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Clinical Implications of the Pathophysiology of Lactic Acidosis: The Role of Defects in Lactate Disposal

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Hypoxia, Metabolic Acidosis, and the Circulation

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

By far the most common reason for clinical lactic acidosis is circulatory insufficiency. The role of ischemia and consequent anaerobic glycolysis in generating large quantities of lactate and accompanying protons is well appreciated. However, the pathophysiological events that lead to diminished rates of lactate disposal in shock are perhaps less well understood, and the bulk of this short review is devoted to this topic. Comment is made on the current controversy concerning the value of bicarbonate therapy in the lactic acidosis of shock, and also on the surprisingly low frequency with which significant lactic acidosis occurs during diabetic ketoacidosis.

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Authors
  1. R. D. Cohen
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Editors and Affiliations

  1. Department of Medicine, School of Medicine and Veterans Affairs Medical Center, University of California, San Francisco, California, USA

    Allen I. Arieff M.D.

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© 1992 American Physiological Society

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Cohen, R.D. (1992). Clinical Implications of the Pathophysiology of Lactic Acidosis: The Role of Defects in Lactate Disposal. In: Arieff, A.I. (eds) Hypoxia, Metabolic Acidosis, and the Circulation. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7542-2_5

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  • DOI: https://doi.org/10.1007/978-1-4614-7542-2_5

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7542-2

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