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Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?

  • Wolfgang Jelkmann
  • Horst Pagel
  • Christoph Weiss
Part of the Clinical Physiology Series book series (CLINPHY)

Abstract

The glycoprotein hormone erythropoietin (Epo) is an obligatory growth and differentiation factor for the erythrocytic progenitors. The plasma level of Epo in the human is about 5 to 25 mU/m1 under normoxic conditions. Tissue hypoxia is a major stimulus for erythropoiesis. The plasma level of Epo may increase to 1000 mU/ml or more after the induction of anemia or hypoxic hypoxia (12, 20, 31).

Keywords

Renal Artery Patent Ductus Arteriosus Renal Blood Flow Renal Artery Stenosis Hypobaric Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Beru, N., J. Mcdonald, C. Lacombe, and E. Goldwasser: Expression of the erythropoietin gene. Mol. Cell. Biol. 6: 2571–2575, 1986.PubMedGoogle Scholar
  2. 2.
    Bondurant, M. C., and M. J. Koury: Anemia induces accumulation of erythropoietin mRna in the kidney and liver. Mol. Cell. Biol. 6: 2731–2733, 1986.PubMedGoogle Scholar
  3. 3.
    Bourgoignie, J. J., N. I. Gallagher, H. M. Perry, L. Kurz, M. A. Warnecke, and R. M. Donati: Renin and erythropoietin in normotensive and in hypertensive patients. J. Lab. Clin. Med. 71: 523–536, 1968.PubMedGoogle Scholar
  4. 4.
    Caro, J., J. Hickey, and A. J. Erslev: Erythropoietin production by an established kidney proximal tubule cell line (Llcpk,). Exp. Hematol. 12: 357, 1984.Google Scholar
  5. 5.
    Cooper, G. W., and M. R. Nocenti: Unilateral renal ischemia and erythropoietin. Proc. Soc. Exp. Biol. Med. 108: 546–549, 1961.Google Scholar
  6. 6.
    Erslev, A.: J. In vitro production of erythropoietin by kidneys perfused with a serum-free solution. Blood 44:77–85, 1974.Google Scholar
  7. 7.
    Erslev, A. J., J. Caro, And A. Besarab: Why the kidney? Nephron 41: 213–216, 1985.CrossRefPubMedGoogle Scholar
  8. 8.
    Erslev, A. J., J. Caro, E. Kansu, and R. Silver: Renal and extrarenal erythropoietin production in anaemic rats. Br. J. Haematol. 45: 65–72, 1980.CrossRefPubMedGoogle Scholar
  9. 9.
    Erslev, A. J., R. W. Solit, R. C. Camishion, S. Amsel, J. Ilda, and W. F. Ballinger: II. Erythropoietin in vitro. Iii. Perfusion of a lung-kidney preparation. Am. J. Physiol. 208: 1153–1170, 1965.PubMedGoogle Scholar
  10. 10.
    Eschbach, J. W., J. C. Egrie, M. R. Downing, J. K. Browne, and J. W. Adamson: Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N. Engl. J. Med. 316: 73–78, 1987.CrossRefPubMedGoogle Scholar
  11. 11.
    Fink, G. D., and J. W. Fisher: Role of the sympathetic nervous system in the control of erythropoietin production. In: Kidney Hormones, vol. H. Erythropoietin, ed. J. W. Fisher. New York: Academic Press, 1977, pp. 387–413.Google Scholar
  12. 12.
    Fisher, J. W. Control of erythropoietin production. Proc. Soc. Exp. Biol. Med. 173: 289–305, 1983.Google Scholar
  13. 13.
    Fisher, J. W., and B. J. Birdwell: The production of an erythropoietic factor by the in situ perfused kidney. Acta Haematol. 26: 224–232, 1961.CrossRefPubMedGoogle Scholar
  14. 14.
    Fisher, J. W., D. B. Knight, and C. Couch: Influence of several diuretic drugs on erythropoietin formation. J. Pharmacol. Exp. Ther. 141: 113–121, 1963.PubMedGoogle Scholar
  15. 15.
    Fisher, J. W., and J. W. Langston: The influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney. Blood 29: 114–125, 1967.PubMedGoogle Scholar
  16. 16.
    Fisher, J. W., and J. W. Langston: Effects of testosterone, cobalt and hypoxia on erythropoietin production in the isolated perfused dog kidney. Ann. N.Y. Acad. Sci. 149: 7587, 1968.Google Scholar
  17. 17.
    Fisher, J. W., and A. I. Samuels: Relationship between renal blood flow and erythropoietin production in dogs. Proc. Soc. Exp. Biol. Med. 125: 482–485, 1967.PubMedGoogle Scholar
  18. 18.
    Fisher, J. W., R. Schofield, and D. D. Porteous: Effects of renal hypoxia on erythropoietin production. Br. J. Haematol. 11: 382–388, 1965.CrossRefPubMedGoogle Scholar
  19. 19.
    Foley, J. W., D. M. Gross, P. K. Nelson, and J. W. Fisher: The effects of arachidonic acid on erythropoietin production in exhypoxic polycythemic mice and the isolated perfused canine kidney. J. Pharmacol. Exp. Ther. 207: 402–409, 1978.PubMedGoogle Scholar
  20. 20.
    Fried, W: Erythropoietin and the kidney. Nephron 15: 327–349, 1975.CrossRefPubMedGoogle Scholar
  21. 21.
    Fried, W., J. Barone-Varelas, and M. Berman: Detection of high erythropoietin titers in renal extracts of hypoxic rats. J. Lab. Clin. Med. 97: 82–86, 1981.Google Scholar
  22. 22.
    Goldberg, M. A., S. P. Dunning, and H. F. Bunn: Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heure protein. Science 242: 1412–1415, 1988.CrossRefPubMedGoogle Scholar
  23. 23.
    Goldberg, M. A., G. A. Glass, J. M. Cunningham, and H. F. Bunn: The regulated expression of erythropoietin by two human hepatoma cell lines. Proc. Natl. Acad. Sci. (Usa) 84: 7972–7976, 1987.CrossRefGoogle Scholar
  24. 24.
    Gross, D. M., V. M. Mujovic, W. Jubiz, and J. W. Fisher: Enhanced erythropoietin and prostaglandin E production in the dog following renal artery constriction. Proc. Soc. Exp. Biol. Med. 151: 498–501, 1976.Google Scholar
  25. 25.
    Grutzmacher, P., and W. Schoeppe: Renal artery stenosis and renal polyglobulia. In: Erythropoietin, ed. W. Jelkmann and A. J. Gross. Heidelberg, Berlin, New York: Springer-Verlag, 1989 (in press).Google Scholar
  26. 26.
    Halvorsen, S: The central nervous system in regulation of erythropoiesis. Acta Haematol. 35: 65–79, 1966.CrossRefPubMedGoogle Scholar
  27. 27.
    Halvorsen, S., B. L. Roh, and J. W. Fisher: Erythropoietin production in nephrectomized and hypophysectomized animals. Am. J. Physiol. 215: 349–352, 1968.PubMedGoogle Scholar
  28. 28.
    Hudgson, P., J. M. S. Pearce, and W. K. Yeates: Renal artery stenosis with hypertension and high haematocrit. Br. Med. J. 1: 18–21, 1967.CrossRefPubMedGoogle Scholar
  29. 29.
    Jacobson, L. O., E. Goldwassesr, W. Fried, and L. Plzak: Role of the kidney in erythropoiesis. Nature 179: 633–634, 1957.CrossRefPubMedGoogle Scholar
  30. 30.
    Jeklmann, W: Temporal pattern of erythropoietin titers in kidney tissue during hypoxic hypoxia. Pflügers Arch. 393: 88–91, 1982.CrossRefGoogle Scholar
  31. 31.
    Jelkmann, W: Renal erythropoietin: properties and production. Rev. Physiol. Biochem. Pharmacol. 104: 139–215, 1986.CrossRefPubMedGoogle Scholar
  32. 32.
    Jelkmann, W., and C. Bauer: Demonstration of high levels of erythropoietin in rat kidneys following hypoxic hypoxia. Pflügers Arch. 392: 34–39, 1981.CrossRefPubMedGoogle Scholar
  33. 33.
    Jeklmann, W., J. Brookins, and J. W. Fisher: Indomethacin blockade of albuterol-induced erythropoietin production in isolated perfused dog kidneys. Proc. Soc. Exp. Biol. Med. 162: 65–70, 1979.Google Scholar
  34. 34.
    Jelkmann, W., A. Kurtz, and C. Bauer: In vitro production of erythropoietin. In: Kidney Hormones, ed. J. W. Fisher. London, New York, San Francisco: Academic Press, 1986, pp. 559–583.Google Scholar
  35. 35.
    Jelkmann, W., N. Marienhoff, S. Giesselmann, and L. Busch: Lowered plasma erythropoietin in hypoxic rats with kidney tubule lesions. Blut 57: 317–321, 1988.CrossRefPubMedGoogle Scholar
  36. 36.
    Kill, F.: Blood flow and oxygen utilization by the kidney. In: Kidney Hormones, ed. J. W. Fisher. London, New York: Academic Press, 1971, pp. 1–30.Google Scholar
  37. 37.
    Koury, S. T., M. C. Bondurant, and M. J. Koury: Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 71: 524–527, 1988.PubMedGoogle Scholar
  38. 38.
    Kuratowska, Z., B. Lewartowski, and E. Michalak: Studies on the production of erythropoietin by isolated perfused organs. Blood 18: 527–534, 1961.PubMedGoogle Scholar
  39. 39.
    Kurtz, A., W. Jelkmann, F. Sinowatz, and C. Bauer: Renal mesangial cell cultures as a model for study of erythropoietin production. Proc. Natl. Acad. Sci. (Usa) 80: 4008–4011, 1983.CrossRefGoogle Scholar
  40. 40.
    Lacombe, C., J. L. DA Silva, P. Bruneval, J. G. Fournier, F. Wendling, N. Casadevall, J. P. Camilleri, J. Bariety, B. Varet, and P. Tambourin: Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J. Clin. Invest. 81: 620–623, 1988.CrossRefPubMedGoogle Scholar
  41. 41.
    Lozzio, B. B., T. P. Mcdonald, and R. D. Lange: Erythropoietin formation in rats bearing congenital hydronephrosis. Isr. J. Med. Sci. 7: 1001–1006, 1971.PubMedGoogle Scholar
  42. 42.
    Malgor, L. A., and J. W. Fisher: Effects of testosterone on erythropoietin production in isolated perfused kidneys. Am. J. Physiol. 218: 1732–1736, 1970.PubMedGoogle Scholar
  43. 43.
    Mcdonald, T. P., D. H. Martin, M. L. Simmons, and R. D. Lange: Preliminary results of erythropoietin production by bovine kidney cells in culture. Life Sci. 8: 949–954, 1969.CrossRefPubMedGoogle Scholar
  44. 44.
    Mujovic, V. M., and J. W. Fisher: The effects of indomethacin on erythropoietin production in dogs following renal artery constriction. I. The possible role of prostaglandins in the generation of erythropoietin by the kidney. J. Pharmacol. Exp. Ther. 191: 575–580, 1974.Google Scholar
  45. 45.
    Naets, J. P.: Erythropoiesis in nephrectomized dogs. Nature 181: 1134–1135, 1958.CrossRefPubMedGoogle Scholar
  46. 46.
    Nielsen, O. J., S. J. Schuster, R. Kaufman, A. J. Erslev, and J. Caro: Regulation of erythropoietin production in a human hepatoblastoma cell line. Blood 70: 1904–1909, 1987.PubMedGoogle Scholar
  47. 47.
    Ogle, J. W., R. D. Lange, and C. D. R. Dunn: Erythropoiesis-stimulating factor production by rabbit kidney cultures from “programmed” rabbits. Blood 52: 233–239, 1978.PubMedGoogle Scholar
  48. 48.
    Ozawa, S.: Erythropoietin from the kidney cells cultured in vitro. Keio J. Med. 16: 193–203, 1967.Google Scholar
  49. 49.
    Pagel, H., W. Jelkmann, and C. Weiss: A comparison of the effects of renal artery constriction and anemia on the production of erythropoietin. Pflügers Arch. 413: 62–66, 1988.CrossRefPubMedGoogle Scholar
  50. 50.
    Pagel, H., W. Jelkmann, and C. Weiss: 02-supply to the kidneys and the production of erythropoietin. Respir. Physiol. 77: 111–118, 1989.CrossRefPubMedGoogle Scholar
  51. 51.
    Paul, P., S. A. Rothmann, and R. C. Meagher: Modulation of erythropoietin production by adenosine. J. Lab. Clin. Med. 112: 168–173, 1988.PubMedGoogle Scholar
  52. 52.
    Pavlovickentera, V., D. P. Hall, C. Bragassa, and R. D. Lange: Unilateral renal hypoxia and production of erythropoietin. J. Lab. Clin. Med. 65: 577–588, 1965.Google Scholar
  53. 53.
    Penington, D. G.: Erythropoietin in tissues. Features of the renal erythropoietin-producing system. In: Hormones and the Kidney, ed. P. Williams. New York: Academic Press, 1963, pp. 201–219.Google Scholar
  54. 54.
    Peschle, C., I. A. Rappaport, M. C. Magli, G. Marone, F. Lettieri, C. Cillo, and A. S. Gordon: Role of the hypophysis in erythropoietin production during hypoxia. Blood 51: 1117–1124, 1978.PubMedGoogle Scholar
  55. 55.
    Reissmann, K. R., And T. Nomura. Erythropoietin formation in isolated kidneys and liver. In: Erythropoiesis, ed. L. O. Jacobson, and M. Doyle. New York: Grune and Stratton, 1962, pp. 71–77.Google Scholar
  56. 56.
    Reissmann, K. R., T. Nomura, R. W. Gunn, and F. Brosius: Erythropoietic response to anemia or erythropoietin injection in uremic rats with or without functioning renal tissue. Blood 16: 1411–1423, 1960.PubMedGoogle Scholar
  57. 57.
    Schmid, R., and A. S. Gilbertsen: Fundamental observations on the production of compensatory polycythemia in a case of patent ductus arteriosus with reversed blood flow. Blood 10: 247–251, 1955.PubMedGoogle Scholar
  58. 58.
    Schurek, H. J., and J. M. Alt: Effect of albumin on the function of perfused rat kidney. Am. J. Physiol. 240: F569–F576, 1981.PubMedGoogle Scholar
  59. 59.
    Schuster, S. J., J. H. Wilson, A. J. Erslev, and J. Caro: Physiologic regulation and tissue localization of renal erythropoietin messenger Rna. Blood 70: 316–318, 1987.PubMedGoogle Scholar
  60. 60.
    Stohlman, F., C. E. Rath, and J. C. Rose: Evidence for a humoral regulation of erythropoiesis. Blood 9: 721–733, 1954.PubMedGoogle Scholar
  61. 61.
    Takaku, F., K. Hirashima, and K. Nakao: Studies on the mechanism of erythropoietin production. I. Effect of unilateral construction of the renal artery. J. Lab. Clin. Med. 59: 815–820, 1962.Google Scholar
  62. 62.
    Tarazi, R. C., E. D. Frohlich, H. P. Dustan, R. W. Gifford, and I. H. Page: Hypertension and high hematocrit. Am. J. Cardiol. 18: 855–858, 1966.CrossRefPubMedGoogle Scholar
  63. 63.
    Winearls, C. G., D. O. Oliver, M. J. Pippard, C. Reid, M. R. Downing, and P. M. Cotes: Effect of human erythropoietin derived from recombinant Dna on the anaemia of patients maintained by chronic hemodialysis. Lancet 2: 1175–1178, 1986.CrossRefPubMedGoogle Scholar
  64. 64.
    Zangheri, E. O., H. Campana, F. Ponce, J. C. Silva, F. O. Fernandez, and J. R. E. Suarez: Production of erythropoietin by anoxic perfusion of the isolated kidney of a dog. Nature 199: 572–573, 1963.CrossRefPubMedGoogle Scholar

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© American Physiological Society 1991

Authors and Affiliations

  • Wolfgang Jelkmann
  • Horst Pagel
  • Christoph Weiss

There are no affiliations available

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