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Entry of Influenza Virus

  • Xiangjie Sun
  • Gary R. WhittakerEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 790)

Abstract

As a major pathogen of human and certain animal species, influenza virus causes wide spread and potentially devastating disease. To initiate infection, the virus first binds to cellularreceptors comprising either -(2,3 ) or -(2,6) linked sialic acid. Recent advances in our understanding of the influenza virus receptor and viral host species involved have shed light on the molecular mechanism of how influenza virus transmits across species and adapts to a new host. Following receptor binding, influenza viruses are internalized through multiple endocytic pathways, including both clathrin- and non-clathrin-dependent routes, which have recently been visualized at single viral particle level. The viral envelope then fuses with the endosomal membrane in a low pH-dependent manner and the viral genome is released into the cytosol, followed by further transport to the nucleus where genome replication occurs.

Keywords

Influenza Virus Sialic Acid Avian Influenza Nuclear Import Highly Pathogenic Avian Influenza 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyCornell UniversityIthacaUSA

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