Optical measurement has been widely used for obtaining physiological and biochemical information used for intra-operative diagnosis. Optical signals such as tissue reflectance spectra and fluorescence spectra of endogenous or exogenous fluorescent molecules that provide pathological information can be used for identification of pathological lesion during surgical operation. These kinds of optical information can be mapped to the anatomical information used for surgical navigation to help surgeon’s intra-operative determination of pathological/healthy area in surgical field. This enables target therapy of the pathological area that can keep the healthy tissue intact. Appropriate use of molecular probes that serve as contrast agent for specific target is important. Since optical information provides only the information from surface layer of the tissue because penetration depth of light is limited due to tissue absorption and scattering, integration with other volumetric information obtained by three dimensional medical imaging systems such as CT and MRI is recommended to realize practical surgical navigation system.
KeywordsIschemia Adenocarcinoma Adenoma Retina NADH
- 6.Liao H et al. Surgical navigation of integral videography image overlay for open MRI-guided glioma surgery. Medical Imaging and Augmented Reality 2006 (MIAR2006), LNCS 4091, 2006, pp. 187–94.Google Scholar
- 7.Muragaki Y et al. Usefulness of intraoperative magnetic resonance imaging for glioma surgery. Acta Neurochir. 2006;98(Suppl):67–75.Google Scholar
- 19.Nakagawa A et al. Clinical implications of intraoperative infrared brain surface monitoring during superficial temporal artery–middle cerebral artery anastomosis in patients with moyamoya disease. J Neurosurg. 2009;111(6):1158–64.Google Scholar
- 23.Flower RW, Hochheimer BF. A clinical technique and apparatus for simultaneous angiography of the separate retinal and choroidal circulations. Invest Ophthalmol Vis Sci. 1973;12(4):248.Google Scholar
- 32.Ando T et al. Precise comparison of protoporphyrin IX fluorescence spectra with pathological results for brain tumor tissue identification. Brain Tumor Pathol. 2010;28:1–9.Google Scholar
- 40.Omori S et al. Robotic laser surgery with X = 2. 8 μm microlaser in neurosurgery. J Robot Mech. 2004;16:22–128.Google Scholar