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Picornavirus Entry

  • Chapter
Book cover Viral Entry into Host Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 790))

Abstract

The essential event in picornavirus entry is the delivery of the RNA genome to the cytoplasm of a target cell, where replication occurs. In the past several years progress has been made in understanding the structural changes in the virion important for uncoating and RNA release. In addition, for several viruses the endocytic mechanisms responsible for internalization have been identified, as have the cellular sites at which uncoating occurs. It has become clear that entry is not a passive process, and that viruses initiate specific signals required for entry. And we have begun to recognize that for a given virus, there may be multiple routes of entry, depending on the particular target cell and the receptors available on that cell.

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Authors and Affiliations

  1. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Division of Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Jeffrey M. Bergelson

  2. Department Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

    Carolyn B. Coyne

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  1. Jeffrey M. Bergelson
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Correspondence to Jeffrey M. Bergelson .

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Editors and Affiliations

  1. Institute for Virology, Hannover Medical School, Hannover, Germany

    Stefan Pöhlmann PhD

  2. German Primate Center, Göttingen, Germany

    Stefan Pöhlmann PhD

  3. Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA

    Graham Simmons PhD

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Bergelson, J.M., Coyne, C.B. (2013). Picornavirus Entry. In: Pöhlmann, S., Simmons, G. (eds) Viral Entry into Host Cells. Advances in Experimental Medicine and Biology, vol 790. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7651-1_2

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