986;17(3):434–41. PubMed PMID: 2424153. Epub 1986/05/01. eng.CrossRefPubMedGoogle Scholar
  55. 55.
    Cole M, Winkelman MD, Morris JC, Simon JE, Boyd TA. Thalamic amnesia: Korsakoff syndrome due to left thalamic infarction. J Neurol Sci. 1992;110(1–2):62–7. PubMed PMID: 1506870. Epub 1992/07/01. eng.CrossRefPubMedGoogle Scholar
  56. 56.
    Baldo JV, Delis D, Kramer J, Shimamura AP. Memory performance on the California Verbal Learning Test-II: findings from patients with focal frontal lesions. J Int Neuropsychol Soc. 2002;8(4):539–46. PubMed PMID: 12030307. Epub 2002/05/28. eng.CrossRefPubMedGoogle Scholar
  57. 57.
    Shimamura AP. Memory and the prefrontal cortex. Ann N Y Acad Sci. 1995;769:151–9. PubMed PMID: 8595022. Epub 1995/12/15. eng.CrossRefPubMedGoogle Scholar
  58. 58.
    Verfaellie M, Rapcsak SZ, Keane MM, Alexander MP. Elevated false recognition in patients with frontal lobe damage is neither a general nor a unitary phenomenon. Neuropsychology. 2004;18(1):94–103. PubMed PMID: 14744192. Epub 2004/01/28. eng.CrossRefPubMedGoogle Scholar
  59. 59.
    Shimamura AP, Janowsky JS, Squire LR. Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients. Neuropsychologia. 1990;28(8):803–13. PubMed PMID: 2247207. Epub 1990/01/01. eng.CrossRefPubMedGoogle Scholar
  60. 60.
    Kopelman MD, Stanhope N, Kingsley D. Temporal and spatial context memory in patients with focal frontal, temporal lobe, and diencephalic lesions. Neuropsychologia. 1997;35(12):1533–45. PubMed PMID: 9460723. Epub 1998/02/14. eng.CrossRefPubMedGoogle Scholar
  61. 61.
    Schnider A, Ptak R. Spontaneous confabulators fail to suppress currently irrelevant memory traces. Nat Neurosci. 1999;2(7):677–81. PubMed PMID: 10404203. Epub 1999/07/15. eng.CrossRefPubMedGoogle Scholar
  62. 62.
    Hashimoto R, Tanaka Y, Nakano I. Amnesic confabulatory syndrome after focal basal forebrain damage. Neurology. 2000;54(4):978–80. PubMed PMID: 10690998. Epub 2000/02/26. eng.CrossRefPubMedGoogle Scholar
  63. 63.
    Fischer RS, Alexander MP, D’Esposito M, Otto R. Neuropsychological and neuroanatomical correlates of confabulation. J Clin Exp Neuropsychol. 1995;17(1):20–8. PubMed PMID: 7608298. Epub 1995/02/01. eng.CrossRefPubMedGoogle Scholar
  64. 64.
    Gilboa A, Alain C, Stuss DT, Melo B, Miller S, Moscovitch M. Mechanisms of spontaneous confabulations: a strategic retrieval account. Brain. 2006;129(Pt 6):1399–414. PubMed PMID: 16638795. Epub 2006/04/28. eng.CrossRefPubMedGoogle Scholar
  65. 65.
    Wheeler MA, Stuss DT, Tulving E. Frontal lobe damage produces episodic memory impairment. J Int Neuropsychol Soc. 1995;1(6):525–36. PubMed PMID: 9375239. Epub 1995/11/01. eng.CrossRefPubMedGoogle Scholar
  66. 66.
    Wheeler MA, Stuss DT. Remembering and knowing in patients with frontal lobe injuries. Cortex. 2003;39(4–5):827–46 PMID: 14584555. Epub 2003/10/31. eng.CrossRefPubMedGoogle Scholar
  67. 67.
    Alexander MP, Stuss DT, Fansabedian N. California Verbal Learning Test: performance by patients with focal frontal and non-frontal lesions. Brain. 2003;126(Pt 6):1493–503. PubMed PMID: 12764068. Epub 2003/05/24. eng.CrossRefPubMedGoogle Scholar
  68. 68.
    Curran T, Schacter DL, Norman KA, Galluccio L. False recognition after a right frontal lobe infarction: memory for general and specific information. Neuropsychologia. 1997;35(7):1035–49. PubMed PMID: 9226663. Epub 1997/07/01. eng.CrossRefPubMedGoogle Scholar
  69. 69.
    Rapcsak SZ, Nielsen L, Littrell LD, Glisky EL, Kaszniak AW, Laguna JF. Face memory impairments in patients with frontal lobe damage. Neurology. 2001;57(7):1168–75. PubMed PMID: 11591831. Epub 2001/10/10. eng.CrossRefPubMedGoogle Scholar
  70. 70.
    Logothetis NK, Sheinberg DL. Visual object recognition. Annu Rev Neurosci. 1996;19:577–621. PubMed PMID: 8833455. Epub 1996/01/01. eng.CrossRefPubMedGoogle Scholar
  71. 71.
    Karnath HO, Ruter J, Mandler A, Himmelbach M. The anatomy of object recognition–visual form agnosia caused by medial occipitotemporal stroke. J Neurosci. 2009;29(18):5854–62. PubMed PMID: 19420252. Epub 2009/05/08. eng.CrossRefPubMedGoogle Scholar
  72. 72.
    Rossion B, Caldara R, Seghier M, Schuller AM, Lazeyras F, Mayer E. A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing. Brain. 2003;126(Pt 11):2381–95. PubMed PMID: 12876150. Epub 2003/07/24. eng.CrossRefPubMedGoogle Scholar
  73. 73.
    Barsalou LW. Simulation, situated conceptualization, and prediction. Philos Trans R Soc Lond B Biol Sci. 2009;364(1521):1281–9. PubMed PMID: 19528009. Epub 2009/06/17. eng.CrossRefPubMedGoogle Scholar
  74. 74.
    Kable JW, Lease-Spellmeyer J, Chatterjee A. Neural substrates of action event knowledge. J Cogn Neurosci. 2002;14(5):795–805. PubMed PMID: 12167263. Epub 2002/08/09. eng.CrossRefPubMedGoogle Scholar
  75. 75.
    Greenberg DL, Rubin DC. The neuropsychology of autobiographical memory. Cortex. 2003;39(4–5):687–728. PubMed PMID: 14584549. Epub 2003/10/31. eng.CrossRefPubMedGoogle Scholar
  76. 76.
    Moscovitch C, Kapur S, Kohler S, Houle S. Distinct neural correlates of visual long-term memory for spatial location and object identity: a positron emission tomography study in humans. Proc Natl Acad Sci U S A. 1995;92(9):3721–5. PubMed PMID: 7731972. Epub 1995/04/25. eng.CrossRefPubMedGoogle Scholar
  77. 77.
    Ogden JA. Visual object agnosia, prosopagnosia, achromatopsia, loss of visual imagery, and autobiographical amnesia following recovery from cortical blindness: case M.H. Neuropsychologia. 1993;31(6):571–89. PubMed PMID: 8341415. Epub 1993/06/01. eng.CrossRefPubMedGoogle Scholar
  78. 78.
    Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology. 1993;43(2):250–60. PubMed PMID: 8094895. Epub 1993/02/01. eng.CrossRefPubMedGoogle Scholar
  79. 79.
    van Asselen M, Kessels RP, Frijns CJ, Kappelle LJ, Neggers SF, Postma A. Object-location memory: a lesion-behavior mapping study in stroke patients. Brain Cogn. 2009;71(3):287–94. PubMed PMID: 19733953. Epub 2009/09/08. eng.CrossRefPubMedGoogle Scholar
  80. 80.
    Saito K, Kimura K, Minematsu K, Shiraishi A, Nakajima M. Transient global amnesia associated with an acute infarction in the retrosplenium of the corpus callosum. J Neurol Sci. 2003;210(1–2):95–7. PubMed PMID: 12736096. Epub 2003/05/09. eng.CrossRefPubMedGoogle Scholar
  81. 81.
    Kessels RP, de Haan EH, Kappelle LJ, Postma A. Selective impairments in spatial memory after ischaemic stroke. J Clin Exp Neuropsychol. 2002;24(1):115–29. PubMed PMID: 11935430. Epub 2002/04/06. eng.CrossRefPubMedGoogle Scholar
  82. 82.
    Malhotra P, Coulthard EJ, Husain M. Role of right posterior parietal cortex in maintaining attention to spatial locations over time. Brain. 2009;132(Pt 3):645–60. PubMed PMID: 19158107. Pubmed Central PMCID: 2664449. Epub 2009/01/23. eng.CrossRefPubMedGoogle Scholar
  83. 83.
    Erkinjuntti T. Vascular cognitive deterioration and stroke. Cerebrovasc Dis. 2007;24 Suppl 1:189–94. PubMed PMID: 17971655. Epub 2007/11/29. eng.CrossRefPubMedGoogle Scholar
  84. 84.
    Gorelick PB. Risk factors for vascular dementia and Alzheimer disease. Stroke. 2004;35(11 Suppl 1):2620–2. PubMed PMID: 15375299. Epub 2004/09/18. eng.CrossRefPubMedGoogle Scholar
  85. 85.
    Knopman DS. Cerebrovascular pathology in cognitive impairment: new (in)sights. Neurology. 2012. PubMed PMID: 22377812. Epub 2012/03/02. Eng.Google Scholar
  86. 86.
    Vermeer SE, Longstreth Jr WT, Koudstaal PJ. Silent brain infarcts: a systematic review. Lancet Neurol. 2007;6(7):611–9. PubMed PMID: 17582361. Epub 2007/06/22. eng.CrossRefPubMedGoogle Scholar
  87. 87.
    Reitz C, Luchsinger JA, Mayeux R. Vascular disease and cognitive impairment. Expert Rev Neurother. 2008;8(8):1171–4. PubMed PMID: 18671658. Epub 2008/08/02. eng.CrossRefPubMedGoogle Scholar
  88. 88.
    Black S, Gao F, Bilbao J. Understanding white matter disease: imaging-pathological correlations in vascular cognitive impairment. Stroke. 2009;40(3 Suppl):S48–52. PubMed PMID: 19064767. Epub 2008/12/10. eng.CrossRefPubMedGoogle Scholar
  89. 89.
    Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marie I, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 2008;57(5):680–90.CrossRefPubMedGoogle Scholar
  90. 90.
    Esiri MM, Nagy Z, Smith MZ, Barnetson L, Smith AD. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease. Lancet. 1999;354(9182):919–20. PubMed PMID: 10489957. Epub 1999/09/18. eng.CrossRefPubMedGoogle Scholar
  91. 91.
    Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277(10):813–7. PubMed PMID: 9052711. Epub 1997/03/12. eng.CrossRefPubMedGoogle Scholar
  92. 92.
    Sachdev PS, Brodaty H, Looi JC. Vascular dementia: diagnosis, management and possible prevention. Med J Aust. 1999;170(2):81–5. PubMed PMID: 10026690. Epub 1999/02/23. eng.PubMedGoogle Scholar
  93. 93.
    Looi JC, Sachdev PS. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology. 1999;53(4):670–8. PubMed PMID: 10489025. Epub 1999/09/17. eng.CrossRefPubMedGoogle Scholar
  94. 94.
    Hayden KM, Zandi PP, Lyketsos CG, Khachaturian AS, Bastian LA, Charoonruk G, et al. Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis Assoc Disord. 2006;20(2):93–100. PubMed PMID: 16772744. Epub 2006/06/15. eng.CrossRefPubMedGoogle Scholar
  95. 95.
    Leys D, Henon H, Mackowiak-Cordoliani MA, Pasquier F. Poststroke dementia. Lancet Neurol. 2005;4(11):752–9. PubMed PMID: 16239182. Epub 2005/10/22. eng.CrossRefPubMedGoogle Scholar
  96. 96.
    Pasi M, Poggesi A, Salvadori E, Pantoni L. Post-stroke dementia and cognitive impairment. Front Neurol Neurosci. 2012;30:65–9. PubMed PMID: 22377866. Epub 2012/03/02. eng.CrossRefPubMedGoogle Scholar
  97. 97.
    Cordoliani-Mackowiak MA, Henon H, Pruvo JP, Pasquier F, Leys D. Poststroke dementia: influence of hippocampal atrophy. Arch Neurol. 2003;60(4):585–90.CrossRefPubMedGoogle Scholar
  98. 98.
    Pendlebury ST. Stroke-related dementia: rates, risk factors and implications for future research. Maturitas. 2009;64(3):165–71. PubMed PMID: 19818568. Epub 2009/10/13. eng.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Rotman Research Institute, Baycrest Centre for Geriatric CareTorontoCanada
  2. 2.Department of PsychiatryUniversity of TorontoTorontoCanada
  3. 3.Department PsychologyUniversity of TorontoTorontoCanada

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