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Atrial Hormones and Other Natriuretic Factors pp 33–38Cite as

Atriopeptin Expression in the Ventricle

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Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

atriopeptins comprise a family of small peptides, originally isolated from rat atria, that exert potent effects on natriuresis, diuresis, and vascular smooth muscle relaxation (3, 5, 17). The active peptides range from 21 to 33 amino acids in length and differ only in the number of residues flanking a 17-amino acid disulfide-linked core. A 126-amino acid prohormone is stored in granules in both atria and is released from heart cells in culture (2). After pharmacological stimulation or atrial stretch, atriopeptin (AP) is found in the circulation primarily as the 28-amino acid peptide, AP28 (10, 24).

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Authors and Affiliations

  1. Department of Biological Sciences, Monsanto Company, Chesterfield, Missouri, USA

    Roger C. Wiegand, Mark L. Day, Charles P. Rodi, David Schwartz & Philip Needleman

  2. Department of Pharmacology, Washington University Medical School, St. Louis, Missouri, USA

    Roger C. Wiegand, Mark L. Day, Charles P. Rodi, David Schwartz & Philip Needleman

Authors
  1. Roger C. Wiegand
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  2. Mark L. Day
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  3. Charles P. Rodi
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  4. David Schwartz
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  5. Philip Needleman
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Editor information

Editors and Affiliations

  1. Department of Medicine, Medical College of Ohio, Toledo, Ohio, USA

    Patrick J. Mulrow

  2. Department of Medicine Health Science Center, University of Colorado, Denver, Colorado, USA

    Robert Schrier

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© 1987 American Physiological Society

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Wiegand, R.C., Day, M.L., Rodi, C.P., Schwartz, D., Needleman, P. (1987). Atriopeptin Expression in the Ventricle. In: Mulrow, P.J., Schrier, R. (eds) Atrial Hormones and Other Natriuretic Factors. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7529-3_4

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  • DOI: https://doi.org/10.1007/978-1-4614-7529-3_4

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7529-3

  • eBook Packages: Springer Book Archive

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