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Reovirus Receptors, Cell Entry, and Proapoptotic Signaling

  • Pranav Danthi
  • Geoffrey H. Holm
  • Thilo Stehle
  • Terence S. DermodyEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 790)

Abstract

Mammalian orthoreoviruses (reoviruses) are members of the Reoviridae. Reoviruses contain 10 double-stranded (ds) RNA gene segments enclosed in two concentric protein shells, called outer capsid and core. These viruses serve as a versatile experimental system for studies of viral replication events at the virus-cell interface, including engagement of cell-surface receptors, internalization and disassembly, and activation of the innate immune response, including NF-κB-dependent cellular signaling pathways. Reoviruses also provide a model system for studies of virus-induced apoptosis and organ-specific disease in vivo.

Reoviruses attach to host cells via the filamentous attachment protein, σ1. The σ1 protein of all reovirus serotypes engages junctional adhesion molecule-A (JAM-A), an integral component of intercellular tight junctions. The σ1 protein also binds to cell-surface carbohydrate, with the type of carbohydrate bound varying by serotype. Following attachment to JAM-A and carbohydrate, reovirus internalization is mediated by β1 integrins, most likely via clathrin-dependent endocytosis. In the endocytic compartment, reovirus outer-capsid protein σ3 is removed by acid-dependent cysteine proteases in most cell types. Removal of σ3 results in the exposure of a hydrophobic conformer of the viral membrane-penetration protein, μ1, which pierces the endosomal membrane and delivers transcriptionally active reovirus core particles into the cytoplasm.

Reoviruses induce apoptosis in both cultured cells and infected mice. Perturbation of reovirus disassembly using inhibitors of endosomal acidification or protease activity abrogates apoptosis. The μ1-encoding M2 gene is genetically linked to strain-specific differences in apoptosis-inducing capacity, suggesting a function for μ1 in induction of death signaling. Reovirus disassembly leads to activation of transcription factor NF-κB, which modulates apoptotic signaling in numerous types of cells. Inhibition of NF-κB nuclear translocation using either pharmacologic agents or expression of transdominant forms of IκB blocks reovirus-induced apoptosis, suggesting an essential role for NF-κB activation in the death response. Multiple effector pathway s downstream of NF-κB-directed gene expression execute reovirus-induced cell death. This chapter will focus on the mechanisms by which reovirus attachment and disassembly activate NF-κB and stimulate the cellular proapoptotic machinery.

Keywords

Sialic Acid PROAPOPTOTIC Signaling Reovirus Infection Mammalian Reovirus Reovirus Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2013

Authors and Affiliations

  • Pranav Danthi
    • 1
  • Geoffrey H. Holm
    • 2
  • Thilo Stehle
    • 3
    • 4
  • Terence S. Dermody
    • 3
    • 5
    • 6
    Email author
  1. 1.Department of BiologyIndiana UniversityBloomingtonUSA
  2. 2.Department of BiologyColgate UniversityHamiltonUSA
  3. 3.Department of PediatricsVanderbilt University School of MedicineNashvilleUSA
  4. 4.Interfakultäres Institut für BiochemieEberhard-Karls UniversitätTübingenGermany
  5. 5.Lamb Center for Pediatric ResearchVanderbilt University School of MedicineNashvilleUSA
  6. 6.Department of Pathology, Microbiology and ImmunologyVanderbilt University School of MedicineNashvilleUSA

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