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Differences in Fertility and Assisted Reproduction in South Asian Women

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Ethnic Differences in Fertility and Assisted Reproduction

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Abstract

Recently, interest in ethnic-mediated disparities in assisted reproductive technology (ART) outcomes has been increasing. Studies report that a large proportion of South Asian women experience infertility as a consequence of anovulatory endocrinopathies, most commonly caused by PCOS. South Asian patients with infertility may be phenotypically different from their Caucasian counterparts, which may affect the outcomes of ART. Here we review the current literature evaluating ART outcomes in South Asian women.

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References

  1. Baker VL, Luke B, Brown MB, et al. Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. Fertil Steril. 2010;94(4):1410–6.

    Article  PubMed  Google Scholar 

  2. Seifer DB, Zackula R, Grainger DA. Trends of racial disparities in assisted reproductive technology outcomes in black women compared with white women: Society for Assisted Reproductive Technology 1999 and 2000 vs. 2004–2006. Fertil Steril. 2010;93(2):626–35.

    Article  PubMed  Google Scholar 

  3. National Survey of Family Growth. http://cdc.gov/nchs/nsfg.htm (2012). Accessed 20 Aug 2012.

  4. Wang ET, Fujimoto VY, Yeaton-Massey AJ, Vittinghoff E, Caughey AB, Huddleston HG. Asian ethnicity and fecundability in women with spontaneous conceptions. Fertil Steril. 2011;95(8):2769–71.

    Article  PubMed  Google Scholar 

  5. Lamb JD, Huddleston HG, Purcell KJ, et al. Asian ethnicity is associated with decreased pregnancy rates following intrauterine insemination. Reprod Biomed Online. 2009;19(2):252–6.

    Article  PubMed  Google Scholar 

  6. Jain T. Socioeconomic and racial disparities among infertility patients seeking care. Fertil Steril. 2006;85(4):876–81.

    Article  PubMed  Google Scholar 

  7. Greil AL, McQuillan J, Shreffler KM, Johnson KM, Slauson-Blevins KS. Race-ethnicity and medical services for infertility: stratified reproduction in a population-based sample of U.S. women. J Health Soc Behav. 2011;52(4):493–509.

    Article  PubMed  Google Scholar 

  8. Johnstone E, Sandler JR, Addauan-Andersen C, Sohn SH, Fujimoto VY. Asian women are less likely to express interest in infertility research. Fertil Steril. 2010;94(4):1249–53.

    Article  PubMed  Google Scholar 

  9. Prevention CfDCa. Assisted reproductive technology success rates. National Summary and Fertility Clinic Reports, Atlanta, GA; 2011.

    Google Scholar 

  10. Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin Endocrinol (Oxf). 1998;49(1):91–9.

    Article  CAS  Google Scholar 

  11. Wijeyaratne CN, Balen AH, Barth JH, Belchetz PE. Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: is there a difference? Clin Endocrinol (Oxf). 2002;57(3):343–50.

    Article  CAS  Google Scholar 

  12. Ghosh K, Chowdhury JR. Tuberculosis and female reproductive health. J Postgrad Med. 2011;57(4):307–13.

    Article  PubMed  CAS  Google Scholar 

  13. Singh N, Sumana G, Mittal S. Genital tuberculosis: a leading cause for infertility in women seeking assisted conception in North India. Arch Gynecol Obstet. 2008;278(4):325–7.

    Article  PubMed  Google Scholar 

  14. Varma TR. Genital tuberculosis and subsequent fertility. Int J Gynaecol Obstet. 1991;35(1):1–11.

    Article  PubMed  CAS  Google Scholar 

  15. Shahine LK, Lamb JD, Lathi RB, Milki AA, Langen E, Westphal LM. Poor prognosis with in vitro fertilization in Indian women compared to Caucasian women despite similar embryo quality. PLoS One. 2009;4(10):e7599.

    Article  PubMed  Google Scholar 

  16. Sharara FI, Fouany MR, Sharara YF, Abdo G. Racial differences in ART outcome between white and South Asian women. Middle East Fertil Soc J 2011;17(2):89–92.

    Google Scholar 

  17. Marshall LM, Spiegelman D, Barbieri RL, et al. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol. 1997;90(6):967–73.

    Article  PubMed  CAS  Google Scholar 

  18. Wellons MF, Fujimoto VY, Baker VL, et al. Race matters: a systematic review of racial/ethnic disparity in society for assisted reproductive technology reported outcomes. Fertil Steril. 2012;98(2):406–9.

    Article  PubMed  Google Scholar 

  19. Palep-Singh M, Picton HM, Vrotsou K, Maruthini D, Balen AH. South Asian women with polycystic ovary syndrome exhibit greater sensitivity to gonadotropin stimulation with reduced fertilization and ongoing pregnancy rates than their Caucasian counterparts. Eur J Obstet Gynecol Reprod Biol. 2007;134(2):202–7.

    Article  PubMed  CAS  Google Scholar 

  20. Mahmud GLW, Bernal AL, Barlow DH, Yudkin P. A controlled assessment of the in vitro fertilization performance of British women of Indian origin compared with white women. Fertil Steril. 1995;64:103–6.

    PubMed  CAS  Google Scholar 

  21. Lashen H, Afnan M, Sharif K. A controlled comparison of ovarian response to controlled stimulation in first generation Asian women compared with white Caucasians undergoing in vitro fertilisation. Br J Obstet Gynaecol. 1999;106(5):407–9.

    Article  PubMed  CAS  Google Scholar 

  22. Goudas VT, Dumesic DA. Polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1997;26(4):893–912.

    Article  PubMed  CAS  Google Scholar 

  23. Dunaif A. Hyperandrogenic anovulation (PCOS): a unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus. Am J Med. 1995;98(1A):33S–9.

    Article  PubMed  CAS  Google Scholar 

  24. Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism. 1994;43(5):647–54.

    Article  PubMed  CAS  Google Scholar 

  25. Nestler JE, Stovall D, Akhter N, Iuorno MJ, Jakubowicz DJ. Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome. Fertil Steril. 2002;77(2):209–15.

    Article  PubMed  Google Scholar 

  26. Morin-Papunen L, Rantala AS, Unkila-Kallio L, et al. Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial. J Clin Endocrinol Metab. 2012;97(5):1492–500.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Stanford University Hospital, 900 Welch Road, Suite 350, Stanford, CA, 94304, USA

    Stephanie Gustin M.D.

  2. Department of Obstetrics and Gynecology, Harvard Medical School, Massachusetts General Hospital, 25 Shattuck Street, Boston, MA, 02115, USA

    Malinda Lee B.S.

  3. Department of Obstetrics and Gynecology, Stanford University Hospital, 900 Welch Road, Suite 20, Palo Alto, CA, 94304, USA

    Lynn Westphal M.D.

Authors
  1. Stephanie Gustin M.D.
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  2. Malinda Lee B.S.
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  3. Lynn Westphal M.D.
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Corresponding author

Correspondence to Stephanie Gustin M.D. .

Editor information

Editors and Affiliations

  1. , Department of Ob/Gyn, George Washington University, Sunset Hills Road 11150, Reston, 20190, Virginia, USA

    Fady I. Sharara

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Gustin, S., Lee, M., Westphal, L. (2013). Differences in Fertility and Assisted Reproduction in South Asian Women. In: Sharara, F. (eds) Ethnic Differences in Fertility and Assisted Reproduction. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7548-4_8

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  • DOI: https://doi.org/10.1007/978-1-4614-7548-4_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7547-7

  • Online ISBN: 978-1-4614-7548-4

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