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Gene Regulation in Endothelial Cells

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Flow-Dependent Regulation of Vascular Function

Part of the book series: Clinical Physiology Series ((CLINPHY))

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Abstract

The vascular endothelium exists in a mechanically active environment that includes both fluid shear stress generated by flowing blood and stretching forces generated by transmural pressures. The magnitude and direction of these forces vary with time and location in the vasculature. In addition to the wide variety of physical forces to which the endothelium must sustain, changing local velocity profiles can alter the delivery and removal rate of species to and from the endothelial surface by fluid convection. The continual presence of physical forces generated by steady or time-dependent flows can regulate endothelial cell gene expression with likely subsequent effects on vessel wall biology. This chapter explores physiological and pathological instances where regulation of endothelial gene expression and protein secretion by hemodynamic forces may control vessel function. Recent work by several laboratories has shown that endothelial cell protein secretion is altered by hemodynamic forces and that these changes likely occur at the genetic level. A summary of research investigating endothelial cell gene expression in the presence of fluid shear stress is shown in Table 4.1.

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Authors
  1. Scott L. Diamond
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  2. Larry V. Mcintire
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA

    John A. Bevan M.D.

  2. Department of Physiology, New York Medical College, Valhalla, New York, USA

    Gabor Kaley Ph.D.

  3. Berlex Biosciences, Richmond, California, USA

    Gabor M. Rubanyi M.D., Ph.D.

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© 1995 American Physiological Society

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Diamond, S.L., Mcintire, L.V. (1995). Gene Regulation in Endothelial Cells. In: Bevan, J.A., Kaley, G., Rubanyi, G.M. (eds) Flow-Dependent Regulation of Vascular Function. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7527-9_4

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  • DOI: https://doi.org/10.1007/978-1-4614-7527-9_4

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7527-9

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