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Tools for Assessing Lipoprotein Metabolism in Diabetes Mellitus

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Lipoproteins in Diabetes Mellitus

Part of the book series: Contemporary Diabetes ((CDI))

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Abstract

Understanding the whole body (systemic) and cellular metabolism of lipoproteins, including that of the modified lipoproteins that occur in diabetes mellitus, has potential to improve the quantitative and qualitative changes in lipoproteins that contribute to the macrovascular and microvascular complications of type 1 and type 2 diabetes [1, 2] and facilitate development of therapeutics that can improve clinical outcomes. An excellent example of how understanding lipoprotein metabolism has improved clinical outcomes is that an understanding of the LDL receptor, intracellular cholesterol metabolism, and the central role of HMG-CoA reductase led to the development of HMG-CoA reductase inhibitors (statins), which substantially reduce cardiovascular events in both diabetic and nondiabetic people [3–5].

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Acknowledgements

This work was supported in part by the Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs. The contents of this document do not represent the views of the Department of Veterans Affairs or the United States Government. The author also acknowledges the contributions of his collaborators Professors John Baynes and Susan Thorpe, Timothy Lyons, Maria Lopes-Virella, Ms. Andrea Semler, and the DCCT/EDIC Research Group.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Clinical Science Building, 8th Floor, 96 Jonathan Lucas Street, Charleston, SC, 29425, USA

    Richard L. Klein Ph.D.

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  1. Richard L. Klein Ph.D.
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Correspondence to Richard L. Klein Ph.D. .

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Editors and Affiliations

  1. NHMRC Clinical Trials Centre, University of Sydney, Sydney, Australia

    Alicia J. Jenkins

  2. College of Medicine, University of Illinois, Peoria, Illinois, USA

    Peter P. Toth

  3. Section of Endocrinology and Diabetes Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Timothy J. Lyons

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Klein, R.L. (2014). Tools for Assessing Lipoprotein Metabolism in Diabetes Mellitus. In: Jenkins, A., Toth, P., Lyons, T. (eds) Lipoproteins in Diabetes Mellitus. Contemporary Diabetes. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7554-5_12

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  • DOI: https://doi.org/10.1007/978-1-4614-7554-5_12

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4614-7553-8

  • Online ISBN: 978-1-4614-7554-5

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