Bronchiolitis Obliterans Syndrome in Children

  • Paul D. RobinsonEmail author
  • Paul Aurora
Part of the Respiratory Medicine book series (RM, volume 8)


Extrapolation of adult-based evidence into pediatric management decisions is often unavoidable owing to a lack of sufficiently powered, suitably designed pediatric studies. Pediatric data are emerging but are challenged by the lower numbers of lung and heart–lung transplants performed annually as compared to adult transplantation. Pediatric data are further diluted by the relatively large number of centers that perform pediatric transplants internationally. This chapter will discuss available pediatric data to illustrate the similarities that exist between pediatric and adult subjects with respect to incidence, risk factors, diagnosis, and management of bronchiolitis obliterans (BO). Although the pediatric lung transplant literature generally supports the use of data that are extrapolated from lung transplantation in adults, specific challenges also exist that are unique to the pediatric age range, and the resultant differences in approach are outlined.


Pediatric Extrapolation Lung function Diagnosis Risk factors Management 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Portex Respiratory UnitUCL Institute of Child HealthLondonUK
  2. 2.Department of Pediatric Respiratory MedicineThe Children’s Hospital at WestmeadWestmead, SydneyAustralia
  3. 3.Department of Paediatric Respiratory MedicineGreat Ormond Street Hospital for ChildrenLondonUK

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