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Pulmonary Hypoplasia: Role of Mechanical Factors in Prenatal Lung Growth

  • Chapter
Lung Development

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Pulmonary hypoplasia is a term used to describe lungs that are sufficiently restricted in growth such that their ability to exchange respiratory gases is impaired; however, hypoplastic lungs are usually not simply small but are also structurally abnormal or immature. It is now recognized that fetal lung hypoplasia rarely occurs in isolation and is usually associated with other intrauterine abnormalities. This chapter considers how such abnormalities result in lung hypoplasia, and how lung structure and function are affected. For further information, the reader is directed to reviews of lung hypoplasia and the control of fetal lung growth (34, 42, 48, 62, 78, 90, 96, 139, 149, 163, 168).

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Authors
  1. Richard Harding
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  2. Cheryl Albuquerque
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Editors and Affiliations

  1. Service de Physiologie-Explorations Fonctionnelles, Hôpital Robert Debré, Université Paris 7, Paris, France

    Claude Gaultier

  2. INSERM Unité 319, Université Denis Diderot-Paris 7, Paris, France

    Jacques R. Bourbon

  3. The Medical Research Council Group in Lung Development, Hospital for Sick Children Research Institute, Department of Pediatrics and Physiology, University of Toronto, Toronto, Canada

    Martin Post

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Harding, R., Albuquerque, C. (1999). Pulmonary Hypoplasia: Role of Mechanical Factors in Prenatal Lung Growth. In: Gaultier, C., Bourbon, J.R., Post, M. (eds) Lung Development. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7537-8_14

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