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Species Differences in Drug Disposition as Factors in Alleviation of Pain

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Animal Pain

Abstract

The veterinarian has an absolute ethical obligation to alleviate pain and suffering in his animal patients. This commitment stems from the purposes of the profession, which every veterinarian swears to espouse (5). The fulfillment of this obligation may often be difficult because the veterinarian is asked to care for the health of the entire animal kingdom, with the exception of human beings. The essence of veterinary pharmacology, as opposed to human medical pharmacology, lies in the species differences existing in the effects, actions, disposition, dosage, and other properties of drugs (6). Among mammalian species, there is little difference in the actions and effects of various drugs (10); the principal variables affecting intensity of pharmacological effects are drug absorption, distribution, excretion, and biotransformation.

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References

  1. Alexander, F., and R. A. Collett. Pethidine in the horse. Res. Vet. Sci. 17: 136–137, 1974.

    PubMed  CAS  Google Scholar 

  2. Benson, G. J., and J. C. Thurmon. Anesthesia of swine under field conditions. J. Am. Vet. Med. Assoc. 174: 594–596, 1979.

    CAS  Google Scholar 

  3. Boulos, B. M., W. L. Jenkins, and L. E. Davis. Pharmacokinetics of certain drugs in the domesticated goat. Am. J. Vet. Res. 33: 943–952, 1972.

    CAS  Google Scholar 

  4. Clarke, K. W., and L. W. Hall. Xylazine. A new sedative for horses and cattle. Vet. Rec. 85: 512–517, 1969.

    Article  PubMed  CAS  Google Scholar 

  5. Davis, L. E. A perspective on drug therapy in veterinary medicine. In: Proc. Equine Pharmacol. Symp., 2nd, edited by J. D. Powers and T. E. Powers. Golden, CO: Am. Assoc. Equine Practitioners, 1978, p. 9–16.

    Google Scholar 

  6. Davis, L.E. The challenge of veterinary pharmacology. Trends Pharmacol. Sci. 1: 295–299, 1980.

    CAS  Google Scholar 

  7. Davis, L. E., C. A. Davis, and J. D. Baggot. Comparative pharmacokinetics in domesticated animals. In: Research Animals in Medicine, edited by L. H. Harmison. Bethesda, MD: Harmison. 1973, 72–333, p. 715–733.

    Google Scholar 

  8. Davis, L. E., and E. J. Donnelly. Analgesic drugs in the cat. J. Am. Vet. Med. Assoc. 153: 1161–1167, 1968.

    PubMed  CAS  Google Scholar 

  9. Davis, L. E., and W. L. Jenkins. Some considerations regarding drug therapy in ruminant animals. Bovine Pract. 9: 57–60, 1974.

    Google Scholar 

  10. Davis, L. E., C. A. Neff-Davis, and J. R. Wilcke. Monitoring drug concentrations in animal patients. J. Am. Vet. Med. Assoc. 176: 1156–1158, 1980.

    PubMed  CAS  Google Scholar 

  11. Davis, L. E., and B. L. Sturm. Plasma levels and effects of pentazocine in domesticated animals. Am. J. Vet. Res. 31: 1631–1635, 1970.

    PubMed  CAS  Google Scholar 

  12. Davis, L. E., and B. A. Westfall. Species differences in the biotransformation and excretion of salicylate. Am. J. Vet. Res. 33: 1253–1262, 1972.

    PubMed  CAS  Google Scholar 

  13. Dayton, P. G., Z. H. Israili, and J. M. Perel. Influence of binding on drug metabolism and distribution. Ann. NY Acad. Sci. 226: 172–194, 1973.

    Article  PubMed  CAS  Google Scholar 

  14. DeBacker, P., R. Braeckman, F. Belpaire, and M. Debackere. Bioavailability and pharmacokinetics of phenylbutazone in the cow. J. Vet. Pharmacol. Ther. 3: 29–33, 1980.

    Article  CAS  Google Scholar 

  15. Eberhardson, B., G. Olsson, L. Appelgren, and S. Jacobsson. Pharmacokinetic studies of phenylbutazone in cattle. J. Vet. Pharmacol. Ther. 2: 31–37, 1979.

    Article  CAS  Google Scholar 

  16. Eichner, R. D., R. L. Prior, and W. G. Kuasnicka. Xylazine-induced hyperglycemia in beef cattle. Am. J. Vet. Res. 40: 127–129, 1979.

    CAS  Google Scholar 

  17. Garcia-Villar, R., P. L. Toutain, M. Alvinerie, and Y. Ruckebusch. The pharmacokinetics of xylazine hydrochloride: an interspecific study. J. Vet. Pharmacol. Ther. 4: 87–92, 1981.

    Article  PubMed  CAS  Google Scholar 

  18. Garrett, E. R., and T. Gurkan. Pharmacokinetics of morphine and its surrogates. IV. Pharmacokinetics of heroin and its derived metabolites in dogs. J. Pharm. Sci. 69: 1116–1134, 1980.

    Article  PubMed  CAS  Google Scholar 

  19. Getty, R. Sisson and Grossman’s The Anatomy of the Domestic Animals (5th ed.). Philadelphia, PA: Saunders, 1975, vol. I.

    Google Scholar 

  20. Gingerich, D. A., J. D. Baggot, and R. A. Yeary. Pharmacokinetics and dosage of aspirin in cattle. J. Am. Vet. Med. Assoc. 167: 945–948, 1975.

    PubMed  CAS  Google Scholar 

  21. Hazum, E., J. J. Sabatka, K. Chang, D. A. Brent, J. W. A. Findlay, and P. Cuatrecasas. Morphine in cow and human milk: could dietary morphine constitute a ligand for specific morphine (µ) receptors? Science 213: 1010–1012, 1981.

    Article  PubMed  CAS  Google Scholar 

  22. Hucker, H. B. Species differences in drug metabolism. Annu. Rev. Pharmacol. 10: 99–118, 1970.

    Article  PubMed  CAS  Google Scholar 

  23. Hug, C. C., Jr., M. R. Murphy, E. P. Rigel, and W. A. Olson. Pharmacokinetics of morphine injected intravenously into the anesthetized dog. Anesthesiology 54: 3847, 1981.

    Article  Google Scholar 

  24. Hvidberg, E. F., and F. Rasmussen. Pharmacokinetics of phenylbutazone and oxyphenbutazone in the pig. Can. J. Comp. Med. 39: 80–88, 1975.

    PubMed  CAS  Google Scholar 

  25. Jenkins, W. L. Drug Distribution Across the Ruminai Epithelium. Columbia: Univ. of Missouri, 1969. PhD thesis.

    Google Scholar 

  26. Jenkins, W. L., and L. E. Davis. Transfer of drugs across the ruminal wall of goats. Am. J. Vet. Res. 36: 1771–1776, 1975.

    CAS  Google Scholar 

  27. Loan, W. B., and J. D. Morrison. Strong analgesics: pharmacological and therapeutic aspects. Drugs 5: 108, 1973.

    Article  CAS  Google Scholar 

  28. Marriner, S., and J. A. Bogan. The influence of the rumen on the absorption of drugs: studies using neclofenamic acid administered by various routes to sheep and cattle. J. Vet. Pharmacol. Ther. 2: 109–115, 1979.

    Article  CAS  Google Scholar 

  29. Newkirk, H. L., and D. G. Miles. Xylazine as a sedative analgesic for dogs and cats. Mod. Vet. Pract. 55: 677–680, 1974.

    CAS  Google Scholar 

  30. Palminteri, A. Oxymorphone, an effective analgesic in dogs and cats. J. Am. Vet. Med. Assoc. 143: 160–163, 1963.

    PubMed  CAS  Google Scholar 

  31. Piperno, E., D. J. Ellis, S. M. Getty, and T. M. Brody. Plasma and urine levels of phenylbutazone in the horse. J. Am. Vet. Med. Assoc. 153: 195–198, 1968.

    PubMed  CAS  Google Scholar 

  32. Richez, P., A. Regnier, and Y. Ruckebush. Influence of food intake on the absorption of lysine-acetylsalicylate in dogs. J. Vet. Pharmacol. Ther. 3: 121–124, 1980.

    Article  CAS  Google Scholar 

  33. Spector, S. Disposition of drugs in man by radioimmunoassay. Pharmacol. Rev. 34: 73–75, 1982.

    PubMed  CAS  Google Scholar 

  34. Stevens, C. E. Comparative physiology of the digestive system. In: Dukes’ Physiology of Domestic Animals (9th ed.), edited by M. J. Swenson. Ithaca, NY: Comstock, 1977, p. 222.

    Google Scholar 

  35. Thurmon, J. C., C. A. Neff-Davis, L. E. Davis, R. A. Stoker, G. J. Benson, and T. F. Lock. Xylazine hydrochloride induces hyperglycemia and hypoinsulinemia in thoroughbred horses. J. Vet. Pharmacol. Ther. 5: 241–245, 1982.

    Article  PubMed  CAS  Google Scholar 

  36. Vernimb, G. D., and P. W. Hennessey. Clinical studies on flunixin meglumine in the treatment of equine colic. J. Equine Med. Surg. 1: 111–116, 1977.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Clinical Pharmacology Studies Unit, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA

    Lloyd E. Davis

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  1. Lloyd E. Davis
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Editor information

Editors and Affiliations

  1. Department of Anatomy, School of Veterinary Medicine, University of California, Davis, California, USA

    Ralph L. Kitchell

  2. Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA

    Howard H. Erickson

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© 1983 American Physiological Society

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Davis, L.E. (1983). Species Differences in Drug Disposition as Factors in Alleviation of Pain. In: Kitchell, R.L., Erickson, H.H. (eds) Animal Pain. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7562-0_10

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  • DOI: https://doi.org/10.1007/978-1-4614-7562-0_10

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7562-0

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