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Pathophysiology of Hypertension in Blacks pp 214–236Cite as

(pro)Renin Processing and Secretion in Black Essential Hypertension and Other Low-Renin Syndromes

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Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Renin, it is now certain, plays an important role in a significant number of disorders, such as essential hypertension and diabetic hypertension in blacks. These disorders have been categorized along sharp renin lines: high, normal, and low renin subgroups (11,54). Renin initiates the cleavage of angiotensin I, which is subsequently converted to angiotensin II, a potent vasoconstrictor molecule that stimulates aldosterone and vasopressin secretion and salt and water retention. By initiating the cascade, renin is therefore a significant factor in the physiological manifestation of the renin—angiotensin—aldosterone system (RAAS). RAAS plays an important role in cardiovascular homeostasis and chemiosmotic (salt and water coupled to proton movement) balance, but renin secretion from the kidney is a key step in the system. There is general agreement that renin physiological inhibition (or its equivalent) provides rational therapeutic efficacy for high-renin essential hypertension (106). Calcium channel blockade has also been shown to provide satisfactory results, even in the low-renin subgroup where earlier therapeutic strategies have proven largely ineffective. In low-renin hypertension (LRH) and diabetic lowrenin hypertension (dLRH), characteristic of an increasing number of blacks, only recently has sufficient evidence been accumulated to target specific molecules controlling renin secretion at the cellular level, thereby opening the way for novel approaches to drug development. It is clear that calcium and chemiosmotic forces are central to the control of renin secretion and that the renin profiles observed in some renin disorders may reflect abnormal control at specific sites along the secretory cascade (33). This chapter surveys briefly the current state of knowledge in the low-renin subgroup, as it relates to renin and prorenin [(pro)Renin] processing, storage, and secretion. We also focus on theories of (pro)Renin secretion in an attempt to describe the sites of control (and thereby prime targets of abnormal function as evidenced by examples of lowrenin syndromes [LRS]) (27), and consider briefly the prospects and sites of action of the most successful therapeutic agents used to address LRH and dLRH.

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References

  1. Abe, K., N. Irokawa, H. Aoyagi, M. Seino, M. Yasujima, K. Ritz, T. Ito, S. Chiba, Y. Sakurai, K. Saito, T. Kusaka, Y. Otsuka, S. Miyazaki, and K. Yoshinaga. Low renin hypertension: is it a stage of essential hypertension? Tohoku J. Exp. Med. 121: 347–354, 1977.

    Article  PubMed  CAS  Google Scholar 

  2. Bailey, C. C., O. T. Bailey, and R. S. Leech. Alloxan diabetes with diabetic complications. N. Engl. J. Med. 230: 533–536, 1944.

    Article  CAS  Google Scholar 

  3. Barajas, L. The development and ultrastructure of the juxtaglomerular cell granule. J. Ultrastruct. Res. 15: 400–413, 1966.

    Article  PubMed  CAS  Google Scholar 

  4. Bartter, F. C., P. Pronoue, J. R. Gill, R. C. McCardle. Hyperplasia of the juxtaglonerular complex with hyperaldosteronism and hypokalemic alkalosis: a new syndrome. Am. J. Med. 33: 811–828, 1962.

    Article  PubMed  CAS  Google Scholar 

  5. Beretta-Picesli, C., P. Weidmann, W. Ziegler, Z. Gluck, and G. Kensch. Plasma catecholamines and renin in diabetes mellitus: relationships with posture, age, sodium, and blood pressure. Klin. Wochenschr. 57: 681–691, 1979.

    Article  Google Scholar 

  6. Bouhnik, J., F. X. Galen, E. C. Clauser, J. Menard, and P. Corvol. The renin-angiotensin system in thyroidectomized rats. Endocrinology 108: 647–650, 1981.

    Article  PubMed  CAS  Google Scholar 

  7. Brunner, H. R., J. Nussberger, and B. Waeber. Responsiveness of renin secretion: a key mechanism in the maintenance of blood pressure. J. Hypertens. 4 (Suppl. 4): S89 - S94, 1986.

    CAS  Google Scholar 

  8. Burden, A. C., and H. Thurston. Plasma renin activity in diabetes mellitus. Clin. Sci. 56: 255–259, 1979.

    PubMed  CAS  Google Scholar 

  9. Channick, B. J., E. V. Adlin, A. D. Marks. Suppressed plasma renin activity in hypertension. Arch. Intern. Med. 123: 131–140, 1969.

    Article  PubMed  CAS  Google Scholar 

  10. Chatel, R. D., P. Weidmann, J. Flammer, W. H. Ziegler, C. Beretta-Piccoli, W. Vetter, and F. C. Reubi. Sodium, renin, aldosterone, catecholamines, and blood pressure in diabetes mellitus. Kidney Int. 12: 412–421, 1977.

    Article  PubMed  Google Scholar 

  11. Christlieb, A. R. Diabetes and hypertensive vascular disease. Am. J. Cardiol. 32: 59 2606, 1976.

    Google Scholar 

  12. Christlieb, A. R. Renin-angiotensin-aldosterone system in diabetes mellitus. Diabetes 25 (Suppl. 2): 820–825, 1976.

    PubMed  CAS  Google Scholar 

  13. Christlieb, A. R. Renin, angiotensin, and norepinephrine in alloxan diabetes. Diabetes 23: 962–970, 1974.

    PubMed  CAS  Google Scholar 

  14. Christlieb, A. R., A. Kaldany, J. A. D’Elia. Plasma renin activity and hypertension in diabetes mellitus. Diabetes 25: 969–974, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Christlieb, A. R., A. Kaldany, J. A. D’Elia, and G. H. Williams. Aldosterone responsiveness in patients with diabetes mellitus. Diabetes 27: 732–737, 1978.

    Article  PubMed  CAS  Google Scholar 

  16. Chrysant, S. G., K. Danisa, D. C. Kern, B. L. Dillard, W. J. Smith, and E. D. Frohlich. Racial differences in pressure, volume and renin interrelationships in essential hypertension. Hypertension 1: 136–141, 1979.

    Article  PubMed  CAS  Google Scholar 

  17. Cohen, A. J., P. Laurens, and J. C. S. Fray. Suppression of renin secretion by insulin: dependence on extracellular calcium. Am. J. Physiol 245 (Endocrinol Metab. 8): E531 - E534, 1983.

    Google Scholar 

  18. Cohen, A. J., K. McCarthy, R. R. Rossetti. Renin secretion by the spontaneously diabetic rat. Diabetes 35: 341–346, 1986.

    Article  PubMed  CAS  Google Scholar 

  19. Cooper, R. S., and J. L. Borke. Intracellular ions and hypertension in blacks. In: Pathophysiology of Hypertension in Blacks, edited by J. C. S. Fray and J. G. Douglas. Oxford University Press, New York, 1992.

    Google Scholar 

  20. Deleiva, A., A. R. Christlieb, J. C. Melby, C. A. Graham, R. P. Day, J. A. Luetscher, and R. G. Zager. Big renin and biosynthetic defect of aldosterone in diabetes mellitus. N. Engl. J. Med. 295: 639–643, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Derky, F. H. M., G. J. Wenting, A. J. ManI’TVeld, R. P. Verhoeven, and M. A. D. H. Schalekamp. Evidence for activation of circulating inactive renin by the human kidney. Clin. Sci. 56: 115–120, 1979.

    Google Scholar 

  22. Dunn, M. J., and R. L. Tannen. Low-renin hypertension. Kidney Int. 5: 317–325, 1974.

    Article  PubMed  CAS  Google Scholar 

  23. Fagard, R., A. Amery, T. Reybrouck, P. Lijnen, L. Billiet, and J. V. Jossens. Plasma renin levels and systemic haemodynamics in essential hypertension. Clin. Sci. Molec. Med. 52: 591–597, 1977.

    CAS  Google Scholar 

  24. Franken, A. A. M., F. H. M. Derky, A. J. ManI’tVeld, W. C. J. Hop, G. H. Rens, E. Peperkamp, P. T. V. M. Dejohn, and M. A. D. H. Schalekamp. High plasma prorenin in diabetes mellitus and its correlation with some complications. J. Clin. Endocrinol. Metab. 71: 1008–1015, 1990.

    Article  PubMed  CAS  Google Scholar 

  25. Fray, J. C. S. Mechanism of increased renin release during sodium deprivation. Am. J. Physiol. 234 (Renal Fluid Electrolyte Physiol. 4): F376 - F380, 1978.

    Google Scholar 

  26. Fray, J. C. S. Stimulus-secretion coupling of renin: role of hemodynamic and other factors. Circ. Res. 47: 485–492, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. Fray, J. C. S. Regulation of renin secretion by calcium and chemiosmotic forces: (patho) physiological considerations. Biochim. Biophys. Acta 1097: 243–262, 1991.

    Article  PubMed  CAS  Google Scholar 

  28. Fray, J. C. S. Subcellular dysregulation of renin and prorenin expression in black essential and diabetic hypertensives. Ethnicity Dis. 2: 142–157, 1992.

    CAS  Google Scholar 

  29. Fray, J. C. S., and D. J. Lush. Stretch receptor hypothesis for renin secretion: the role of calcium. J. Hypertens. 2 (Suppl. 1): 19–23, 1984.

    Article  CAS  Google Scholar 

  30. Fray, J. C. S., D. J. Lush, C. S. Park. Interrelationship of blood flow, juxtaglomerular cells, and hypertension: role of physical equilibrium and Ca. Am. J. Physiol. 251 (Regulatory Fluid Electrolyte Physiol. 20): R643 - R662, 1986.

    Google Scholar 

  31. Fray, J. C. S., and P. V. H. Mayer. Decreased plasma refill activity and renin release in rats with phaeochromocytoma. Clin. Sci. Molec. Med. 53: 447–452, 1977.

    CAS  Google Scholar 

  32. Fray, J. C. S., C. S. Park, and A. N. D. Valentine. Calcium and the control of renin secretion. Endocr. Rev. 8: 53–93, 1987.

    Article  PubMed  CAS  Google Scholar 

  33. Fray, J. C. S., and S. M. Russo. Mechanism for low renin in blacks: studies in hypophysectomised rat model. J. Hum. Hypertens. 4: 160–162, 1990.

    PubMed  CAS  Google Scholar 

  34. Ginesi, L. M., K. A. Munday, and A. R. Noble. Secretion control for active and inactive renin: effects of calcium and potassium on rabbit kidney cortex slices. J. Physiol. 344: 453–463, 1983.

    PubMed  CAS  Google Scholar 

  35. Gossain, V. V., E. E. Werk, L. J. Sholiton, L. Srivastava, and H. C. Knowles. Plasma renin activity in juvenile diabetes mellitus and effect of diazoxide. Diabetes 28: 833–835, 1975.

    Article  Google Scholar 

  36. Grim, C. E., F. C. Luft, N. S. Fineberg, and M. H. Weinberger. Responses to volume expansion and contraction in categorized hypertensive and normotensive man. Hypertension 1: 476–485, 1979.

    Article  PubMed  CAS  Google Scholar 

  37. Grim, C. E., and T. W. Wilson. Salt, slavery and survival: physiological principles underlying the evolutionary hypothesis of salt sensitive hypertension in Western Hemisphere blacks. In: Pathophysiology of Hypertension in Blacks, edited by J. C. S. Fray and J. G. Douglas. Oxford University Press, New York, 1992.

    Google Scholar 

  38. Gross, F., A. J. Vander, R. D. Bunag, and G. M. C. Masson. Renin content of kidneys. In: Renal Hypertension, edited by I. E. Page and J. W. McCubbin. Year Book Publishers, Chicago, 1968, pp. 118–133.

    Google Scholar 

  39. Haddy, F. J. Sodium-potassium pump in low-renin hypertension. Ann. Intern. Med. 93 (part 2): 781–784, 1983.

    Google Scholar 

  40. Helmer, O. M. The renin-angiotensin system and its relation to hypertension. Progr. Cardiovasc. Dis. 8: 117–128, 1965.

    Article  CAS  Google Scholar 

  41. Holland, O. B., C. Gomez-Sanchez, C. Fairchild, and N. M. Kaplan. Role of renin classification for diuretic treatment of black hypertensive patients. Arch. Intern. Med. 139: 1365–1370, 1979.

    Article  PubMed  CAS  Google Scholar 

  42. Hsueh, W. A. Potential effects of renin activation on the regulation of renin production. Am. J. Physiol. 247 (Renal Fluid Electrolyte Physiol. 16): F205 - F212, 1984.

    Google Scholar 

  43. Hsueh, W. A., E. J. Carlson, and V. J. Dzau. Characterization of inactive renin from human kidney and plasma. J. Clin. Invest. 71: 506–517, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Ikemoto, F., K. Takaori, H. Iwao, and K. Yamamoto. Intrarenal localization of renin binding substance in rats. Life Sci. 31: 1011–1016, 1982.

    Article  PubMed  CAS  Google Scholar 

  45. Inoue, H., K. Fukui, S. Takahashi, and Y. Miyake. Molecular cloning and sequence analysis of a CDNA encoding a procine kidney renin-binding protein. J. Biol. Chem. 265: 6556–6561, 1990.

    PubMed  CAS  Google Scholar 

  46. Itoh, S., M. Tanaka, F. Ikemoto, K. Yamamoto, N. Morita, and K. Okamoto. Renal highmolecular-weight renin: unusual formation in the aged stroke-prone spontaneously hypertensive rats. Renal Physiol. 9: 177–186, 1986.

    PubMed  CAS  Google Scholar 

  47. Jose, A., J. R. Crout, and N. M. Kaplan. Suppressed plasma renin activity in essential hypertension. Roles of plasma volume, blood pressure, and sympathetic nervous system. Ann. Intern. Med. 72: 9–16, 1970.

    CAS  Google Scholar 

  48. Katayama, S., and J. B. Lee. Hypertension in experimental diabetes mellitus: renin-prostaglandin interaction. Hypertension 7: 554–561, 1985.

    Article  PubMed  CAS  Google Scholar 

  49. Kelly, R. B. Pathways of protein secretion in eukaryotes. Science 230: 25–32, 1985.

    Article  PubMed  CAS  Google Scholar 

  50. Kikkawa, R., E. Kitamura, Y. Fujiwara, M. Haneda, and Y. Shigeta. Biphasic alteration of renin-angiotensin-aldosterone system in streptozotocin-diabetic rats. Renal Physiol. 9: 187–192, 1986.

    PubMed  CAS  Google Scholar 

  51. Kotchen, T. A., W. J. Welch, J. N. Lorenz, and C. E. Ott. Renal tubular chloride and refill release. J. Lab. Clin. Med. 110: 533–540, 1987.

    PubMed  CAS  Google Scholar 

  52. Kurtz, A. Cellular control of renin secretion. Rey. Physiol. Biochem. Pharmacol. 113: 140, 1989.

    Google Scholar 

  53. Kurtz, A., and R. Penner. Angiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells. Proc. Natl. Acad. Sci. U.S.A. 86: 3423–3427, 1989.

    Article  PubMed  CAS  Google Scholar 

  54. Laragh, J. H. Vasoconstriction-volume analysis for understanding and treating hypertension: the use of renin and aldosterone profiles. Am. J. Med. 55: 261–274, 1973.

    Article  PubMed  CAS  Google Scholar 

  55. Levy, S. B., L. B. Talner, M. N. Coel, R. Holle, and R. A. Stone. Renal vasculature in essential hypertension: racial differences. Ann. Intern. Med. 88: 12–16, 1978.

    Article  PubMed  CAS  Google Scholar 

  56. Lilley, J. J., L. Hsu, and R. A. Stone. Racial disparity of plasma volume in hypertensive man. Ann. Intern. Med. 84: 707–708, 1976.

    CAS  Google Scholar 

  57. Lowder, S. C., P. Hamet, and G. W. Liddle. Contrasting effects of hypoglycemia on plasma renin activity and cyclic adenosin 3’,5’-monophosphate (cyclic AMP) in low renin and normal refill essential hypertension. Circ. Res. 38: 105–108, 1976.

    Article  PubMed  CAS  Google Scholar 

  58. Mitas, J. A., R. Holle, S. B. Levey, and R. A. Stone. Racial analysis of the volume-renin relationship in human hypertension. Arch. Intern. Med. 139: 157–160, 1979.

    Article  PubMed  CAS  Google Scholar 

  59. Morris, B. J. New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated. Clin. Sci. 71: 345–355, 1986.

    Google Scholar 

  60. Murakami, K., S. Chino, S. Hirose, and J. Higaki. Specificity and localization of reninbinding protein(s). Biomed. Res. 1: 476–481, 1980.

    CAS  Google Scholar 

  61. Nakamaru, M., T. Ogihara, J. Higaki, K. Masuo, H. Ikegami, K. Shima, and Y. Kumahara. Plasma inactive renin in diabetic patients with neuropathy: a role for the sympathetic nervous system in the conversion in vivo of inactive renin. Acta Endocrinol. 104: 216221, 1983.

    Google Scholar 

  62. Nakamura, R., T. Saruta, K. Yamagami, I Saito, K. Kondo, S. Matsuki. Renin and the juxtaglomerular apparatus in diabetic nephropathy. J. Am Geriatr. Soc. 26: 17–21, 1978.

    PubMed  CAS  Google Scholar 

  63. Nakane, H., Y. Nakane, P. Corvol, and J. Menard. Sodium balance and renin regulation in rats: role of intrinsic renal mechanisms. Kidney Int. 17: 607–614, 1980.

    Article  PubMed  CAS  Google Scholar 

  64. New, M. I. The role of steroid hormones in the development of low-renin hypertension in childhood. NHLBI Workshop on Juvenile Hypertension, May, pp. 283–304, 1983.

    Google Scholar 

  65. Nishimura, K., F. Alhenc-Gelas, A. White, and E. G. Erdos. Activation of membrane-bound kallikrein and renin in the kidney. Proc. Natl. Acad. Sci. U.S.A. 77: 4975–4978, 1980.

    Article  PubMed  CAS  Google Scholar 

  66. Nishimura, K., P. Ward, and E. G. Erdos. Kallikrein and renin in the membrane fractions of the rat kidney. Hypertension 2: 538–545, 1980.

    Article  PubMed  CAS  Google Scholar 

  67. Nugent, C. A. Varieties of low renin hypertension. Milit. Med. 141: 519–522, 1977.

    Google Scholar 

  68. Ogawa, K., M. Matsunaga, H. Nagai, A. Hara, C. H. Pak, and C. Kawai. Effects of enalapril maleate on plasma level of inactive renin in renovascular hypertension. Clin. Exp. Hypertens. [A] A7: 995–1005, 1985.

    Article  CAS  Google Scholar 

  69. Ogawa, K., C. Nagai, C. H. Pak, C. Kawai, M. Matsunaga, and A. Hara. Studies on the active and inactive renin in reovascular hypertension. Clin. Exp. Hypertens. [A] A6: 1641–1651, 1984.

    Article  CAS  Google Scholar 

  70. Palade, G. Intracellular aspects of the process of protein synthesis. Science 189: 347–358, 1975.

    Article  PubMed  CAS  Google Scholar 

  71. Park, C. S., P. S. Doh, R. E. Carraway, G. C. Chung, J. C. S. Fray, and T. B. Miller. Stimulation of renin secretion by ethacrymc acid is independent of Na -K -2C1- cotransport. Am. J. Physiol. 259: (Renal Fluid Electrolyte Physiol. 28): F539 - F544, 1990.

    Google Scholar 

  72. Park, C. S., T. W. Honeyman, E. S. Chung, J. S. Lee, D. H. Sigmon, and J. C. S. Fray. Involvement of calmodulin in mediating inhibitory action of intracellular Cat+ on renin secretion. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20): F1055 - F1062, 1986.

    Google Scholar 

  73. Pedrinelli, R., A. Clerico, L. Graziadei, S. Teddei, M. D. Chicca, and A. Saluetti. Lack of evidence for NaK-ATPase inhibitor as a cause of low renin human hypertension. J. Hypertens. 4 (Suppl. 6): 340–342, 1986.

    Google Scholar 

  74. Pedrinelli, R., S. Taddei, L. Graziadei, and A. Salvetti. Vascular responses to ouabain and norepinephrine in low and normal renin hypertension. Hypertension 8: 786–792, 1986.

    Article  PubMed  CAS  Google Scholar 

  75. Perez, G. O., L. Lespier, J. Jacobi, J. R. Oster, F. H. Katz, C. A. Vaamonde, and L. M. Fishman. Hyporeninemia and hypoadosteronism in diabetes mellitus. Arch. Intern. Med. 137: 825–855, 1977.

    Google Scholar 

  76. Pinet, F., J. Mizrahi, I. Laboulandine, J. Menard, and P. Corvol. Regulation of prorenin secretion in cultured human transfected juxtaglomerular cells. J. Clin. Invest. 80: 724–731, 1987.

    Article  PubMed  CAS  Google Scholar 

  77. Pratt, R. E., J. E. Carleton, J. P. Richie, C. Heusser, and V. J. Dzau Human renin biosynthesis and secretion in normal and ischemic kidneys. Proc. Natl. Acad. Sci. U.S.A. 84: 7837–7840, 1987.

    Article  PubMed  CAS  Google Scholar 

  78. Pratt, J. H., C. A. Parkinson, M. H. Weinberger, and W. C. Duckworth. Decreases in renin and aldosterone secretion in alloxan diabetes: an effect of insulin deficiency. Endocrinology 116: 1712–1716, 1985.

    Article  PubMed  CAS  Google Scholar 

  79. Purdon, A. D., A. Y. Loh, and D. H. Osmond. Renin substrate (angiotensinogen) preparations in the determination of prorenin and renin: evidence for extrarenal plasma prorenin and its renal “convertase.” Can. J. Physiol. Pharmacol. 65: 2319–2328, 1987.

    Article  PubMed  CAS  Google Scholar 

  80. Rapp J. P., and S.-M. Wang. Genetic hypertension: classical and molecular genetic concepts as applied to the renin gene. In: Hypertension, edited by J. H. Laragh and B. M. Brenner. Raven Press, New York, 1990, pp. 955–964.

    Google Scholar 

  81. Resnick, L. M., and J. H. Laragh. Renin, calcium metabolism and the pathophysiologic basis of antihypertensive therapy. Am. J. Cardiol. 56: 68H - 74H, 1985.

    Article  PubMed  CAS  Google Scholar 

  82. Richards, H. K., D. J. Lush, A. R. Noble, and K. A. Munday. Inactive renin in rabbit plasma: effect of furosemide. Clin. Sci. 60: 393–398, 1981.

    PubMed  CAS  Google Scholar 

  83. Rouiller, C., and L. Orci. The structure of the juxtaglomerular complex. In: The Kidney, Morphology, Biochemistry, Physiology, Vol. 4, edited by C. Rouiller and A. F. Muller. Academic Press, New York, 1971, pp. 1–80.

    Google Scholar 

  84. Sadoff, L. Neprotoxicity of streptozotocin. Cancer Chemother. 54: 457–459, 1970.

    CAS  Google Scholar 

  85. Sagnella, G. A., P. R. B. Caldwell, and W. S. Peart. Subcellular distribution of low-and high-molecular-weight renin and its relation to a renin inhibitor in pig renal cortex. Clin. Sci. 59: 337–345, 1980.

    PubMed  CAS  Google Scholar 

  86. Sakamoto, W., K. Yoshikawa, A. Yokoyama, M. Kohri, H. Handa, S. Ueham, A. Hirayama, and H. Izumi Glandular kallikrein, renin and tonin in tissues of diabetic and hypertensive rats. J. Clin. Chem. Clin. Biochem. 24: 437–440, 1986.

    PubMed  CAS  Google Scholar 

  87. Saunders, E. Hypertension in blacks. Med. Clin. North Am. 71: 1013–1029, 1987.

    PubMed  CAS  Google Scholar 

  88. Schalekamp, M. A., M. Lebel, D. G. Beevers, R. Fraser, G. Kolster, and W. H. Birkenhager. Body fluid-volume in low-renin hypertension. Lancet 1: 310–311, 1974.

    Article  Google Scholar 

  89. Schalekamp, M. A. D. H., M. P. A. Schalekamp-Kuyken, and W. H. Birkenhager. Abnormal renal haemodynamics and renin suppression in hypertensive patients. Clin. Sci. 38: 101–110, 1970.

    PubMed  CAS  Google Scholar 

  90. Sealey, J. E., S. A. Atlas, and J. H. Laragh. Prorenin and other large molecular weight forms of renin. Endocr. Rev. 1: 365–391, 1980.

    Article  PubMed  CAS  Google Scholar 

  91. Sealey, J. E., and J. H. Laragh. Searching out low renin patients: limitations of some commonly used methods. Am. J. Med. 55: 303–313, 1973.

    Article  PubMed  CAS  Google Scholar 

  92. Sigmon, D. H., and J. C. S. Fray. Chemiosmotic control of renin release from isolated renin granules of rat kidneys. J. Physiol. (Lond.) 436: 237–256, 1991.

    CAS  Google Scholar 

  93. Simon, C. D., T. W. Honeyman, and J. C. S. Fray. Renin-angiotensin system in hypophysectomized rats. I. Control of blood pressure. Am. J. Physiol. 246 (Endocrinol. Metab. 10) E84 — E88, 1984.

    CAS  Google Scholar 

  94. Simon, S. M., and G. Blobel. A protein-conducting channel in the endoplasmic reticulum. Cell 65: 371–380, 1991.

    Article  PubMed  CAS  Google Scholar 

  95. Skott, O. Do osmotic forces play a role in renin secretion? Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol 24) Fl—F10,1988.

    Google Scholar 

  96. Skott, O., and R. Taugner. Effects of extracellular osmolality on renin release and on the ultrastructure of the juxtaglomerular epitheloid cell granules. Cell Tissue Res. 249: 325–329, 1987.

    Article  PubMed  CAS  Google Scholar 

  97. Sommer, S. C., and J. Melamed. Renal pathology of essential hypertension. Am. J. Hypertens. 3: 583–587, 1990.

    Google Scholar 

  98. Sullivan, P. A., M. Kelleher, M. Twomey, and M. Dineen. Effects of converting enzyme inhibition on blood pressure, plasma renin activity (PRA) and plasma aldosterone in hypertensive diabetics compared to patients with essential hypertension. J. Hyper-tens. 3: 359–363, 1985.

    Article  CAS  Google Scholar 

  99. Swales, J. D. Low-renin hypertension: nephrosclerosis? Lancet 2: 75–77, 1975.

    Article  Google Scholar 

  100. Thurston, H., and J. D. Swales. Low renin hypertension: a distinct entity. Lancet 2: 930932, 1976.

    Google Scholar 

  101. Tuek, M. L., M. P. Sambhi, and L. Levin. Hyporeninemic hypoaldosteronism in diabetes mellitus: studies of the autonomic nervous system’s control of renin release. Diabetes 28: 237–241, 1979.

    Google Scholar 

  102. Ueno, N., H. Miyazaki, S. Hirose, and K. Murakami. A 56,000-dalton renin-binding protein in hog kidney is an endogenous renin-inhibitor. J. Biol. Chem. 256: 12023–12027, 1981.

    CAS  Google Scholar 

  103. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Urinary and serum electrolytes in untreated black and white hypertensives. J. Chronic Dis. 40: 839–847, 1987.

    Article  Google Scholar 

  104. Vlahos, C. J., J. D. Walls, D. T. Berg, and B. W. Grinnell. The purification and characterization of recombinant human renin expressed in the human kidney cell line 293. Biochem. Biophys. Res. Comm. 171: 375–383, 1990.

    Article  PubMed  CAS  Google Scholar 

  105. Wilson, D. M., and J. A. Luetscher. Plasma prorenin activity and complications in children with insulin-dependent diabetes mellitus. N. Engl. J. Med. 323: 1101–1106, 1990.

    Article  PubMed  CAS  Google Scholar 

  106. Wright, J. T., and J. G. Douglas. Drug therapy in black hypertensives. In: Pathophysiology of Hypertension in Blacks, edited by J. C. S. Fray and J. G. Douglas. Oxford University Press, New York, 1992.

    Google Scholar 

  107. Yamamoto, K., and F. Ikemoto. High molecular-weight renin and renin-binding protein. Trends Pharmacol. Sci. 4: 381–383, 1983.

    CAS  Google Scholar 

  108. Zidek, W., C. Karoff, H. Losse, and H. Vetter. Weight reduction and salt restriction in hypertension: effects on blood pressure and intracellular electrolytes. Klin. Wochenschr. 64: 1183–1185, 1986.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. C. S. Fray
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Editors and Affiliations

  1. Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

    John C. S. Fray

  2. Division of Endocrinology and Hypertension, Case Western Reserve University, Cleveland, Ohio, USA

    Janice G. Douglas

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© 1993 American Physiological Society

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Fray, J.C.S. (1993). (pro)Renin Processing and Secretion in Black Essential Hypertension and Other Low-Renin Syndromes. In: Fray, J.C.S., Douglas, J.G. (eds) Pathophysiology of Hypertension in Blacks. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7577-4_10

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  • DOI: https://doi.org/10.1007/978-1-4614-7577-4_10

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7577-4

  • eBook Packages: Springer Book Archive

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