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The Role of Autoimmunity in the Pathogenesis of Obliterative Bronchiolitis

  • Rudolf K. Braun
  • Keith C. Meyer
  • William J. BurlinghamEmail author
Chapter
Part of the Respiratory Medicine book series (RM, volume 8)

Abstract

Many risk factors and post-transplant events have been linked to the development of bronchiolitis obliterans syndrome. Evolving research suggests that the development of cell-mediated and humoral reactivity to self-antigens (collagen V, K-α1 tubulin) in the lung allograft may play a very significant role in the bronchiolar inflammation and fibrosis that lead to obliterative bronchiolitis and progressive graft dysfunction and loss. Alloimmune and autoimmune mechanisms likely work together to mediate chronic lung allograft rejection. This chapter examines the role of autoimmunity in bronchiolitis obliterans syndrome with a focus on the role of Th17 lymphocytes, IL-17, and immune regulatory mechanisms in the development and progression of obliterative bronchiolitis.

Keywords

Autoimmunity Alloimmunity Lung transplant Bronchiolitis obliterans syndrome Obliterative bronchiolitis Chronic rejection 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rudolf K. Braun
    • 1
  • Keith C. Meyer
    • 2
  • William J. Burlingham
    • 3
    Email author
  1. 1.Department of PediatricsUniversity of Wisconsin MadisonMadisonUSA
  2. 2.Department of Internal Medicine, Section of Allergy, Pulmonary and Critical Care MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  3. 3.Department of SurgeryUniversity of WisconsinMadisonUSA

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