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Abstract

A number of advances in recent years have significantly furthered our understanding of filovirus attachment and cellular tropism. For example, several cell-surface molecules have been identified as attachment factors with the potential to facilitate the in vivo targeting of particular cell types such as macrophages and hepatic cells. Furthermore, our knowledge of internalization and subsequent events during filovirus entry has also been widened, adding new variations to the paradigms for viral entry established for HIV and influenza. In particular, host cell factors such as endosomal proteases and the intracellular receptor Niemann-Pick C1 are now known to play a vital role in activating the membrane fusion potential of filovirus glycoproteins.

Keywords

Membrane Fusion Marburg Virus Severe Acute Respiratory Syndrome Coronavirus Viral Fusion Protein Folate Receptor Alpha 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2013

Authors and Affiliations

  • Graham Simmons
    • 1
  1. 1.Blood Systems Research Institute; Department of Laboratory MedicineUniversity of California, San FranciscoSan FranciscoUSA

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