Animal Pain pp 179-205 | Cite as

Evaluation of Analgesic Drugs in Horses

  • William V. Lumb
  • Ney L. Pippi
  • Marissak Kalpravidh

Abstract

Of the domesticated species of animals, horses are probably most refractory to effects of analgesic drugs. At the same time, a great need exists for effective agents that produce a sedative and analgesic effect in this species. A striking example of this occurred in 1975 when the magnificent filly, Ruffian, broke her leg in a match race at New York’s Belmont Park. She was treated by a team of four veterinarians and an orthopedic surgeon. During recovery from anesthesia she struggled desperately and destroyed the fixation device that had been applied. A decision for euthanasia was made 8 h after the race.

Keywords

Placebo Respiration Prostaglandin Hydrochloride Fentanyl 

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References

  1. 1.
    Beecher, H. K. The measurement of pain: prototype for the quantitative study of subjective responses. Pharm. Rev. 9: 59–209, 1957.PubMedGoogle Scholar
  2. 2.
    Booth, N. H. Neuroleptanalgesics, narcotic analgesics, and analgesic antagonists. In: Veterinary Pharmacology and Therapeutics ( 4th ed. ). Ames: Iowa State Univ. Press, 1977, p. 318–350.Google Scholar
  3. 3.
    Brown, A. K. Levorphan in anaesthesia. Br. Med. J. 2: 967–969, 1954.CrossRefPubMedGoogle Scholar
  4. 4.
    Brunson, D. V., M. A. Collier, and E. A. Scott. Dental dolorimetry as a method for pain threshold studies in the equine species. Annu. Sci. Meet. Am. Assoc. Vet. Anesth., 2nd, New Orleans, October 1981.Google Scholar
  5. Casy, A. F.: The structure of narcotic analgesic drugs. In: Narcotic Drugs: Biochemical Pharmacology. New York: Plenum, 1971, p. 1–16.Google Scholar
  6. 6.
    Chapman, W. P., and C. M. Jones. Variations in cutaneous and visceral pain sensitivity in normal subjects. J. Clin. Invest. 23: 81–91, 1944.CrossRefGoogle Scholar
  7. 7.
    Charpentier, J. Analyse de l’action de la morphine chez le rat par une nouvelle methode quantitative. C. R. Acad. Sci. Ser. D 255: 2285–2287, 1962.Google Scholar
  8. 8.
    Ciofalo, V. V., M. B. Latranyi, J. B. Patel, and R. I. Taber. Flunixin meglumine: a non-narcotic analgesic. J. Pharmacol. Exp. Ther. 200: 501–507, 1977.PubMedGoogle Scholar
  9. 9.
    Clarke, K. W., and L. W. Hall. Xylazine-a new sedative for horses and cattle. Vet. Rec. 85: 512–517, 1969.CrossRefPubMedGoogle Scholar
  10. 10.
    Combie, J., J. Dougherty, E. Nugent, and T. Tobin. The pharmacology of narcotic analgesics in the horse. IV. Dose and time response relationships for behavioral responses of morphine, meperidine, pentazocine, anileridine, methadone, and hydromorphone. J. Equine Med. Surg. 3: 377–385, 1979.Google Scholar
  11. 11.
    Crago, T. G. The use of Innovar-vet injection in canine cesarean sections. Pract. Vet. 44: 5, 1972.Google Scholar
  12. 12.
    Davis, L. E., and B. L. Strum. Drug effects and plasma concentrations of pentazocine in domestic animals. Am. J. Vet. Res. 31: 1631–1635, 1970.Google Scholar
  13. 13.
    Del Pizzo, A. Butorphanol, a new intravenous analgesic: double-blind comparison with morphine sulfate in postoperative patients with moderate or severe pain. Curr. Ther. Res. Clin. Exp. 20: 221–232.Google Scholar
  14. 14.
    Dobkin, A. B., S. Eamkaow, and F. S. Caruso. Butorphanol and pentazocine in patients with severe postoperative pain. Clin. Pharmacol. Ther. 18: 547–553, 1975.PubMedGoogle Scholar
  15. 15.
    Dobkin, A. B., S. Eamkaow, S. Zak, and F. S. Caruso. Butorphanol: a double-blind evaluation in postoperative patients with moderate or severe pain. Can. Anaesth. Soc. J. 21: 600–610, 1974.CrossRefPubMedGoogle Scholar
  16. 16.
    Edy, N. B., H. Halbacah, and O. J. Braenden. Synthetic substances with morphine-like effect: clinical experience, potency, side effects, addiction liability. Bull. WHO 17: 569–573, 1957.Google Scholar
  17. 17.
    Emmons, M. S., F. B. Coslin, M. W. Safley, and R. T. Tidrick. Use of levorphan tartrate for relief of postoperative pain: preliminary report. Lancet 75: 29–31, 1955.Google Scholar
  18. 18.
    Gaard, R. C. Postoperative use of levo-dromoran tartrate. Lancet 75: 309–310, 1955.Google Scholar
  19. 19.
    Ganong, W. F. Review of Medical Physiology ( 8th ed. ). Los Altos, CA: Lange Med., 1977.Google Scholar
  20. 20.
    Gardocki, J. F., and J. Yelnosky. A study of some of the pharmacologic actions of fentanyl citrate. Toxicol. Appl. Pharmacol. 6: 48–62, 1964.CrossRefPubMedGoogle Scholar
  21. 21.
    Goetzl, F. R., D. Y. Burrill, and A. C. Ivy. A critical analysis of algesimetric methods with suggestions for a useful procedure. Q. Bull. Northwest. Univ. Med. Sch. 17: 280–291, 1943.Google Scholar
  22. 22.
    Hall, L. W. Wright’s Veterinary Anaesthesia and Analgesia ( 7th ed. ). London: Bail-here, Tindall, and Cox, 1971, p. 151–153.Google Scholar
  23. 23.
    Hardy, J. D., H. G. Wolff, and H. Goodell. Pain Sensations and Reactions. New York: Hafner, 1967.Google Scholar
  24. 24.
    Hardy, J. D., H. G. Wolff, and H. Goodell. Studies on pain-a new method for measuring pain threshold: observations on spatial summation of pain. J. Clin. Invest. 19: 649–657, 1940.CrossRefPubMedGoogle Scholar
  25. 25.
    Harris, L. S. Structure-activity relationships. In: Narcotic Drugs: Biochemical Pharmacology, edited by D. H. Clouet. New York: Plenum, 1971, p. 89–98.CrossRefGoogle Scholar
  26. 26.
    Hoffman, P. E. Clinical evaluation of xylazine as a chemical restraining agent, sedative, and analgesic in horses. J. Am. Vet. Med. Assoc. 164: 42–45, 1974.PubMedGoogle Scholar
  27. 27.
    Houdeshell, J. W., and P. W. Hennessey. A new nonsteroidal, anti-inflammatory analgesic for horses. J. Equine Med. Surg. 1: 57–63, 1977.Google Scholar
  28. 28.
    Hsu, W. H. Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J. Pharmacol. Exp. Ther. 218: 188–192, 1981.PubMedGoogle Scholar
  29. 29.
    Huber, D. E. A useful clinic aid. J. Am. Anim. Hosp. Assoc. 7: 256–258, 1971.Google Scholar
  30. 30.
    Hunt, R. D., and F. F. Foldes. The use of levo-dromoran tartrate (levorphan tartrate) for relief of postoperative pain. N. Engl. J. Med. 248: 803–805, 1953.CrossRefPubMedGoogle Scholar
  31. 31.
    Jaffe, J. H., and W. R. Martin. Opioid analgesics and antagonists. In: The Pharmacological Basis of Therapeutics (6th ed.), edited by A. G. Gilman, L. S. Goodman, and A. Gilman. New York: Macmillan, 1980, p. 494–534.Google Scholar
  32. 32.
    Klein, L. V., and C. Baetjer. Preliminary report: xylazine and morphine sedation in horses. Vet. Anesth. 1: 2–6, 1974.Google Scholar
  33. 33.
    Krahwinkel, D. J., D. C. Sawyer, and A. T. Evans. Neuroleptanalgesia and neuroleptanesthesia. J. Am. Anim. Hosp. Assoc. 8: 368–370, 1972.Google Scholar
  34. 34.
    Kerr, D. D., E. W. Jones, K. Huggins, and W. C. Edwards. Sedative and other effects of xylazine given intravenously to horses. Am. J. Vet. Res. 33: 525–532, 1972.PubMedGoogle Scholar
  35. 35.
    Lahoda, R., G. Stacher, and P. Bauer. Experimentally induced pain: measurement of pain threshold and pain tolerance using a new apparatus for electrical stimulation of the skin. Int. J. Clin. Pharmacol. Biopharm. 15: 51–56, 1977.PubMedGoogle Scholar
  36. 36.
    Lasagna, L. The clinical evaluation of morphine and its substitutes as analgesics. Pharmacol. Rev. 16: 47–83, 1964.PubMedGoogle Scholar
  37. 37.
    Laubie, M., H. Schmitt, and M. Drovillat. Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl. Naunyn-Schmiedeberg’s Arch. Pharmacol. 269: 255–261, 1977.Google Scholar
  38. 38.
    Leek, B. F. Reticulo-ruminal mechanoreceptors in sheep. J. Physiol. London 202: 585–609, 1969.PubMedGoogle Scholar
  39. 39.
    Leek, B. F. Abdominal and pelvic visceral receptors. Br. Med. Bull. 33: 163–168, 1977.PubMedGoogle Scholar
  40. 40.
    Lowe, J. E. Pentazocine (Talwin-V) for the relief of abdominal pain in ponies-a comparative evaluation with description of a colic model for analgesia evaluation. Proc. Am. Assoc. Equine Pract. 15: 31–46, 1969.Google Scholar
  41. 41.
    Lumb, W. V., and E. W. Jones. Veterinary Anesthesia. Philadelphia, PA: Lea and Febiger, 1973.Google Scholar
  42. 42.
    Mackenzie, G. The effect of various tranquilizers in combination with etorphine to produce neuroleptanalgesia in ponies. Proc. Assoc. Vet. Anaesth. Gr. Br. Ire. 5: 40–49, 1975.CrossRefGoogle Scholar
  43. 43.
    Maxwell, D. R., H. T. Palmer, and R. W. Ryall. A comparison of the analgesic and some other central properties of methotrimeprazine and morphine. Arch. Int. Pharmacodyn. Ther. 132: 60–73, 1961.PubMedGoogle Scholar
  44. 44.
    McCarty, J. D. An effective restraint in clinical procedures. J. Am. Anim. Hosp. Assoc. 6: 43–44, 1970.Google Scholar
  45. McCashin, F. B., and A. A. Gabel. Rompun—a new sedative with analgesic properties. In: Proc. Annu. Meet. Am. Assoc. Equine Pract., 17th, 1971, p. 111–118.Google Scholar
  46. 46.
    McCashin, F. B., and A. A. Gabel. Evaluation of xylazine as a sedative and pre-anesthetic agent in horses. Am. J. Vet. Res. 36: 1421–1429, 1975.PubMedGoogle Scholar
  47. 47.
    Miller, L. C. A critique of analgesic testing methods. Ann. NY Acad. Sci. 51: 34–50, 1948.CrossRefPubMedGoogle Scholar
  48. 48.
    Nilsen, P. L. Studies on algesimetry by electrical stimulation of the mouse tail. Acta Pharmacol. Toxicol. 18: 10–22, 1961.CrossRefGoogle Scholar
  49. 49.
    Nytch, T. F. Clinical observations on the preanesthetic use of oxymorphone and its antagonist, N-allyl-noroxymorphone, in dogs. J. Am. Vet. Med. Assoc. 145: 127–131, 1964.Google Scholar
  50. 50.
    Palminteri, A. Oxymorphone, an effective analgesic in dogs and cats. J. Am. Vet. Med. Assoc. 143: 160–163, 1963.PubMedGoogle Scholar
  51. 50a.
    Pippi, N. L., and W. V. Lumb. Objective tests of analgesic drugs in ponies. Am. J. Vet. Res. 40: 1082–1086, 1979.PubMedGoogle Scholar
  52. 51.
    Pippi, N. L., W. V. Lumb, S. A. G. Fialho, and R. J. Scott. A model for evaluating pain in ponies. J. Equine Med. Surg. 3: 430–435, 1979.Google Scholar
  53. 52.
    Pircio, A. W., J. A. Gylys, R. L. Cavanagh, J. P. Buyniski, and M. E. Bierwagen. The pharmacology of butorphanol, a 3,14-dihydroxymorphinan narcotic antagonist analgesic. Arch. Int. Pharmacodyn. Ther. 220: 231–257, 1976.PubMedGoogle Scholar
  54. 53.
    Reed, S. M., and W. M. Bayly. Medical management of acute abdominal crises. Mod. Vet. Pract. 61: 543–546, 1980.PubMedGoogle Scholar
  55. 54.
    Schauffler, A. F. Acetylpromazine + methadone = better equine restraint. Mod. Vet. Pract. 50: 46–49, 1969.Google Scholar
  56. 55.
    Soma, L. R. Textbook of Veterinary Anesthesia. Baltimore, MD: Williams and Wilkins, 1971, p. 121–128.Google Scholar
  57. 56.
    Tavakoli, M., G. Corssen, and F. S. Caruso. Butorphanol and morphine: a double-blind comparison of their parenteral analgesic activity. Anesth. Analg. Cleveland 55: 394–401, 1976.PubMedGoogle Scholar
  58. 57.
    Tobin, T. Pharmacology review: narcotic analgesics and the opiate receptor in the horse. J. Equine Med. Surg. 2: 397–399, 1978.Google Scholar
  59. 58.
    Vernimb, G. D., and P. W. Hennessey. Clinical studies on flunixin meglumine in the treatment of equine colic. J. Equine Med. Surg. 1: 111–116, 1977.Google Scholar

Copyright information

© American Physiological Society 1983

Authors and Affiliations

  • William V. Lumb
    • 1
  • Ney L. Pippi
    • 2
  • Marissak Kalpravidh
    • 3
  1. 1.Department of Clinical Sciences, College of Veterinary Medicine and Biomedical SciencesColorado State UniversityFort CollinsUSA
  2. 2.Escola de VeterinariaUniversidade Federal de Santa MariaRio Grande do SulBrazil
  3. 3.Faculty of Veterinary Sciences, Department of SurgeryChulalongkorn UniversityBangkokThailand

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