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Renin-Aldosterone System

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Book cover High Altitude and Man

Part of the book series: Clinical Physiology ((CLINPHY))

Abstract

the effect of altitude and hypoxia on the renin-angiotensin-aldosterone system is interesting for many reasons. As a physician and mountaineer I have been puzzled for many years by the etiology of acute mountain sickness, especially high-altitude pulmonary edema (HAPE). A derangement of fluid homeostasis produced indirectly by hypoxia appeared to be one characteristic. The time lag of 6–24 h between exposure to hypoxia and the onset of symptoms suggests that hypoxia may stimulate a hormonal response which over this time course could upset fluid homeostasis enough to cause symptoms. For a time we considered the antidiuretic hormone, but, although levels are raised in cases of HAPE (4), this is more likely a result than a cause of the condition. Case reports of HAPE persistently stress the importance of strenuous exertion in the formation of this condition. We therefore decided to first study the effect of exercise typical of mountaineers on fluid balance.

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Author information

Authors and Affiliations

  1. Medical Research Council Clinical Research Centre, Northwick Park Hospital, Harrow, England

    James S. Milledge

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  1. James S. Milledge
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Editors and Affiliations

  1. Section of Physiology, Department of Medicine, University of California, San Diego, La Jolla, California, USA

    John B. West

  2. Department of Physiology, Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Sukhamay Lahiri

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© 1984 American Physiological Society

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Milledge, J.S. (1984). Renin-Aldosterone System. In: West, J.B., Lahiri, S. (eds) High Altitude and Man. Clinical Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7525-5_6

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  • DOI: https://doi.org/10.1007/978-1-4614-7525-5_6

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7525-5

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