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Atherosclerosis and the Role of Wall Shear Stress

  • Chapter
Flow-Dependent Regulation of Vascular Function

Part of the book series: Clinical Physiology Series ((CLINPHY))

Abstract

Atherosclerosis is the chief cause of death in the United States and in much of the western world. It is a disease of the large- and medium-size arteries. It also is a disease which involves complex interactions between a wide variety of factors (41, 88–90, 101, 114–115). Included in this are: (1) the endogenous cells of the arterial wall, that is, endothelial and smooth muscle cells; (2) formed elements of blood, notably monocytes and platelets; (3) plasma proteins, including low density lipoproteins (LDL); (4) connective tissue elements of the arterial intima; (5) environmental and genetic factors; and (6) hemodynamic-related factors. In this chapter we will be exploring the last of these—the role of blood flow and in particular wall shear stress, the frictional force imposed by flowing blood.

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Authors
  1. Robert M. Nerem
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Editors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of Vermont, Burlington, Vermont, USA

    John A. Bevan M.D.

  2. Department of Physiology, New York Medical College, Valhalla, New York, USA

    Gabor Kaley Ph.D.

  3. Berlex Biosciences, Richmond, California, USA

    Gabor M. Rubanyi M.D., Ph.D.

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© 1995 American Physiological Society

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Nerem, R.M. (1995). Atherosclerosis and the Role of Wall Shear Stress. In: Bevan, J.A., Kaley, G., Rubanyi, G.M. (eds) Flow-Dependent Regulation of Vascular Function. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7527-9_14

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  • DOI: https://doi.org/10.1007/978-1-4614-7527-9_14

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