Abstract
In vivo, vascular beds often respond to changes in ambient oxygen in diverse ways. For example, a decrease in oxygen concentration causes pulmonary vascular beds to vasoconstrict, while causing systemic vascular beds to vasodilate. This differential response to the same stimulus suggests some inherent difference in the oxygen-sensing mechanism or the translation of this signal within the vascular bed. Because endothelial cells are positioned such that they should be the initial cell within the vascular wall to detect a change in blood oxygen concentration, studies on the effect of acute and chronic hypoxia on these cells might define the oxygen-sensing mechanisms and uncover the inherent differences between aortic and pulmonary arterial endothelial cells. Because whole animal preparations are composed of numerous cell types, use of cultured endothelial cells would seem to be an excellent alternative to investigate the differences between endothelial cells of the two vascular beds. Until now, however, most studies have examined the effects of hypoxia on endothelial cells from a single vascular bed. In addition, endothelial cells from several different species have been used. Optimally, to obviate potential species differences or variability of animals within the same species, it would be better to use endothelial cells from both the pulmonary and the systemic circulation from the same animal and compare the responses in the same study.
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© 1991 American Physiological Society
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Farber, H.W. (1991). Differences in Pulmonary and Systemic Arterial Endothelial Cell Adaptation to Chronic Hypoxia. In: Lahiri, S., Cherniack, N.S., Fitzgerald, R.S. (eds) Response and Adaptation to Hypoxia. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7574-3_18
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DOI: https://doi.org/10.1007/978-1-4614-7574-3_18
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