Control of the Production of Erythropoietin by a Renal Oxygen-Sensor?

  • Wolfgang Jelkmann
  • Horst Pagel
  • Christoph Weiss
Part of the Clinical Physiology Series book series (CLINPHY)


The glycoprotein hormone erythropoietin (Epo) is an obligatory growth and differentiation factor for the erythrocytic progenitors. The plasma level of Epo in the human is about 5 to 25 mU/m1 under normoxic conditions. Tissue hypoxia is a major stimulus for erythropoiesis. The plasma level of Epo may increase to 1000 mU/ml or more after the induction of anemia or hypoxic hypoxia (12, 20, 31).


Renal Artery Patent Ductus Arteriosus Renal Blood Flow Renal Artery Stenosis Hypobaric Hypoxia 
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© American Physiological Society 1991

Authors and Affiliations

  • Wolfgang Jelkmann
  • Horst Pagel
  • Christoph Weiss

There are no affiliations available

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