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Development of Lung Epithelial Ion Transport: Implications for Neonatal Lung Disease

  • Chapter
Lung Development

Part of the book series: Clinical Physiology Series ((CLINPHY))

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Abstract

At birth, the lungs must immediately assume the essential job of gas exchange. There are many associated environmental changes taking place at birth, including an approximate fivefold increase in partial pressure of oxygen (PO2) as air-breathing commences, and tenfold increase in the pulmonary blood flow. For a successful transition to postnatal life, the lungs must also have developed a structural interface between the capillary microcirculation and the epithelium, have a robust antioxidant enzyme defence, and have mature synthetic pathways for surfactant synthesis.

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Authors
  1. Olli Pitkänen
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  2. Hugh O’Brodovich
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Editor information

Editors and Affiliations

  1. Service de Physiologie-Explorations Fonctionnelles, Hôpital Robert Debré, Université Paris 7, Paris, France

    Claude Gaultier

  2. INSERM Unité 319, Université Denis Diderot-Paris 7, Paris, France

    Jacques R. Bourbon

  3. The Medical Research Council Group in Lung Development, Hospital for Sick Children Research Institute, Department of Pediatrics and Physiology, University of Toronto, Toronto, Canada

    Martin Post

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© 1999 American Physiological Society

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Pitkänen, O., O’Brodovich, H. (1999). Development of Lung Epithelial Ion Transport: Implications for Neonatal Lung Disease. In: Gaultier, C., Bourbon, J.R., Post, M. (eds) Lung Development. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7537-8_9

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  • DOI: https://doi.org/10.1007/978-1-4614-7537-8_9

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7537-8

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