Abstract
Afull history of neurophysiology in the United States has not yet been written, and this chapter seeks only to sketch in a few of its major features, with special attention to the role of experimental techniques and instruments in its maturation as a recognizable subdiscipline. The chapter is divided into two distinct parts, with some names and a few of the themes from the first part recurring in the second part. The first part begins by noting the extent of British influence on the history of American neurophysiology. However, its major aim is to identify the leading social units in the subdiscipline in the United States, including the American Physiological Society (APS), several major university research centers, and the informal network known as the “Axonologists.”
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Notes
For a discussion of the earlier work see E. Clarke and L. S. Jacyna, Nineteenth Century Origins of Neuroscientific Concepts (Los Angeles: Univ. of California Press, 1987), chapt. 4.
V. B. Mountcastle, ed., Medical Physiology, 14th ed. (St. Louis, MO: Mosby, 1980 ), p. 185.
These spectacular experiments on humans were described by H. Cushing, “A Note Upon the Faradic Stimulation of the Postcentral Gyrus in Conscious Patients,” Brain 32 (1909): 4453.
See Cushing, The Pituitary Body and Its Disorders (Philadelphia, PA: Lippincott, 1912).
J. F. Fulton devoted twenty pages in the first two editions of his famous textbook, Physiology of the Nervous System (London: Oxford Univ. Press, 1938, 1943 ) to discussion of the meaning of the angle. A full account of this amusing incident is found in J. C. Eccles and W. C. Gibson, Sherrington, His Life and Thought ( Berlin: Springer International, 1979 ).
H. S. Gasser, Letter to J. Erlanger, 9 October 1923,Washington University School of Medicine Library, St. Louis, MO, by permission.
This description of “Holmes’s straightforward experiment is quoted in J. C. Burnham, Science in America: Historical Selections (New York: Holt, Rinehart, Winston, 1971), p. 191.
The six were H. P. Bowditch (1840–1911),H. H. Donaldson (1857–1938), W. P. Lombard (1885–1939), T. W. Mills (1847–1915), S. W. Mitchell (1829–1914),and Isaac Ott (1847–1916).
Degeneration studies on nerve are summarized by D. M. Barnes, in “Research News: What Makes Nerves Regenerate?” Science 230 (1985): 1024–1025.
An extraordinarily early example was one of those “peculiar” institutions, then named Vassar Female College, which opened in 1861 with a department of physiology as noted in an anonymous editorial in Harper’s Weekly (9 February 1861).
W. B. Cannon, The Way of an Investigator: A Scientist’s Experiences in Medical Research ( New York: Hafner, 1945 ), p. 92.
The reasons for the chairman, Henry Newell Martin, looking favorably on students who wished to pursue physiological problems are discussed by Jane Maienschein in chapter VII in this book.
Donaldson’s postgraduate research was described thus by W. H. Howell, “The American Physiological Society During its First Twenty-Five Years,” In: History of the American Physiological Society Semicentennial 1887–1937 (Baltimore, MD: American Physiological Society, 1938), pp. 1–89,esp. p. 25.
See S. Black, “Pseudopods and Synapses: The Amoeboid Theories of Neuronal Mobility and the Early Foundation of the Synapse Concept, 1894–1900,” Bull. Hist. Med. 55 (1981): 3458.
Gasser, and H. S. Newcomer, “Physiological Action Currents in the Phrenic Nerve: An Application of the Thermionic Vacuum Tube to Nerve Physiology,” Am. J. Physiol. 57 (1921): 1-26.
See K. Lissak and P. Molnar, “Emotional Behavior: The Control of the Emotions and Their Expression,” in The Life and Contributions of Walter Bradford Cannon 1871–1945, ed. C. Mc. Brooks, K. Koizumi, and J. O. Pinkston ( Brooklyn: State Univ. of New York Downstate Medical Center, 1975 ), p. 122.
Lombard’s role at Michigan is described in the recent work of Horace W. Davenport, who points out that among the early members of the American Physiological Society, several more eminent than Lombard spent various periods there, for example, Howell, J. Vaughn, D. W. Bronk, and H. Sewall.
Chapter VII by Maienschein and chapter VIII by Philip Pauly in this book detail the influence of Jacques Loeb on the transition from a disease-oriented discipline to one encompassing dynamic life processes.
R. W. Gerard, “Warren Sturgis McCulloch: Rebel Genius,” Trans. Am. Neurol. Assoc. 95 (1970): 344–345, esp. 344.
I am indebted to E. Clifford Barger for bringing this dedication to my attention.
Quoted from W. O. Fenn, “Alexander Forbes, May 14, 1882—May 27, 1965,” Natl. Acad. Sci. Biogr. Mem. 40 (1969): 113–141, esp. 118–119. The review is A. Forbes, “The Interpretation of Spinal Reflexes in Terms of Present Knowledge of Nerve Conduction,” Physiol. Rev. 2 (1922): 361–414.
From Gerard’s letter to Bronk, 17 March 1930,Rockefeller University Archives, with permission. In additioin to Bronk, copies of the letter were sent to W. R. Amberson, *G. H. Bishop, *H. Davis, *J. Erlanger, *W. O. Fenn, *A. Forbes, *H. S. Gasser, A. B. Wilson, P. Heinbecker, *R. S. Lillie, *G. P. McCouch, *A. M. Monnier, *W. A. H. Rushton, and *F. O. Schmitt. Asterisks indicate those who are known to have attended.
From a letter of Alan C. Burton quoted in Fenn, History of the American Physiological Society: The Third Quarter Century, 1937–1962 (Washington, DC: American Physiological Society, 1963 ), p. 92–93.
As one of the original group, Hallowell Davis wrote a quarter century later, “Only after `The Axonologists’ had dissolved… did the members realize how important it had been in stimulating and shaping the development of neuro-electrophysiology”; Davis, `Joseph Erlanger,“ Natl. Acad. Sci. Biogr. Mem. 41(1970): 110–139, quote on 123.
Fulton, Physiology of the Nervous System ( New York: Oxford Univ. Press, 1938 ).
For a definitive history of the Handbook of Physiology see F. K. O’Malley and Horace W. Magoun, “The First American-Based Handbook of Physiology,” Physiologist 28 (1985): 35–39.
David Nachmansohn wrote that Fulton, in whose laboratory he spent three years, was the first neurophysiologist “to integrate ACh into the metabolic pathways of the nerve cell” in Nachmansohn, Chemical and Molecular Basis of Nerve Activity (New York: Academic, 1959), p. vi.
L. G. Brock, J. S. Coombs, and Eccles. “The Recording of Potentials From Motoneurones With an Intracellular Electrode,” J. Physiol. Lond. 117 (1952): 431–460.
Z. M. Bacq, Chemical Transmission of Nerve Impulses. A Historical Sketch (Oxford, UK: Pergamon, 1975), p. 93.
Forbes and C. Thacher, “Amplification of Action Currents with the Electron Tube in Recording With the String Galvanometer,” Am. J. Physiol. 52 (1920): 409–471.
See Gasser and Newcomer, “Physiological Action Currents.”
Gasser and Erlanger, “The Cathode Ray Oscillograph as a Means of Recording Nerve Action Currents and Induction Shocks,” Am. J. Physiol. 59 (1922): 473–475.
Heinbecker and Bishop, “Differentiation Between Types of Fibers in Certain Components of Involuntary Nervous System,” Proc. Soc. Exp. Biol. Med. 26 (1929): 645–647.
George H. Bishop’s gracious assessment of the incident is quoted in L. H. Marshall, “The Fecundity of Aggregates: The Axonologists at Washington University, 1922–1931,” Perspect. Biol. Med. 26 (1983): 613–636.
E. D. Adrian and B. H. C. Matthews, “The Berger Rhythm: Potential Changes From the Occipital Lobes of Man,” Brain 57 (1934): 355–385.
The early days of the EEG were described from first-hand knowledge in J. L. O’Leary and S. Goldring, Science and Epilepsy: Neuroscience Gains in Epilepsy Research (New York: Raven, 1976), esp. p. 136.
Alfred L. Loomis was a wealthy engineer who occupied himself and his well-equipped laboratory with, in addition to electroencephalography, the same types of biophysical problems as the Eldridge Reeves Johnson Foundation for Medical Physics at the University of Pennsylvania, with which he had contacts.
C. Matteucci, Traité des Phénomenes Electro-physiologiques des Animaux (Paris: Fortin, Masson, 1844 ).
W. R. Ingram et al., “Results of Stimulation of the Tegmentum With the Horsley-Clarke Stereotaxic Apparatus,” Arch. Neurol. Psychiatry 25 (1932): 513–541.
The first report of the instrument was made by Horsley at the meeting of the British Medical Association, in Toronto that year, 1906. The published description was clear and detailed, so much so that replicas or improvements could be made from it, as Ranson and others twenty years later did. The illustrated paper was V. Horsley and R. H. Clarke, “The Structure and Function of the Cerebellum Examined by a New Method,” Brain 31 (1908): 45–124.
Clarke and E. E. Henderson, Atlas of Photographs of the Frontal Sections of the Cranium and Brain of the Rhesus Monkey (Macacus rhesus), special vol., part II ( Baltimore, MD: Johns Hopkins Hospital Reports, 1920 ).
E. Sachs, “On the Structure and Functional Relations of the Optic Thalamus,” Brain 32 (1909): 95–186. Years later Sachs presented this instrument to Magoun, “the new torchbearer.”
Magoun, “The Northwestern Connection with the Reticular Formation,” Surg. Neurol. 24 (1985): 250–252, esp. 250.
Both these innovative contributions were published in Gerard, W. H. Marshall, and L. J. Saul, “Electrical Activity of the Cat’s Brain,” Arch. Neurol. Psychiatry 36 (1936): 675–738. According to Magoun (personal communication), Ranson was not aware that his sections were to be published.
F. H. Pratt, “Excitation of Microscopic Areas: A Non-Polarizable Capillary Electrode,” Am. J. Physiol. 43 (1917): 159–168.
Four years after Pratt’s description of his method (loc. cit.), Ida H. Hyde at the University of Kansas, the first woman to become a member of APS, in 1902, published her work, “A Micro-Electrode and Unicellular Stimulation,” Biol. Bull. 40 (1921): 130–133.
S. Gelfan, “The Electrical Conductivity of Protoplasm and a New Method of its Determination,” Univ. Calif. Publ. Zool. 29 (1927): 453–465. A year later Gelfan was a postdoctoral student of Ralph S. Lillie in the physiology department at the University of Chicago.
Graham Hoyle’s letter correcting some misconceptions about the development of the micro-electrode [Hoyle, “Origins of Intracellular Microelectrodes,” Trends Neurosci. 6 (1983): 163] accorded first place to K. S. Cole’s laboratory with the following publication: B. M. Hogg, C. M. Goss, and Cole, “Potentials in Embryo Rat Heart Muscle Cultures,” Proc. Soc. Exp. Med. Biol. 32 (1934–1935): 304–307.
J. Z. Young, “Structure of Nerve Fibres and Synapses in Some Invertebrates,” Cold Spring Harbor Symp. Quant. Biol. 4 (1936): 1–6.
A. L. Hodgkin and B. Katz, “The Effect of Sodium Ions on the Electrical Activity of the Giant Axon of the Squid,” J. Physiol. Lond. 108 (1949): 37–77.
Cole, and H. J. Curtis, “Electric Impedance of Nerve During Activity,” Nature Lond. 152 (1938): 209.
Cole, “Dynamic Electrical Characteristics of the Squid Axon Membrane,” Arch. Sci. Physiol. 3 (1949): 253–258.
E. Jakobsson and R. Guttman, “Continuous Stimulation and Threshold of Axons: The Other Legacy of Kenneth Cole,” in The Biophysical Approach to Excitable Systems,ed. W. J. Adelman and D. E. Goldman (New York: Plenum, 1981), pp. 197–211, esp. p. 198.
Graham and Gerard, “Membrane Potentials and Excitation of Impaled Single Muscle Fibers,” J. Cell. Comp. Physiol. 28 (1946): 99–117.
G. Ling and Gerard, “The Normal Membrane Potential of Frog Sartorius Fibers,” J. Cell. Comp. Physiol. 34 (1949): 383–396.
B. Renshaw, Forbes, and B. R. Morison, “Activity of Isocortex and Hippocampus: Electrical Studies with Micro-Electrodes,”J. Neurophysiol. 3 (1940): 74–105. An abstract was published in 1938.
Ibid., p. 99.
P. O. Therman, Forbes, and R. Galambos, “Electric Responses Derived From the Superior Cervical Ganglion With Micro-Electrodes,” J Neurophysiol. 3 (1940): 191–200.
Marshall, C. N. Woolsey, and P. Bard, “Cortical Representation of Tactile Sensibility as Indicated by Cortical Potentials,” Science 85 (1937): 388–396.
Woolsey, Marshall, and Bard, “Representation of Cutaneous Tactile Sensibility in Cerebral Cortex of Monkey as Indicated by Evoked Potentials,” Bull. Johns Hopkins Hosp. 70 (1942): 399–441.
Bishop to Fulton, 5 June 1951, Yale Historical Library, New Haven, CT, with permission.
D. H. Hubel and T. N. Weisel, “Receptive Fields of Single Neurones in the Cat’s Striate Cortex,” J. Physiol. Lond. 148 (1959): 574–591.
P. Weiss and H. B. Hisco, “Experiments on the Mechanism of Nerve Growth,” J. Exp. Zool. 107 (1948): 315–395.
Sidney Ochs, has written on the history of nerve repair and regeneration in “A Brief History of Nerve Repair and Regeneration,” In: Nerve Repair and Regeneration: Its Clinical and Experimental Basis, ed. D. L. Jewett and H. R. McCarroll ( St. Louis, MO: Mosby, 1980 ), pp. 1–8.
G. L. Geison, searching for a universally valid conception of scientific change, enumerated the characteristics of an ideal group in “Scientific Change, Emerging Specialties, and Research Schools,” Hist. Sci. 19 (1981): 20–40.
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Marshall, L.H. (1987). Instruments, Techniques, and Social Units in American Neurophysiology, 1870–1950. In: Geison, G.L. (eds) Physiology in the American Context 1850–1940. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7528-6_16
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