Skip to main content
SpringerLink
Log in

Relationship Between Erythropoiesis and Ventilation in High Altitude Natives

  • Chapter
Response and Adaptation to Hypoxia

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Erythrocytosis, an increased rate of red blood cell production, is one of the main physiologic adjustments to hypoxia (18). The response is mediated by the glycoprotein hormone, erythropoietin, which is synthesized in the kidney (9). Upon exposure to hypoxia, the erythropoietin concentration increases in the blood of sojourners within about 6 hours (10). Peak concentrations are reached in about 48 hours, and significant elevations can still be measured after 9 days (1). After that, the serum erythropoietin concentration is indistinguishable from sea-level normal. It is not known whether variation in the erythropoietin response can explain the variation in hematocrit observed in sojourners to altitude, but based on a few subjects (14), there seems to be no striking correlation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abbrecht, P. H., And J. K. Littel. Plasma erythropoietin in men and mice during acclimatization to different altitudes. J. Appl. Physiol. 32 (1): 54 - 58, 1972.

    PubMed  CAS  Google Scholar 

  2. Adams, W. H., And S. M. Shresta. Hemoglobin levels, vitamin B12, and folate status in a Himalayan village. Am. J. Physiol. 27:217-219, 1974.

    Google Scholar 

  3. Adams, W. H., And L. Strang. Hemoglobin levels in persons of Tibetan ancestry living at high altitude. Proc. Soc. Exp. Biol. Med. 149:1036-1039, 1975.

    Google Scholar 

  4. Beall, C. M. Reappraisal of Andean high altitude erythrocytosis from a Himalayan perspective. Semin. Respir. Med. 5 (2): 195 - 201, 1983.

    Article  Google Scholar 

  5. Beall, C. M., And A. B. Reichsman. Hemoglobin levels in a Himalayan high altitude population. Am. J. Physiol. 63: 301 - 306, 1984.

    CAS  Google Scholar 

  6. Beall, C. M. Hemoglobin concentration of pastural nomad permanent residents of 48505450 m in Tibet. Am. J. Phys. Anthrop. 73: 433 - 438, 1987.

    Article  Google Scholar 

  7. Blume, F. D., R. Santolaya, M. G. Sherpa, And C. C. Monge. Anthropometric and lung volume measurements in Himalayan and Andean natives. Faseb J. 2(5):Al281, 1988.

    Google Scholar 

  8. Coslo, G. Trabajo minero a gran altura y los valores hematicos. Boletin Instituto de Salud Occupacional, Lima 10: 5 - 12, 1965.

    Google Scholar 

  9. Erslev, A. J., J. Wilson, And J. Caro. Erythropoeitin titers in anemic, nonuremic patients. J. Lab. Clin. Med. 109: 429 - 433, 1987.

    PubMed  CAS  Google Scholar 

  10. Faura, J., J. Ramos, C. Reynafarje, E. English, P. Finne, And C. Finch. Effect of altitude on erythropoiesis. Blood 33 (5): 668 - 676, 1969.

    CAS  Google Scholar 

  11. Hackett, P. H., J. T. Reeves, R. F. Grover, And J. V. Weil. Ventilation in human popula- tions native to high altitude. In: Man at High Altitude, eds. J. B. West and S. Lahiri. Bethesda, MD: American Physiological Society, 1984, pp. 179 - 191.

    Google Scholar 

  12. Huang, S. Y., X. H. Ning, Z. N. Zhou, Z. Z. Gu, And S. T. Hu. Ventilatory function in adaptation to high altitude: studies in Tibet. In: Man at High Altitude, eds. J. B. West and S. Lahiri. Bethesda, MD: American Physiological Society, 1984, pp. 173 - 177.

    Google Scholar 

  13. Merino, C. F. The plasma erythropoietic factor in the polycythemia of high altitudes. Report 56-103 to the Air University, School of Aviation Medicine, Usaf, Randolph Afb, Texas, 1956, p. 103.

    Google Scholar 

  14. Milledge, J. S., And P. M. Cotes. Serum erythropoietin in humans at high altitude and its relation to plasma renin. J. Appl. Physiol. 59: 360 - 364. 1985.

    PubMed  CAS  Google Scholar 

  15. Reynafarje, C., J. Ramos, J. Faura, And D. Villavicencio. Humoral control of erythropoietic activity in man during and after altitude exposure. Proc. Soc. Exp. Biol. Med. 116: 649 - 650, 1964.

    PubMed  CAS  Google Scholar 

  16. Samaja, M., A. Veicsteinas, And P. Cerretelli. Oxygen affinity of blood in altitude Sherpas. J. Appl. Physiol. 47 (2): 337 - 341, 1979.

    PubMed  CAS  Google Scholar 

  17. Sherwood, J. B., And E. Goldwasser. A radioimmunoassay for erythropoietin. Blood 54 (4): 885 - 893, 1979.

    PubMed  CAS  Google Scholar 

  18. Viault, F. Sur l'augmentation considerable du nombres des globules rouges dans le sang chez les habitants des hautes plateaux de l'Amerique du Sud. Compt. Rend. Soc. Biol. (Paris) 30: 917 - 918, 1890.

    Google Scholar 

  19. Weil, J. V., E. Bryne-Quinn, I. E. Solal, G. F. Filly, And R. F. Grover. Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J. Clin. Invest. 50: 186 - 195, 1972.

    Google Scholar 

  20. Whittembury, J., And C. Monge C. High altitude, hematocrit, and age. Nature(London) 238: 278 - 279, 1976.

    Article  Google Scholar 

  21. Winslow, R. M., C. C. Monge, N. J. Statham, C. G. Gibson, S. Charache, J. Whittembury, O. Moran, And R. L. Berger. Variability of oxygen affinity of blood: human subjects native to high altitude. J. Appl. Physiol. 51: 1411 - 1416, 1981.

    CAS  Google Scholar 

  22. Winslow, R. M., And S. S. Mckneally. Analysis of breath-by-breath exercise data from field studies. Int. J. Clin. Monit. Comput. 2: 167 - 190, 1986.

    Article  PubMed  CAS  Google Scholar 

  23. Winslow, R. M., And C. Monge. Hypoxia, Polycythemia, and Chronic Mountain Sickness. Baltimore, Johns Hopkins University Press, 1987.

    Google Scholar 

  24. Winslow, R. M., K. W. Chapman, C. C. Gibson, M. Samaja, C. C. Monge, E. Goldwasser, M. Sherpa, F. D. Blume, And R. Santolaya. Different hematologic responses to hypoxia in Sherpas and Quechua Indians. J. Appl. Physiol. 66: 1561 - 1569, 1989.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Robert M. Winslow
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Sukhamay Lahiri

  2. Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA

    Neil S. Cherniack

  3. Departments of Environmental Health, Sciences and of Physiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    Robert S. Fitzgerald

Rights and permissions

Reprints and permissions

Copyright information

© 1991 American Physiological Society

About this chapter

Cite this chapter

Winslow, R.M. (1991). Relationship Between Erythropoiesis and Ventilation in High Altitude Natives. In: Lahiri, S., Cherniack, N.S., Fitzgerald, R.S. (eds) Response and Adaptation to Hypoxia. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7574-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7574-3_13

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7574-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation