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Response and Adaptation to Hypoxia pp 25–35Cite as

Regulation of Mitochondrial Distribution: An Adaptive Response to Changes in Oxygen Supply

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Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Our recent research has focused on the functional and structural changes of cells in response to changes in O2 supply. This research has been based on earlier studies that provide a working model for defining cellular O2 dependence. This model was derived from experimental data that have been presented previously in detail (3, 18, 23, 24) and analyzed and reviewed elsewhere (19–21, 24, 25). In this discussion of mitochondrial distribution in response to changes in O2 supply, we begin with a brief description of this model and a review of the factors that can affect the cellular O2 dependence. Subsequent sections consider potential mechanisms for changing cellular O2 dependence, experimental data on factors affecting the cellular O2 dependence, and potential mechanisms for changing the geometry of mitochondrial distribution.

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References

  1. Amchenkova, A. A., L. E. Bakeeva, Y. S. Chentsov, and V. P. Skulachev: Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J. Cell Biol. 107: 481–495, 1988.

    Article  PubMed  CAS  Google Scholar 

  2. AW, T. Y., and D. P. Jones: Respiratory characteristics of neonatal rat hepatocytes. Pediatr. Res. 21: 492–496, 1987.

    Article  PubMed  CAS  Google Scholar 

  3. AW, T. Y., E. Wilson, T. M. Hagen, and D. P. Jones: Determinants of mitochondrial 02 dependence in kidney. Am. J. Physiol. 253: F440–F447, 1987.

    PubMed  CAS  Google Scholar 

  4. Bai, C., C. S. Slife, T. Y. AW, and D. P. Jones: Fractionation and analysis of mitochondria with polycarbonate membrane filters. Anal. Biochem. 179: 114–119, 1989.

    Article  PubMed  CAS  Google Scholar 

  5. Boag, J. W.: Oxygen diffusion and oxygen depletion problems in radiobiology. Curr. Top. Radiat. Res. 5: 141–195, 1969.

    CAS  Google Scholar 

  6. Boag, J. W.: Cellular respiration as a function of oxygen tension. Int. J. Radiat. Biol. 18: 475–477, 1970.

    Article  CAS  Google Scholar 

  7. Chance, B.: Cellular oxygen requirements. Fed. Proc. 16: 671–680, 1957.

    PubMed  CAS  Google Scholar 

  8. Costa, L. E., A. Boveris, O. R. Koch, and A. C. Taquini: Liver and heart mitochondria in rats submitted to chronic hypobaric hypoxia. Am. J. Physiol. 255: C123–C129, 1988.

    PubMed  CAS  Google Scholar 

  9. Davis, E. J., and W. I. A. Davisvan Thienen: Control of mitochondrial metabolism by the Atp/Adp ratio. Biochem. Biophys. Res. Communie. 83: 1260–1266, 1978.

    Article  CAS  Google Scholar 

  10. Fawcett, D. W.: The cell. In: Mitochondria, 2nd ed. Philadelphia: W. B. Saunders, 1981, pp. 410–485.

    Google Scholar 

  11. Fawcett, D. W., W. A. Anderson, and D. M. Phillips: Morphogenetic factors influencing the shape of the sperm head. Dee. Biol. 26: 220–251, 1971.

    Article  CAS  Google Scholar 

  12. Fiskum, G., S. W. Craig, G. L. Decker, and A. L. Lehninger: The cytoskeleton of digitonintreated rat hepatocytes. Proc. Natl. Acad. Sci. (Usa) 77: 3430–3434, 1980.

    Article  CAS  Google Scholar 

  13. Freddo, T. F.: Mitochondria attached to desmosomes in the ciliary epithelia of human, monkey, and rabbit eyes. Cell Tissue Res. 251: 671–675, 1988.

    Article  PubMed  CAS  Google Scholar 

  14. Gronblad, M., And K. E. O. Akerman: Electron-dense endoplasmic reticulum-like profiles closely associated with mitochondria in glomus cells of the carotid body after fixation with oxalate. Expt. Cell Res. 152: 161–168, 1984.

    Article  CAS  Google Scholar 

  15. Heggeness, M. H., M. Simon, and S. J. Singer: Association of mitochondria with microtubules in cultured cells. Proc. Natl. Acad. Sci. (Usa) 75: 3863–3866, 1978.

    Article  CAS  Google Scholar 

  16. Herzfeld, A., M. Federman, and O. Greengard: Subcellular morphometric and biochemical analyses of developing rat hepatocytes. J. Cell Biol. 57: 475–483, 1973.

    Article  PubMed  CAS  Google Scholar 

  17. Hirokawa, N.: Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method. J. Cell Biol. 94: 129–142, 1982.

    Article  PubMed  CAS  Google Scholar 

  18. Jones, D. P.: Effect of mitochondrial clustering on 02 supply in hepatocytes. Am. J. Physiol. 247: C83–C89, 1984.

    PubMed  CAS  Google Scholar 

  19. Jones, D. P.: Intracellular diffusion gradients of 02 and Atp. Am. J. Physiol. 250: C663–C675, 1986.

    PubMed  CAS  Google Scholar 

  20. Jones, D. P.: New concepts of the molecular pathogenesis arising from hypoxia. In: Oxidases and Related Redox Systems, eds. T. E. King, H. S. Mason and M. Morrison. New York: Alan R. Liss, 1988, pp. 127–144.

    Google Scholar 

  21. Jones, D. P., and T. Y. AW: Mitochondrial distribution and 02 gradients in mammalian cells. In: Microcompartmentation, ed. D. P. Jones. Boca Raton, Florida: Crc Press, 1988, pp. 37–53.

    Google Scholar 

  22. Jones, D. P., T. Y. AW, B. C. Lincoln, and H. L. Bonkovsky: Oxygen concentration requirement for mitochondrial function in rat hepatocytes decreases dramatically during 2 days in primary culture. The Physiologist 30: 123, 1987.

    Google Scholar 

  23. Jones, D. P., and F. G. Kennedy: Intracellular oxygen supply during hypoxia. Am. J. Physiol. 243: C247–C253, 1982.

    PubMed  CAS  Google Scholar 

  24. Jones, D. P., and F. G. Kennedy: Analysis of intracellular oxygenation of isolated adult cardiac myocytes. Am. J. Physiol. 250: C384–C390, 1986.

    PubMed  CAS  Google Scholar 

  25. Jones, D. P., F. G. Kennedy, B. S. Andersson, T. Y. AW, and E. Wilson: When is a mammalian cell hypoxic? Insights from studies of cells versus mitochondria. Mol. Physiol. 8: 473–482, 1985.

    CAS  Google Scholar 

  26. Jones, D. P., F. G. Kennedy, and T. Y. AW: Intracellular Q gradients and the distribution of mitochondria. In: Hypoxia: The Tolerable Limits, eds. J. R. Sutton, C. S. Houston and G. Coates. Carmel, Ind.: Benchmark Press, 1988, pp. 59–69.

    Google Scholar 

  27. Kanamura, S., K. Kanai, M. Oka, Y. Shugyo, and J. Watanabe: Quantitative analysis of development of mitochondrial ultrastructure in differentiating mouse hepatocytes during postnatal period. J. Ultrastruct. Res. 93: 195–204, 1985.

    Article  PubMed  CAS  Google Scholar 

  28. Katz, J., P. A. Wals, S. Golden, and L. Raijman: Mitochondrial-reticular cytostructure in liver cells. Biochem. J. 214: 795–813, 1983.

    PubMed  CAS  Google Scholar 

  29. Kennedy, F. G., and D. P. Jones: Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes. Am. J. Physiol. 250: C374–C383, 1986.

    PubMed  CAS  Google Scholar 

  30. Kuster, U., R. Bohnensack, and W. Kunz: Control of oxidative phosphorylation by the extramitochondrial Atp/Adp ratio. Biochem. Biophys. Acta 440: 391–402, 1976.

    Article  PubMed  CAS  Google Scholar 

  31. Lindros, K. O., and K. E. Pentilla: Digitonin-collagenase perfusion for efficient separation of periportal or perivenous hepatocytes. Biochem. J. 228: 757–760, 1985.

    PubMed  CAS  Google Scholar 

  32. Loud, A. V.: A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. J. Cell Biol. 37: 27–46, 1968.

    Article  PubMed  CAS  Google Scholar 

  33. Mose-Larsen, P., R. Bravo, S. J. Fey, J. V. Small, and J. E. Cells: Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts. Cell 31: 681–692, 1982.

    Article  Google Scholar 

  34. Palmer, J. W., B. Tandler, and C. L. Hoppel: Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J. Biol. Chem. 252: 8731–8736, 1977.

    CAS  Google Scholar 

  35. Petersen, L. C., P. Nicholls, and H. Degn: The effect of energization on the apparent Michaelis-Menten constant for oxygen in mitochondrial respiration. Biochem. J. 142:247–252„ 1974.

    Google Scholar 

  36. Quistorff, B.: The use of a hepatocyte column in the study of metabolic zonation in the liver. In: Isolation, Characterization and Use of Hepatocytes, ed. R. A. Harris and N. W. Cornell. New York: Elsevier Biomedical, 1983, pp. 131–137.

    Google Scholar 

  37. Rendon, A., D. Filliol, and V. Jancsik: Microtubule associated proteins bind to 30 KD and 60 KD proteins of rat brain mitochondria: visualization by ligand blotting. Biochem. Biophys. Res. Commun. 149: 776–783, 1987.

    Article  PubMed  CAS  Google Scholar 

  38. Santander, R. G., G. M. Cuadrado, and M. R. Saez: High-energy adhering junctional complexes or with mitochondrial coupling. Histol. Histopath. 2: 153–161, 1987.

    Google Scholar 

  39. Sillau, A. H., T. Y. Aw, and D. P. Jones: 02 dependence of cytochrome c oxidation in hepatocytes from hypoxic rats. The Physiologist 34: A146, 1988.

    Google Scholar 

  40. Summerhayes, I. C., D. Wong, and L. B. Chen: Effect of microtubules and intermediate filaments on mitochondrial distribution. J. Cell Sci. 61: 87–105, 1983.

    PubMed  CAS  Google Scholar 

  41. Traub, P.: Intermediate filaments, a review. Berlin: Springer-Verlag, 1985, pp. 58–60.

    Google Scholar 

  42. Vallee, R. B., G. S. Bloom, and F. C. Luca: Differential cellular and subcellular distribution of microtubule associated proteins. In: Molecular Biology of the Cytoskeleton, ed. Borisy, G. G., Cleveland, D., Murphy, D. B. New York: Cold Spring Harbor, 1984, pp. 111–130.

    Google Scholar 

  43. Wilson, D. F., M. Erecinska, C. Drown, and I. A. Silver: The oxygen dependence of cellular metabolism. Arch. Biochem. Biophys. 195: 485–493, 1979.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Dean P. Jones
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  2. Tak Yee Aw
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  3. Changli Bai
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  4. A. H. Sillau
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Editor information

Editors and Affiliations

  1. Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Sukhamay Lahiri

  2. Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA

    Neil S. Cherniack

  3. Departments of Environmental Health, Sciences and of Physiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    Robert S. Fitzgerald

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© 1991 American Physiological Society

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Jones, D.P., Aw, T.Y., Bai, C., Sillau, A.H. (1991). Regulation of Mitochondrial Distribution: An Adaptive Response to Changes in Oxygen Supply. In: Lahiri, S., Cherniack, N.S., Fitzgerald, R.S. (eds) Response and Adaptation to Hypoxia. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7574-3_3

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  • DOI: https://doi.org/10.1007/978-1-4614-7574-3_3

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7574-3

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