Making a Confident Diagnosis of Obliterative Bronchiolitis

  • A. Whitney Brown
  • Steven D. NathanEmail author
Part of the Respiratory Medicine book series (RM, volume 8)


Bronchiolitis obliterans syndrome (BOS) is a dreaded complication of lung transplantation. Despite the fact that over 50 % of lung transplant recipients will eventually be diagnosed with BOS, it remains a challenging diagnosis to make with complete certainty. This diagnostic dilemma is a product of the inherent limitations of spirometry, the parameter upon which the diagnosis relies, as well as the many confounding diagnoses that must be considered and excluded before the diagnosis of BOS can be made. This chapter seeks to explore the diagnostic challenges surrounding BOS with the aim of establishing a diagnostic framework to assist the clinician with making a more confident diagnosis of BOS.


Bronchiolitis obliterans syndrome Chronic lung allograft dysfunction Forced expiratory volume in one second Obliterative bronchiolitis Spirometry 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Advanced Lung Disease and Lung Transplant ProgramInova Fairfax HospitalFalls ChurchUSA

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